CRED_ASPFC
ID CRED_ASPFC Reviewed; 601 AA.
AC B0Y7I1;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Probable HECT-type ubiquitin ligase-interacting protein creD;
DE AltName: Full=Carbon catabolite repressor D;
GN Name=creD; ORFNames=AFUB_073890;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the regulatory network controlling carbon source
CC utilization through ubiquitination and deubiquitination involving creA,
CC creB, creC, creD and acrB. May be involved in signaling by recognizing
CC appropriately phosphorylated substrates via its arrestin domains and
CC then recruit a HECT-type ubiquitin ligase such as hulA, leading to
CC ubiquitination of the substrate, providing a link between
CC ubiquitination and phosphorylation in protein regulation and stability
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hulA. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDP49362.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS499599; EDP49362.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; B0Y7I1; -.
DR SMR; B0Y7I1; -.
DR VEuPathDB; FungiDB:AFUB_073890; -.
DR PhylomeDB; B0Y7I1; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0031396; P:regulation of protein ubiquitination; ISS:UniProtKB.
DR Gene3D; 2.60.40.640; -; 1.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Ubl conjugation pathway.
FT CHAIN 1..601
FT /note="Probable HECT-type ubiquitin ligase-interacting
FT protein creD"
FT /id="PRO_0000395696"
FT REGION 374..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 66388 MW; 75694E26A6B84798 CRC64;
MALSFFGGGG ASHLKYFDIR LDEDYIVFRG GEQEAASAQL SGKLLLCLSE PLSVKHVRLN
LTGISRVCWH LPSSSATGGR KSWREKVFYE KSWTFRDAGK SKTEILAAGN YEFPFHVILE
GSMPESVEGL SDTYVTYRFK AEIGRKYAKD IVVRKPLRII RTLDSSALEL SHAMSVENIW
PNKIEYSIST PTKAVIFGTS IRVDFKLIPL LKGLKIGQIV SQLIESHDLT LNPEDPDSVR
NTYKNTRTIV NDEHELDEEG NLEIIDEAAE GYQFSRFLDL PKTLTRCLQD TDTRGIKIRH
KLKFRVQLLN PDGHISELRA TLPVSIFISP NLAIDDNNNL VDQTPQSAQR AVNDLAQQAP
PLYGEHQFDQ LYSEVDPSGY RTPGPGSGPG TPFGTLSRNL SAENLASMNA LTNTDISASA
LHSRLSNLHA SRFSNPSPSD ADGHTDAEYR RLGVSTDSFG PSSGSNSQSP ASPELSRRPS
DEGYHDHDYI PSGMATPFHP QFAEVESLSR VPSYSTAVRS SVGPCDSELP DYQAVVAEDT
AMPTLQSPQQ AHIRSVGRGV STGHTGIDVH HLRSGFFNSR TSAHHDDDDR RLRLVQARAR
V