ID   CREC_ASPFU              Reviewed;         566 AA.
AC   Q4WN25;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Probable catabolite repression protein creC;
GN   Name=creC; ORFNames=AFUA_6G07860;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL88639.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAHF01000006; EAL88639.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_750677.1; XM_745584.1.
DR   AlphaFoldDB; Q4WN25; -.
DR   SMR; Q4WN25; -.
DR   STRING; 746128.CADAFUBP00007191; -.
DR   GeneID; 3508807; -.
DR   KEGG; afm:AFUA_6G07860; -.
DR   eggNOG; KOG2394; Eukaryota.
DR   HOGENOM; CLU_016971_1_1_1; -.
DR   InParanoid; Q4WN25; -.
DR   OrthoDB; 907634at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..566
FT                   /note="Probable catabolite repression protein creC"
FT                   /id="PRO_0000395689"
FT   REPEAT          225..265
FT                   /note="WD 1"
FT   REPEAT          305..340
FT                   /note="WD 2"
FT   REPEAT          341..379
FT                   /note="WD 3"
FT   REPEAT          382..426
FT                   /note="WD 4"
FT   REPEAT          498..535
FT                   /note="WD 5"
FT   REGION          433..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..566
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   566 AA;  62293 MW;  271EE5CF15D84780 CRC64;
     MAVPVVETNN ILSHPEGGCP LQVGEGTYEL KDDLHLATPP PHPSEAPIIN PNPLATVPTP
     PTSGVKVSLV CVSPRSRTPS FISKQIVTAP PFGDGNPALV PAPVKDGLKR RKPKNNIIKS
     SSSFVSRVIT HEVATKRLSE RSPEGLFAFA NINRAFQWLD LSSKQKEDPL AKILFTKAHM
     LCHDINEVTK SPSHIDVVMG SSAGDIIWYE PISQKYARIN KNGVVCNSPV THIKWIPGSE
     NLFMASHANG QLVVYDKEKE DALFTPEIQD QSAEAVKASS TQPLQVLKSV NSRNQKTNPV
     ALWKLANQRI SHFAFSPDQR HLAVVLEDGS LRVMDYLKED YYGGLICVCW SPDGKYIVTG
     GQDDLVTIWS FPERKIVARC QGHNSWVSAV AFDPWQCDER TYRFGSVGDD CRLLLWDFSV
     GMLHRPKVHQ TSARQRTSMV AGSSQYGNRH RADSVGNRMR SDSQRTANTY ESCDQAVRHP
     VEPRARTALL PPIMSKVVGT DPICWLGFQE DCIMTSSLEG HIRTWDRPRE GINDKYNDQS
     SSTAVSASAA GSGSISGLAE STMGSL