ID   CREC_NEOFI              Reviewed;         603 AA.
AC   A1DMI8;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Probable catabolite repression protein creC;
GN   Name=creC; ORFNames=NFIA_053550;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW16009.1; -; Genomic_DNA.
DR   RefSeq; XP_001257906.1; XM_001257905.1.
DR   AlphaFoldDB; A1DMI8; -.
DR   SMR; A1DMI8; -.
DR   STRING; 36630.CADNFIAP00004258; -.
DR   EnsemblFungi; EAW16009; EAW16009; NFIA_053550.
DR   GeneID; 4584421; -.
DR   KEGG; nfi:NFIA_053550; -.
DR   VEuPathDB; FungiDB:NFIA_053550; -.
DR   eggNOG; KOG2394; Eukaryota.
DR   HOGENOM; CLU_016971_1_1_1; -.
DR   OMA; LHRPKAA; -.
DR   OrthoDB; 907634at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..603
FT                   /note="Probable catabolite repression protein creC"
FT                   /id="PRO_0000395693"
FT   REPEAT          255..295
FT                   /note="WD 1"
FT   REPEAT          335..376
FT                   /note="WD 2"
FT   REPEAT          377..416
FT                   /note="WD 3"
FT   REPEAT          419..463
FT                   /note="WD 4"
FT   REPEAT          535..572
FT                   /note="WD 5"
FT   REGION          470..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..510
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..603
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   603 AA;  66128 MW;  A241F6A304D15890 CRC64;
     MVAISLSFVL PPPPPRYTVP VAYAAGAANG MAVPVVETNN ILSHPEGGCP LQVGEGTYEL
     KDDLHLATPP PHPSEAPIIN PNPLATVPTP PTSGVKVSLV CVSPRSKTPS FISKQIVTAP
     PFGDGNPALV PAPVKDGLKR RKPKNNIIKS SSSFVSRVIT HEAATKRLSE RSPEGLFAFA
     NINRAFQWLD LSSKQKEEPL AKILFTKAHM LCHDINEVTK SPSHIDMVMG SSAGDIIWYE
     PISQKYARIN KNGVVSNSPV THIKWIPGSE NLFMASHANG QLVVYDKEKE DALFTPEIQD
     QSAEALKASS RQPLQVLKSV NSRNQKTNPV ALWKLANQRI SHFAFSPDQR HLAVVLEDGS
     LRVMDYLKEE VLDIFRSYYG GLICVCWSPD GKYIVTGGQD DLLTIWSFPE RKIVARCQGH
     NSWVSAVAFD PWQCDERTYR FGSVGDDCRL LLWDFSVGML HRPKVHQASA RQRTSMVAGS
     SQYGNRHRAD SAGNRMRSDS QRTANTYESC DQAVRHPVEP RARTALLPPI MSKVVGTDPI
     CWLGFQEDCI MTSSLEGHIR TWDRPREGIN DKYNDQSSSP AVSASAAGSG SVSGLAESTM
     GSL