ID   CREC_ASPTN              Reviewed;         588 AA.
AC   Q0CKB1;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable catabolite repression protein creC;
GN   Name=creC; ORFNames=ATEG_05873;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
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DR   EMBL; CH476601; EAU33634.1; -; Genomic_DNA.
DR   RefSeq; XP_001215051.1; XM_001215051.1.
DR   AlphaFoldDB; Q0CKB1; -.
DR   SMR; Q0CKB1; -.
DR   STRING; 341663.Q0CKB1; -.
DR   EnsemblFungi; EAU33634; EAU33634; ATEG_05873.
DR   GeneID; 4321379; -.
DR   VEuPathDB; FungiDB:ATEG_05873; -.
DR   eggNOG; KOG2394; Eukaryota.
DR   HOGENOM; CLU_016971_1_1_1; -.
DR   OMA; LHRPKAA; -.
DR   OrthoDB; 907634at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..588
FT                   /note="Probable catabolite repression protein creC"
FT                   /id="PRO_0000395692"
FT   REPEAT          249..289
FT                   /note="WD 1"
FT   REPEAT          323..364
FT                   /note="WD 2"
FT   REPEAT          365..404
FT                   /note="WD 3"
FT   REPEAT          407..451
FT                   /note="WD 4"
FT   REPEAT          523..560
FT                   /note="WD 5"
FT   REGION          452..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          569..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..475
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..499
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   588 AA;  64593 MW;  94118976CCF64CF1 CRC64;
     MFVLPPPPPR YTIPVAYAAG ASNGMAVPVV ETNNVITKPE GGCPLQVGEG TYHLQDDLHL
     ATPPPHPSEA PIINPNPLAT VPTPPTSGVK LSLVNIGPRN KNPVFAMKES VLAPPFGDGN
     PALAAPAVKD GLKRRKPKNN IIKSSSSFVS RVITHEASTK RLNDRNPEGL FAFANINRAF
     QWLDLGSKQK EEPLAKILFT KAHMLSHDIN ELTKSASHID VVMGSSAGDI IWYEPISQKY
     ARINKNGVVC NSPVTHIKWV PGSENLFMAA HANGQLVVYD KEKEDALFTP EEPVKSSGQQ
     PLQVLKSVNS RNQKTNPVAL WKLANQKITQ FAFSPDQRHL AVVLEDGSLR VMDYLEEEVL
     DIFRSYYGGL ICVCWSPDGK YIVTGGQDDL VTIWSFPERK IVARCQGHNS WVSTVAFDPW
     RCDERTYRFG SVGDDCRLLL WDFSVGMLHR PRAHQASTRQ RTSMITSNSQ HASRHRADSA
     GNRARSDSQR TADGYDEYDQ AVRHPVEPRA RTALLPPIMS KEIGSDPICW LGFQEDSIMT
     SSLEGHIRTW DRPREGINDT YNAHASSSAI SAGAGSGSAV ANSARGSL