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CREG2_MOUSE
ID   CREG2_MOUSE             Reviewed;         288 AA.
AC   Q8BGC9; Q14AL7; Q8BL64; Q8BX89; Q8K049;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Protein CREG2;
DE   AltName: Full=Cellular repressor of E1A-stimulated genes 2 {ECO:0000303|PubMed:12408961};
DE   Flags: Precursor;
GN   Name=Creg2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION,
RP   GLYCOSYLATION, AND MUTAGENESIS OF 164-ASN--ASN-186.
RC   TISSUE=Brain;
RX   PubMed=12408961; DOI=10.1006/geno.2002.6857;
RA   Kunita R., Otomo A., Ikeda J.-E.;
RT   "Identification and characterization of novel members of the CREG family,
RT   putative secreted glycoproteins expressed specifically in brain.";
RL   Genomics 80:456-460(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12408961}.
CC   -!- TISSUE SPECIFICITY: Brain specific. {ECO:0000269|PubMed:12408961}.
CC   -!- SIMILARITY: Belongs to the CREG family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC32652.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC33382.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB046110; BAC22190.1; -; mRNA.
DR   EMBL; AK043871; BAC31687.1; -; mRNA.
DR   EMBL; AK044192; BAC31811.1; -; mRNA.
DR   EMBL; AK046245; BAC32652.1; ALT_INIT; mRNA.
DR   EMBL; AK048589; BAC33382.1; ALT_FRAME; mRNA.
DR   EMBL; BC034115; AAH34115.1; -; mRNA.
DR   EMBL; BC116790; AAI16791.1; -; mRNA.
DR   EMBL; BC116792; AAI16793.1; -; mRNA.
DR   CCDS; CCDS14908.1; -.
DR   RefSeq; NP_733485.1; NM_170597.4.
DR   AlphaFoldDB; Q8BGC9; -.
DR   SMR; Q8BGC9; -.
DR   STRING; 10090.ENSMUSP00000052871; -.
DR   GlyConnect; 2621; 1 N-Linked glycan (1 site).
DR   GlyGen; Q8BGC9; 1 site, 1 N-linked glycan (1 site).
DR   iPTMnet; Q8BGC9; -.
DR   PhosphoSitePlus; Q8BGC9; -.
DR   MaxQB; Q8BGC9; -.
DR   PaxDb; Q8BGC9; -.
DR   PRIDE; Q8BGC9; -.
DR   ProteomicsDB; 285358; -.
DR   Antibodypedia; 48936; 116 antibodies from 20 providers.
DR   DNASU; 263764; -.
DR   Ensembl; ENSMUST00000053355; ENSMUSP00000052871; ENSMUSG00000050967.
DR   GeneID; 263764; -.
DR   KEGG; mmu:263764; -.
DR   UCSC; uc007atm.1; mouse.
DR   CTD; 200407; -.
DR   MGI; MGI:1928333; Creg2.
DR   VEuPathDB; HostDB:ENSMUSG00000050967; -.
DR   eggNOG; KOG3374; Eukaryota.
DR   GeneTree; ENSGT00390000005914; -.
DR   HOGENOM; CLU_083635_0_0_1; -.
DR   InParanoid; Q8BGC9; -.
DR   OMA; PRHYEWF; -.
DR   OrthoDB; 1252017at2759; -.
DR   PhylomeDB; Q8BGC9; -.
DR   TreeFam; TF324680; -.
DR   BioGRID-ORCS; 263764; 2 hits in 73 CRISPR screens.
DR   PRO; PR:Q8BGC9; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q8BGC9; protein.
DR   Bgee; ENSMUSG00000050967; Expressed in lumbar subsegment of spinal cord and 77 other tissues.
DR   Genevisible; Q8BGC9; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR   Gene3D; 2.30.110.10; -; 1.
DR   InterPro; IPR014631; CREG.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   PIRSF; PIRSF036911; CREG; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..288
FT                   /note="Protein CREG2"
FT                   /id="PRO_0000006207"
FT   REGION          78..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:12408961"
FT   MUTAGEN         164..186
FT                   /note="NSTGIPFFYMTAKDPAVADLVKN->QSTGIPFFYMTAKDPAVADLVKQ:
FT                   Abolishes N-glycosylation."
FT                   /evidence="ECO:0000269|PubMed:12408961"
FT   MUTAGEN         164
FT                   /note="N->Q: Abolishes N-glycosylation."
FT   MUTAGEN         186
FT                   /note="N->Q: N-glycosylated."
FT   CONFLICT        25..28
FT                   /note="LLSP -> DAWA (in Ref. 3; AAH34115)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51
FT                   /note="D -> E (in Ref. 2; BAC33382)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266
FT                   /note="Q -> H (in Ref. 2; BAC33382)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  31764 MW;  A73A97E7BBB1C60E CRC64;
     MSLSGRERPA WPGSRLSWLL CCSALLSPAA GYVIVSSVSW AVTNEVDEEL DSASTEEALP
     ALLEDSSSIW QQSFPASAHK EDTHLRPRGS ARARPAPAAR GMFSYRRESG SSEASPGPRV
     HAGTARSLAH ASSWGCLATV STHEKIQGLP FGSCLAISDG PVHNSTGIPF FYMTAKDPAV
     ADLVKNPTAS LVLPESEGEF CRKNIVDPED PRCARLTLTG RMVTVPPGEV EFAKQAMFSR
     HPGMRKWPRQ YEWFFMKMWV EHIWLQKWYG GVSDIPREEY FKAAPRKA
 
 
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