CREC_ASPOR
ID CREC_ASPOR Reviewed; 572 AA.
AC Q2UM42;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Probable catabolite repression protein creC;
GN Name=creC; ORFNames=AO090003000149;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Component of the regulatory network controlling carbon source
CC utilization through ubiquitination and deubiquitination involving creA,
CC creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC CreB deubiquitinating enzyme in the absence of carbon catabolite
CC repression. CreB deubiquitinating enzyme stabilized in a complex with
CC the CreC leads to the expression of genes such as those in the proline
CC and quinate pathways (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
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DR EMBL; AP007155; BAE57373.1; -; Genomic_DNA.
DR RefSeq; XP_001819375.2; XM_001819323.2.
DR AlphaFoldDB; Q2UM42; -.
DR SMR; Q2UM42; -.
DR STRING; 510516.Q2UM42; -.
DR EnsemblFungi; BAE57373; BAE57373; AO090003000149.
DR GeneID; 5991358; -.
DR KEGG; aor:AO090003000149; -.
DR VEuPathDB; FungiDB:AO090003000149; -.
DR HOGENOM; CLU_016971_1_1_1; -.
DR OMA; LHRPKAA; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..572
FT /note="Probable catabolite repression protein creC"
FT /id="PRO_0000395691"
FT REPEAT 226..266
FT /note="WD 1"
FT REPEAT 306..347
FT /note="WD 2"
FT REPEAT 348..387
FT /note="WD 3"
FT REPEAT 390..434
FT /note="WD 4"
FT REPEAT 506..543
FT /note="WD 5"
FT REGION 36..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..59
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 63235 MW; F13E38A0C43B474E CRC64;
MAQGPSCASE LHYYRALDHA NAGFATGTYH LKDDLHLATP PPHPSEAPVV NPNPLATVPT
PPTSGVKLSL VSVGQRNKLP VFTSKEKVTA PPFADGNPAL AAIPTKDGLK RRKPKNNIIK
SSSSFVSRVI THEASSKRLN DRNPDGLFAF ANINRAFQWL DLSSKNKEEP LAKILFTKAH
MLTHDINELT KSSSHIDIAM GSSAGDIIWY EPISQKYARI NKNGVVSNSP VTHIKWIPGS
ENMFMAAHAN GQLVVYDKEK EDALFTPEIS NHSAEAMKAS SRLPLQVLKS VNSRNQKTNP
VALWKLANQK ISQFAFSPDQ RHLAVVLEDG SLRVMDYLKE EVLDIFRSYY GGLICVCWSP
DGKYIVTGGQ DDLVTIWSFP ERKIVARCQG HNSWVSTVAF DPWRCDERTY RFGSVGDDCR
LLLWDFSVGM LHRPRAHQAS ARQRTSMIAS NTQHFNRHRA DSASNRMRSD SQRTADTYND
YDSAVRHPVE PRARTALLPP IMSKIVGDDP ICWLGFQEDS IMTSSLEGHI RTWDRPREGI
NDSYNGNTSS PAISTSAAGS GSGIADSAMG SL