CREL2_DANRE
ID CREL2_DANRE Reviewed; 341 AA.
AC Q7SXF6; Q5RFU8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Cysteine-rich with EGF-like domain protein 2;
DE Flags: Precursor;
GN Name=creld2; ORFNames=zgc:66383;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possible role in neuronal acetylcholine receptor transport.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
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DR EMBL; CR751234; CAI20713.1; -; Genomic_DNA.
DR EMBL; BC055626; AAH55626.1; -; mRNA.
DR RefSeq; NP_956817.1; NM_200523.1.
DR AlphaFoldDB; Q7SXF6; -.
DR STRING; 7955.ENSDARP00000048382; -.
DR PaxDb; Q7SXF6; -.
DR PeptideAtlas; Q7SXF6; -.
DR Ensembl; ENSDART00000048383; ENSDARP00000048382; ENSDARG00000029071.
DR Ensembl; ENSDART00000193547; ENSDARP00000146751; ENSDARG00000116264.
DR GeneID; 393495; -.
DR KEGG; dre:393495; -.
DR CTD; 79174; -.
DR ZFIN; ZDB-GENE-040426-1626; creld2.
DR eggNOG; KOG4260; Eukaryota.
DR GeneTree; ENSGT00940000160071; -.
DR HOGENOM; CLU_038974_1_0_1; -.
DR InParanoid; Q7SXF6; -.
DR OMA; DQEACVD; -.
DR OrthoDB; 883628at2759; -.
DR PhylomeDB; Q7SXF6; -.
DR TreeFam; TF316507; -.
DR PRO; PR:Q7SXF6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000029071; Expressed in tail and 22 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00064; FU; 2.
DR InterPro; IPR021852; DUF3456.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR Pfam; PF11938; DUF3456; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00261; FU; 2.
DR SUPFAM; SSF57184; SSF57184; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 2.
PE 2: Evidence at transcript level;
KW Calcium; Disulfide bond; EGF-like domain; Endoplasmic reticulum;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..341
FT /note="Cysteine-rich with EGF-like domain protein 2"
FT /id="PRO_0000256248"
FT DOMAIN 136..178
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 193..248
FT /note="FU 1"
FT REPEAT 254..308
FT /note="FU 2"
FT DOMAIN 291..317
FT /note="EGF-like 2; calcium-binding; truncated"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 140..154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 148..166
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 168..177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CONFLICT 78
FT /note="I -> T (in Ref. 2; AAH55626)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="F -> S (in Ref. 2; AAH55626)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 341 AA; 37603 MW; 626565A690D57C07 CRC64;
MLLSCSIFRL FCIILLLQLG SIYTKDFTAL CSTCRQLVDD FDKGLEKTAK QNFGGGNTAW
EERKLSKYET SEIRLTEILE GLCQSSNFEC SHMLEENEEH LEAWWFKRKT KHPDLFKWFC
IETIKVCCPK GSFGPDCNTC IGGADRPCHG NGKCDGDGTR AGNGKCSCDE GYDGEFCLDC
SDGYFNSLRN DTFFLCKECH ESCVGCSGGT NQHCKECRNG WVKDQEGSCI DINECIKDPA
PCSDDQYCLN TDGSFSCKAC DIRCTGCKGD GASSCLNCAD GYKDEEGTCT DIDECTEDPA
SCSDNQHCLN TDGSFSCEEK VPAFNSEGAK TGDSPEKHED L
