CRED_ECOLI
ID CRED_ECOLI Reviewed; 450 AA.
AC P08369; Q2M5R7;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Inner membrane protein CreD;
GN Name=creD; Synonyms=cet; OrderedLocusNames=b4400, JW4363;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2835585; DOI=10.1111/j.1365-2958.1988.tb00012.x;
RA Drury L.S., Buxton R.S.;
RT "Identification and sequencing of the Escherichia coli cet gene which codes
RT for an inner membrane protein, mutation of which causes tolerance to
RT colicin E2.";
RL Mol. Microbiol. 2:109-119(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3531171; DOI=10.1128/jb.168.1.294-302.1986;
RA Amemura M., Makino K., Shinagawa H., Nakata A.;
RT "Nucleotide sequence of the phoM region of Escherichia coli: four open
RT reading frames may constitute an operon.";
RL J. Bacteriol. 168:294-302(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 254-450.
RX PubMed=2984198; DOI=10.1016/s0021-9258(18)89255-9;
RA Drury L.S., Buxton R.S.;
RT "DNA sequence analysis of the dye gene of Escherichia coli reveals amino
RT acid homology between the dye and OmpR proteins.";
RL J. Biol. Chem. 260:4236-4242(1985).
RN [7]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Mutations of this gene leads to an enhanced
CC transcription of the gene cause tolerance to colicin E2.
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DR EMBL; M13608; AAA24376.1; -; Genomic_DNA.
DR EMBL; Y00538; CAA68602.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97296.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77353.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78389.1; -; Genomic_DNA.
DR PIR; D25038; BVECCT.
DR RefSeq; NP_418817.1; NC_000913.3.
DR RefSeq; WP_000920294.1; NZ_LN832404.1.
DR AlphaFoldDB; P08369; -.
DR BioGRID; 4262782; 8.
DR STRING; 511145.b4400; -.
DR PaxDb; P08369; -.
DR PRIDE; P08369; -.
DR EnsemblBacteria; AAC77353; AAC77353; b4400.
DR EnsemblBacteria; BAE78389; BAE78389; BAE78389.
DR GeneID; 948868; -.
DR KEGG; ecj:JW4363; -.
DR KEGG; eco:b4400; -.
DR PATRIC; fig|1411691.4.peg.2284; -.
DR EchoBASE; EB0143; -.
DR eggNOG; COG4452; Bacteria.
DR HOGENOM; CLU_036281_1_0_6; -.
DR InParanoid; P08369; -.
DR OMA; RVHPIQY; -.
DR PhylomeDB; P08369; -.
DR BioCyc; EcoCyc:EG10145-MON; -.
DR PRO; PR:P08369; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR010364; Uncharacterised_IM_CreD.
DR PANTHER; PTHR30092; PTHR30092; 1.
DR Pfam; PF06123; CreD; 1.
DR PIRSF; PIRSF004548; CreD; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..450
FT /note="Inner membrane protein CreD"
FT /id="PRO_0000079345"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..297
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..347
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..378
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..450
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 49830 MW; B2D9F63197EB1B13 CRC64;
MLKSPLFWKM TSLFGAVLLL LIPIMLIRQV IVERADYRSD VEDAIRQSTS GPQKLVGPLI
AIPVTELYTV QEEDKTVERK RSFIHFWLPE SLMVDGNQNV EERKIGIYTG QVWHSDLTLK
ADFDVSRLSE LNAPNITLGK PFIVISVGDA RGIGVVKAPE VNGTALTIEP GTGLEQGGQG
VHIPLPEGDW RKQNLKLNMA LNLSGTGDLS VVPGGRNSEM TLTSNWPHPS FLGDFLPAKR
EVSESGFQAH WQSSWFANNL GERFASGNDT GWENFPAFSV AVTTPADQYQ LTDRATKYAI
LLIALTFMAF FVFETLTAQR LHPMQYLLVG LSLVMFYLLL LALSEHTGFT VAWIIASLIG
AIMNGIYLQA VLKGWCNSML FTLALLLLDG VMWGLLNSAD SALLLGTSVL VVALAGMMFV
TRNIDWYAFS LPKMKASKEV TTDDELRIWK
