ID   CREC_EMENI              Reviewed;         592 AA.
AC   Q9P4R5; C8V4P7; Q5B5L4;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Catabolite repression protein creC;
GN   Name=creC; ORFNames=AN4166;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=10852476; DOI=10.1007/s004380051202;
RA   Todd R.B., Lockington R.A., Kelly J.M.;
RT   "The Aspergillus nidulans creC gene involved in carbon catabolite
RT   repression encodes a WD40 repeat protein.";
RL   Mol. Gen. Genet. 263:561-570(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=11442830; DOI=10.1046/j.1365-2958.2001.02474.x;
RA   Lockington R.A., Kelly J.M.;
RT   "Carbon catabolite repression in Aspergillus nidulans involves
RT   deubiquitination.";
RL   Mol. Microbiol. 40:1311-1321(2001).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH CREB.
RX   PubMed=11918805; DOI=10.1046/j.1365-2958.2002.02811.x;
RA   Lockington R.A., Kelly J.M.;
RT   "The WD40-repeat protein CreC interacts with and stabilizes the
RT   deubiquitinating enzyme CreB in vivo in Aspergillus nidulans.";
RL   Mol. Microbiol. 43:1173-1182(2002).
RN   [6]
RP   FUNCTION.
RX   PubMed=12750323; DOI=10.1093/genetics/164.1.95;
RA   Boase N.A., Lockington R.A., Adams J.R., Rodbourn L., Kelly J.M.;
RT   "Molecular characterization and analysis of the acrB gene of Aspergillus
RT   nidulans: a gene identified by genetic interaction as a component of the
RT   regulatory network that includes the CreB deubiquitination enzyme.";
RL   Genetics 164:95-104(2003).
RN   [7]
RP   FUNCTION.
RX   PubMed=18512059; DOI=10.1007/s00294-008-0198-6;
RA   Katz M.E., Bernardo S.M., Cheetham B.F.;
RT   "The interaction of induction, repression and starvation in the regulation
RT   of extracellular proteases in Aspergillus nidulans: evidence for a role for
RT   CreA in the response to carbon starvation.";
RL   Curr. Genet. 54:47-55(2008).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways. {ECO:0000269|PubMed:10852476,
CC       ECO:0000269|PubMed:11442830, ECO:0000269|PubMed:11918805,
CC       ECO:0000269|PubMed:12750323, ECO:0000269|PubMed:18512059}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000269|PubMed:11918805}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF63188.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAA59427.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF136452; AAF63188.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AACD01000067; EAA59427.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001302; CBF74571.1; -; Genomic_DNA.
DR   RefSeq; XP_661770.1; XM_656678.1.
DR   AlphaFoldDB; Q9P4R5; -.
DR   SMR; Q9P4R5; -.
DR   STRING; 162425.CADANIAP00004506; -.
DR   EnsemblFungi; CBF74571; CBF74571; ANIA_04166.
DR   EnsemblFungi; EAA59427; EAA59427; AN4166.2.
DR   GeneID; 2873591; -.
DR   KEGG; ani:AN4166.2; -.
DR   VEuPathDB; FungiDB:AN4166; -.
DR   eggNOG; KOG2394; Eukaryota.
DR   HOGENOM; CLU_016971_1_1_1; -.
DR   InParanoid; Q9P4R5; -.
DR   OMA; LHRPKAA; -.
DR   OrthoDB; 907634at2759; -.
DR   Proteomes; UP000000560; Chromosome II.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0045013; P:carbon catabolite repression of transcription; IMP:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..592
FT                   /note="Catabolite repression protein creC"
FT                   /id="PRO_0000050943"
FT   REPEAT          248..288
FT                   /note="WD 1"
FT   REPEAT          327..368
FT                   /note="WD 2"
FT   REPEAT          369..408
FT                   /note="WD 3"
FT   REPEAT          411..455
FT                   /note="WD 4"
FT   REPEAT          529..566
FT                   /note="WD 5"
FT   REGION          119..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          556..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  65511 MW;  F94C7B5C1ADCC6E9 CRC64;
     MFVLPPPPPR YTVPVAYAAG ASNGMAVPIV ETNNIITHPE KGCPLQVGEG TYQLQDDLHL
     ATPPPHPSEA PIINPNPLAT VPNPPTSGVK LSLISLGLRN KTAFPSKVQV TARPFGDGNS
     ALAAAPVKDP SKKRKPKNNI IKSSSSFVSR VIIHEATTKR LNDRDPEGLF AFANINRAFQ
     WLDLSSKHKD EPLSKILFTK AHMISHDVNE ITKSSAHIDV IMGSSAGDIF WYEPISQKYA
     RINKNGIINS SPVTHIKWIP GSENFFIAAH ENGQLVVYDK EKEDALFIPE LPEQSAESVK
     PSRWSLQVLK SVNSKNQKAN PVAVWRLANQ KITQFAFSPD HRHLAVVLED GTLRLMDYLQ
     EEVLDVFRSY YGGFTCVCWS PDGKYIVTGG QDDLVTIWSL PERKIIARCQ GHDSWVSAVA
     FDPWRCDERT YRIGSVGDDC NLLLWDFSVG MLHRPKVHHQ TSARHRTSLI APSSQQPNRH
     RADSSGNRMR SDSQRTAADS ESAPDQPVQH PVESRARTAL LPPIMSKAVG EDPICWLGFQ
     EDTIMTSSLE GHIRTWDRPR ENISDNYGDQ KSSETLGTGK EAGHPASSMG SL