CREM_BOVIN
ID CREM_BOVIN Reviewed; 360 AA.
AC Q1LZH5; Q3SZW5;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=cAMP-responsive element modulator;
GN Name=CREM;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Crossbred X Angus, and Hereford; TISSUE=Liver, and Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator that binds the cAMP response
CC element (CRE), a sequence present in many viral and cellular promoters.
CC Isoforms are either transcriptional activators or repressors. Isoform 1
CC and isoform 2 are transcriptional activators. Plays a role in
CC spermatogenesis and is involved in spermatid maturation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a dimer. Interacts with FHL5. Interacts with
CC CDC34. May interact with TSSK4. {ECO:0000250|UniProtKB:P27699,
CC ECO:0000250|UniProtKB:Q03060}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312,
CC ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage; Named isoforms=2;
CC Comment=Additional isoforms seem to exist.;
CC Name=1;
CC IsoId=Q1LZH5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1LZH5-2; Sequence=VSP_025033, VSP_025034;
CC -!- PTM: Stimulated by phosphorylation. Phosphorylated on Ser-118 by TSSK4
CC in vitro. {ECO:0000250|UniProtKB:P27699, ECO:0000250|UniProtKB:Q01147}.
CC -!- MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.
CC Activator.
CC -!- MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage.
CC Activator. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; BC102677; AAI02678.1; -; mRNA.
DR EMBL; BC115995; AAI15996.1; -; mRNA.
DR RefSeq; NP_001029882.2; NM_001034710.3. [Q1LZH5-1]
DR RefSeq; XP_005214310.1; XM_005214253.3. [Q1LZH5-2]
DR AlphaFoldDB; Q1LZH5; -.
DR SMR; Q1LZH5; -.
DR STRING; 9913.ENSBTAP00000021381; -.
DR PaxDb; Q1LZH5; -.
DR PRIDE; Q1LZH5; -.
DR Ensembl; ENSBTAT00000021381; ENSBTAP00000021381; ENSBTAG00000016060. [Q1LZH5-1]
DR Ensembl; ENSBTAT00000055517; ENSBTAP00000050114; ENSBTAG00000016060. [Q1LZH5-2]
DR GeneID; 540605; -.
DR KEGG; bta:540605; -.
DR CTD; 1390; -.
DR VEuPathDB; HostDB:ENSBTAG00000016060; -.
DR eggNOG; KOG3584; Eukaryota.
DR GeneTree; ENSGT00940000156952; -.
DR HOGENOM; CLU_042675_0_1_1; -.
DR InParanoid; Q1LZH5; -.
DR OMA; MSKCSRK; -.
DR OrthoDB; 957343at2759; -.
DR TreeFam; TF106464; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000016060; Expressed in spermatid and 106 other tissues.
DR ExpressionAtlas; Q1LZH5; differential.
DR GO; GO:1990589; C:ATF4-CREB1 transcription factor complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR003102; Coactivator_CBP_pKID.
DR InterPro; IPR001630; Leuzip_CREB.
DR PANTHER; PTHR45879; PTHR45879; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF02173; pKID; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS50953; KID; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative promoter usage; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..360
FT /note="cAMP-responsive element modulator"
FT /id="PRO_0000286357"
FT DOMAIN 104..163
FT /note="KID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00312"
FT DOMAIN 302..360
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 19..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..328
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 330..351
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P27699"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q03060"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q03060,
FT ECO:0000255|PROSITE-ProRule:PRU00312"
FT MOD_RES 290
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q03060,
FT ECO:0000255|PROSITE-ProRule:PRU00312"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q03060,
FT ECO:0000255|PROSITE-ProRule:PRU00312"
FT VAR_SEQ 1..55
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_025033"
FT VAR_SEQ 56
FT /note="Q -> M (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_025034"
FT CONFLICT 249
FT /note="D -> G (in Ref. 1; AAI02678)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 360 AA; 38694 MW; 78C5E242D95536DE CRC64;
MSKCGRKKYM KTNLRQMTME TIDSQQDGSL PDSVAESESA HMQTQTGQNS IPTLAQVSVA
GSSTGRGSPA VTLVQLPSGQ TVHVQGVIQT PQPSVIQSPQ IQTVQVATIA ETDESAESEG
VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEEKSE EEGTPPNIAA MAVPTSIYQT
STGQYIAIAQ GGTIQISNPG SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV
PGSQVVVQDE ETELAPSHMA AATGDMPTYQ IRAPTTALPQ GVVMAASPGS LHSPQQLAEE
ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET LKDICSPKTD
