CREG1_MOUSE
ID CREG1_MOUSE Reviewed; 220 AA.
AC O88668; Q3UNP8; Q8C3I1;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein CREG1;
DE AltName: Full=Cellular repressor of E1A-stimulated genes 1;
DE Flags: Precursor;
GN Name=Creg1; Synonyms=Creg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9710587; DOI=10.1128/mcb.18.9.5032;
RA Veal E., Eisenstein M., Tseng Z.H., Gill G.;
RT "A cellular repressor of E1A-stimulated genes that inhibits activation by
RT E2F.";
RL Mol. Cell. Biol. 18:5032-5041(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart, Kidney, Liver, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, INDUCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=10815803; DOI=10.1038/sj.onc.1203529;
RA Veal E., Groisman R., Eisenstein M., Gill G.;
RT "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human
RT embryonal carcinoma cells.";
RL Oncogene 19:2120-2128(2000).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May contribute to the transcriptional control of cell growth
CC and differentiation. Antagonizes transcriptional activation and
CC cellular transformation by the adenovirus E1A protein. The
CC transcriptional control activity of cell growth requires interaction
CC with IGF2R (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with IGF2R; the interaction is dependent
CC on glycosylation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10815803}.
CC -!- DEVELOPMENTAL STAGE: Found at low level from 7 dpc and increased during
CC embryonic development. {ECO:0000269|PubMed:10815803}.
CC -!- INDUCTION: Induced during differentiation.
CC {ECO:0000269|PubMed:10815803}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CREG family. {ECO:0000305}.
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DR EMBL; AF084524; AAC34862.1; -; mRNA.
DR EMBL; AK005388; BAB23994.1; -; mRNA.
DR EMBL; AK010947; BAB27285.1; -; mRNA.
DR EMBL; AK085844; BAC39549.1; -; mRNA.
DR EMBL; AK144101; BAE25699.1; -; mRNA.
DR EMBL; BC027426; AAH27426.1; -; mRNA.
DR CCDS; CCDS35759.1; -.
DR RefSeq; NP_035934.1; NM_011804.2.
DR RefSeq; XP_006496993.1; XM_006496930.1.
DR AlphaFoldDB; O88668; -.
DR SMR; O88668; -.
DR BioGRID; 241197; 3.
DR STRING; 10090.ENSMUSP00000107060; -.
DR GlyConnect; 2620; 5 N-Linked glycans (1 site).
DR GlyGen; O88668; 2 sites, 5 N-linked glycans (1 site).
DR iPTMnet; O88668; -.
DR PhosphoSitePlus; O88668; -.
DR EPD; O88668; -.
DR jPOST; O88668; -.
DR MaxQB; O88668; -.
DR PaxDb; O88668; -.
DR PeptideAtlas; O88668; -.
DR PRIDE; O88668; -.
DR ProteomicsDB; 285306; -.
DR Antibodypedia; 20531; 331 antibodies from 34 providers.
DR DNASU; 433375; -.
DR Ensembl; ENSMUST00000111432; ENSMUSP00000107060; ENSMUSG00000040713.
DR GeneID; 433375; -.
DR KEGG; mmu:433375; -.
DR UCSC; uc007djm.1; mouse.
DR CTD; 8804; -.
DR MGI; MGI:1344382; Creg1.
DR VEuPathDB; HostDB:ENSMUSG00000040713; -.
DR eggNOG; KOG3374; Eukaryota.
DR GeneTree; ENSGT00390000005914; -.
DR HOGENOM; CLU_083635_3_1_1; -.
DR InParanoid; O88668; -.
DR OMA; CAHIIFV; -.
DR OrthoDB; 1252017at2759; -.
DR PhylomeDB; O88668; -.
DR TreeFam; TF324680; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 433375; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Creg1; mouse.
DR PRO; PR:O88668; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; O88668; protein.
DR Bgee; ENSMUSG00000040713; Expressed in placenta labyrinth and 250 other tissues.
DR ExpressionAtlas; O88668; baseline and differential.
DR Genevisible; O88668; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
DR Gene3D; 2.30.110.10; -; 1.
DR InterPro; IPR014631; CREG.
DR InterPro; IPR012349; Split_barrel_FMN-bd.
DR PIRSF; PIRSF036911; CREG; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Growth regulation; Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..220
FT /note="Protein CREG1"
FT /id="PRO_0000006204"
FT REGION 30..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 62
FT /note="V -> M (in Ref. 2; BAC39549)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 220 AA; 24452 MW; EF3A8CFD3186163D CRC64;
MAARAPELAR SLLAALLAPA LVALLVSPAS GRGGRDHGDW DVDRRLPPLP PREDGPRVAR
FVTHVSDWGS LATISTIKEV RGWPFADIIS ISDGPPGEGT GEPYMYLSPL QQAVSDLQEN
PEATLTMSLA QTVYCRNHGF DPQSPLCVHI MMSGTVTKVN KTEEDYARDS LFVRHPEMKH
WPSSHNWFFA KLKISRIWVL DYFGGPKVVT PEEYFNVTLQ
