ID   CREC_ASPFN              Reviewed;         572 AA.
AC   B8N4F5;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Probable catabolite repression protein creC;
GN   Name=creC; ORFNames=AFLA_036580;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
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DR   EMBL; EQ963473; EED56386.1; -; Genomic_DNA.
DR   RefSeq; XP_002375168.1; XM_002375127.1.
DR   AlphaFoldDB; B8N4F5; -.
DR   SMR; B8N4F5; -.
DR   STRING; 5059.CADAFLAP00003033; -.
DR   EnsemblFungi; EED56386; EED56386; AFLA_036580.
DR   VEuPathDB; FungiDB:AFLA_036580; -.
DR   eggNOG; KOG2394; Eukaryota.
DR   HOGENOM; CLU_016971_1_1_1; -.
DR   OMA; LHRPKAA; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN           1..572
FT                   /note="Probable catabolite repression protein creC"
FT                   /id="PRO_0000395688"
FT   REPEAT          226..266
FT                   /note="WD 1"
FT   REPEAT          306..347
FT                   /note="WD 2"
FT   REPEAT          348..387
FT                   /note="WD 3"
FT   REPEAT          390..434
FT                   /note="WD 4"
FT   REPEAT          506..543
FT                   /note="WD 5"
FT   REGION          36..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          541..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..59
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..562
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   572 AA;  63235 MW;  F13E38A0C43B474E CRC64;
     MAQGPSCASE LHYYRALDHA NAGFATGTYH LKDDLHLATP PPHPSEAPVV NPNPLATVPT
     PPTSGVKLSL VSVGQRNKLP VFTSKEKVTA PPFADGNPAL AAIPTKDGLK RRKPKNNIIK
     SSSSFVSRVI THEASSKRLN DRNPDGLFAF ANINRAFQWL DLSSKNKEEP LAKILFTKAH
     MLTHDINELT KSSSHIDIAM GSSAGDIIWY EPISQKYARI NKNGVVSNSP VTHIKWIPGS
     ENMFMAAHAN GQLVVYDKEK EDALFTPEIS NHSAEAMKAS SRLPLQVLKS VNSRNQKTNP
     VALWKLANQK ISQFAFSPDQ RHLAVVLEDG SLRVMDYLKE EVLDIFRSYY GGLICVCWSP
     DGKYIVTGGQ DDLVTIWSFP ERKIVARCQG HNSWVSTVAF DPWRCDERTY RFGSVGDDCR
     LLLWDFSVGM LHRPRAHQAS ARQRTSMIAS NTQHFNRHRA DSASNRMRSD SQRTADTYND
     YDSAVRHPVE PRARTALLPP IMSKIVGDDP ICWLGFQEDS IMTSSLEGHI RTWDRPREGI
     NDSYNGNTSS PAISTSAAGS GSGIADSAMG SL