ID   CREC_ASPNC              Reviewed;         591 AA.
AC   A2QVV2;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Probable catabolite repression protein creC;
GN   Name=creC; ORFNames=An11g02750;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
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DR   EMBL; AM270227; CAK96904.1; -; Genomic_DNA.
DR   RefSeq; XP_001394276.1; XM_001394239.2.
DR   AlphaFoldDB; A2QVV2; -.
DR   SMR; A2QVV2; -.
DR   PaxDb; A2QVV2; -.
DR   EnsemblFungi; CAK96904; CAK96904; An11g02750.
DR   GeneID; 4984505; -.
DR   KEGG; ang:ANI_1_388094; -.
DR   VEuPathDB; FungiDB:An11g02750; -.
DR   HOGENOM; CLU_016971_1_1_1; -.
DR   Proteomes; UP000006706; Chromosome 7R.
DR   GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..591
FT                   /note="Probable catabolite repression protein creC"
FT                   /id="PRO_0000395690"
FT   REPEAT          249..289
FT                   /note="WD 1"
FT   REPEAT          330..371
FT                   /note="WD 2"
FT   REPEAT          372..411
FT                   /note="WD 3"
FT   REPEAT          414..458
FT                   /note="WD 4"
FT   REPEAT          530..567
FT                   /note="WD 5"
FT   REGION          477..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..505
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   591 AA;  64927 MW;  DF0554098FDC54C5 CRC64;
     MFVLPPPPPR YTVPVAYAAG ASNGMAVPVV ETNNIISHPE GGCSLQAGEG TYLLRDDLHL
     ATPPPHPSEA PVMNPNPLAT VPAPPTSGVK LSLVSIGSRI KTPTPSVDGV GAASLFGDGN
     PALAAPPVKE GLKRRKPKNN IIKSSSSFVS RVITHETATK RLNDRNPDGL FAFANINRAF
     QWLDLSAKQK EEPVTKILFT KAHMISHDIN ELTKSTSHID VVMGSSAGDI IWYEPMSQKY
     ARINKNGVVN NSPVTHIKWI PGSENLFMAA HANGQLVVYD KEKEDALFAP ELGSPSAETM
     KSSSGRSPLQ ILKSVNSRNQ KTNPVALWKL ANQKITQFAF SPDRRHLAVV LEDGSLRVMD
     YLKEEVLDIF RSYYGGLICV CWSPDGKYIV TGGQDDLVTI WSLPERKIVA RCQGHNSWVS
     AVAFDPWRCD DRTYRFGSVG DDCRLLLWDF SVGMLHRPRV HQANARQRTS MIVSNTQHLN
     RHRADSGGNR TRSDSQETAD TYNSYDPTVR HPVEPRARTA LLPPIMSKIV GEDPICWLGF
     QEDSIMTSSL EGHIRTWDRP REGINDNYSY SPAISASATG SGRADSMMGS L