CREG2_HUMAN
ID CREG2_HUMAN Reviewed; 290 AA.
AC Q8IUH2; Q86X03; Q8N540; Q8N9E3;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein CREG2;
DE AltName: Full=Cellular repressor of E1A-stimulated genes 2 {ECO:0000303|PubMed:12408961};
DE Flags: Precursor;
GN Name=CREG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP GLYCOSYLATION, AND MUTAGENESIS OF 165-ASN-ASN-166.
RC TISSUE=Brain;
RX PubMed=12408961; DOI=10.1006/geno.2002.6857;
RA Kunita R., Otomo A., Ikeda J.-E.;
RT "Identification and characterization of novel members of the CREG family,
RT putative secreted glycoproteins expressed specifically in brain.";
RL Genomics 80:456-460(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-96.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-290, AND VARIANT GLN-96.
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12408961}.
CC -!- TISSUE SPECIFICITY: Brain specific mainly in the limbic system and
CC faintly in the spinal cord but not in cerebellum.
CC {ECO:0000269|PubMed:12408961}.
CC -!- PTM: It is not sure whether N-glycosylation is on Asn-165 and/or Asn-
CC 166. {ECO:0000269|PubMed:12408961}.
CC -!- SIMILARITY: Belongs to the CREG family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB046109; BAC22189.1; -; mRNA.
DR EMBL; BC032949; AAH32949.2; -; mRNA.
DR EMBL; BC047514; AAH47514.1; -; mRNA.
DR EMBL; AK094970; BAC04464.1; ALT_INIT; mRNA.
DR CCDS; CCDS2052.1; -.
DR RefSeq; NP_722578.1; NM_153836.3.
DR AlphaFoldDB; Q8IUH2; -.
DR SMR; Q8IUH2; -.
DR BioGRID; 128325; 13.
DR STRING; 9606.ENSP00000315203; -.
DR GlyGen; Q8IUH2; 2 sites.
DR iPTMnet; Q8IUH2; -.
DR PhosphoSitePlus; Q8IUH2; -.
DR BioMuta; CREG2; -.
DR DMDM; 59797946; -.
DR MassIVE; Q8IUH2; -.
DR PaxDb; Q8IUH2; -.
DR PeptideAtlas; Q8IUH2; -.
DR PRIDE; Q8IUH2; -.
DR ProteomicsDB; 70565; -.
DR Antibodypedia; 48936; 116 antibodies from 20 providers.
DR DNASU; 200407; -.
DR Ensembl; ENST00000324768.6; ENSP00000315203.4; ENSG00000175874.10.
DR GeneID; 200407; -.
DR KEGG; hsa:200407; -.
DR MANE-Select; ENST00000324768.6; ENSP00000315203.4; NM_153836.4; NP_722578.1.
DR UCSC; uc002tba.3; human.
DR CTD; 200407; -.
DR GeneCards; CREG2; -.
DR HGNC; HGNC:14272; CREG2.
DR HPA; ENSG00000175874; Tissue enriched (brain).
DR MIM; 618540; gene.
DR neXtProt; NX_Q8IUH2; -.
DR OpenTargets; ENSG00000175874; -.
DR PharmGKB; PA134876243; -.
DR VEuPathDB; HostDB:ENSG00000175874; -.
DR eggNOG; KOG3374; Eukaryota.
DR GeneTree; ENSGT00390000005914; -.
DR HOGENOM; CLU_083635_0_0_1; -.
DR InParanoid; Q8IUH2; -.
DR OMA; PRHYEWF; -.
DR OrthoDB; 1252017at2759; -.
DR PhylomeDB; Q8IUH2; -.
DR TreeFam; TF324680; -.
DR PathwayCommons; Q8IUH2; -.
DR BioGRID-ORCS; 200407; 14 hits in 1069 CRISPR screens.
DR ChiTaRS; CREG2; human.
DR GenomeRNAi; 200407; -.
DR Pharos; Q8IUH2; Tdark.
DR PRO; PR:Q8IUH2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8IUH2; protein.
DR Bgee; ENSG00000175874; Expressed in Brodmann (1909) area 46 and 125 other tissues.
DR Genevisible; Q8IUH2; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR Gene3D; 2.30.110.10; -; 1.
DR InterPro; IPR014631; CREG.
DR InterPro; IPR012349; Split_barrel_FMN-bd.
DR PIRSF; PIRSF036911; CREG; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..290
FT /note="Protein CREG2"
FT /id="PRO_0000006206"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305|PubMed:12408961"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305|PubMed:12408961"
FT VARIANT 96
FT /note="P -> Q (in dbSNP:rs11554173)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_021252"
FT MUTAGEN 165..166
FT /note="NN->QQ: Abolishes N-glycosylation."
FT /evidence="ECO:0000269|PubMed:12408961"
SQ SEQUENCE 290 AA; 32109 MW; 70E9DBC6FCE3BD64 CRC64;
MSVRRGRRPA RPGTRLSWLL CCSALLSPAA GYVIVSSVSW AVTNEVDEEL DSASTEEAMP
ALLEDSGSIW QQSFPASAHK EDAHLRPRAG AARARPPPAP PGMFSYRREG GQTASAPPGP
RLRAATARSL AHASVWGCLA TVSTHKKIQG LPFGNCLPVS DGPFNNSTGI PFFYMTAKDP
VVADLMKNPM ASLMLPESEG EFCRKNIVDP EDPRCVQLTL TGQMIAVSPE EVEFAKQAMF
SRHPGMRKWP RQYEWFFMKM RIEHIWLQKW YGGASSISRE EYFKAVPRKA
