CREM_HUMAN
ID CREM_HUMAN Reviewed; 345 AA.
AC Q03060; A8K014; A8K3J7; A8K6A1; A8MPQ2; B4DXC1; C9J785; C9JZ10; E9PAR4;
AC E9PHM1; O75519; Q14501; Q14503; Q14504; Q14505; Q14506; Q15731; Q16114;
AC Q16116; Q5T9H7; Q5W1A6; Q5W1A7; Q5W1A8; Q5W1A9; Q5W1B0; Q5W1B2; Q7Z2Q6;
AC Q8IVD4; Q96AG7; Q9NZ98; Q9NZ99; Q9NZB9;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 6.
DT 03-AUG-2022, entry version 208.
DE RecName: Full=cAMP-responsive element modulator {ECO:0000305};
DE AltName: Full=Inducible cAMP early repressor;
DE Short=ICER;
GN Name=CREM {ECO:0000312|HGNC:HGNC:2352};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
RX PubMed=7916662;
RA Masquilier D., Foulkes N.S., Mattei M.-G., Sassone-Corsi P.;
RT "Human CREM gene: evolutionary conservation, chromosomal localization, and
RT inducibility of the transcript.";
RL Cell Growth Differ. 4:931-937(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 7; 8; 9 AND 23).
RX PubMed=8206879; DOI=10.1093/oxfordjournals.jbchem.a124332;
RA Fujimoto T., Fujisawa J., Yoshida M.;
RT "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM)
RT mRNA.";
RL J. Biochem. 115:298-303(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), ALTERNATIVE SPLICING (ISOFORMS 6; 7
RP AND 9), AND VARIANT ARG-254.
RX PubMed=8622971; DOI=10.1073/pnas.93.8.3536;
RA Bodor J., Spetz A.L., Strominger J.L., Habener J.F.;
RT "cAMP inducibility of transcriptional repressor ICER in developing and
RT mature human T lymphocytes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:3536-3541(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
RA Brodie C.R., Boland L.M., Orr H.T.;
RT "Human ICER1, a predicted alternative splice form of CREM, is evident in
RT JEG-3 cells.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
RC TISSUE=Testis;
RA Lu L., Huang X.Y., Xu M., Xu Z.Y., Li J.M., Zhou Z.M., Sha J.H.;
RT "The function of an isoform of hCREM gene in testis development.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 7; 20 AND 21).
RC TISSUE=Adrenal gland, Heart, Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 22).
RC TISSUE=Brain, Testis, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-232.
RA Vouk K., Lalli E., Scherer S.W., Sassone-Corsi P., Debeljak N., Komel R.,
RA Rozman D.;
RT "Searching for mutations in the human cAMP responsive element modulator
RT (CREM) gene.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-10 (ISOFORM 10), AND ALTERNATIVE SPLICING
RP (ISOFORMS 5; 10; 11 AND 12).
RX PubMed=12397208; DOI=10.1093/molehr/8.11.965;
RA Gellersen B., Kempf R., Sandhowe R., Weinbauer G.F., Behr R.;
RT "Novel leader exons of the cyclic adenosine 3',5'-monophosphate response
RT element modulator (CREM) gene, transcribed from promoters P3 and P4, are
RT highly testis-specific in primates.";
RL Mol. Hum. Reprod. 8:965-976(2002).
RN [11]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-344 (ISOFORM 4).
RC TISSUE=Placenta;
RX PubMed=1461747; DOI=10.1093/nar/20.22.6106;
RA Meyer T.E., Habener J.F.;
RT "Cyclic AMP response element binding protein CREB and modulator protein
RT CREM are products of distinct genes.";
RL Nucleic Acids Res. 20:6106-6106(1992).
RN [12]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 246-345, AND TISSUE SPECIFICITY.
RX PubMed=16143638; DOI=10.1093/molehr/gah209;
RA Vouk K., Hudler P., Strmsnik L., Fink M., Majdic G., Zorn B., Lalli E.,
RA Sassone-Corsi P., Debeljak N., Komel R., Rozman D.;
RT "Combinations of genetic changes in the human cAMP-responsive element
RT modulator gene: a clue towards understanding some forms of male
RT infertility?";
RL Mol. Hum. Reprod. 11:567-574(2005).
RN [13]
RP FUNCTION, INTERACTION WITH CDC34, AND UBIQUITINATION.
RX PubMed=10373550; DOI=10.1128/mcb.19.7.5001;
RA Pati D., Meistrich M.L., Plon S.E.;
RT "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of
RT cyclic AMP-induced transcription for proteolysis.";
RL Mol. Cell. Biol. 19:5001-5013(1999).
RN [14]
RP ALTERNATIVE SPLICING (ISOFORMS 2; 4; 13; 15; 17 AND 18), AND TISSUE
RP SPECIFICITY.
RX PubMed=11044457; DOI=10.1093/molehr/6.11.967;
RA Behr R., Weinbauer G.F.;
RT "CREM activator and repressor isoforms in human testis: sequence variations
RT and inaccurate splicing during impaired spermatogenesis.";
RL Mol. Hum. Reprod. 6:967-972(2000).
RN [15]
RP ALTERNATIVE SPLICING (ISOFORMS 5; 12; 14; 16 AND 19), AND TISSUE
RP SPECIFICITY.
RX PubMed=14511788; DOI=10.1016/s0093-691x(03)00142-0;
RA Bloecher S., Behr R., Weinbauer G.F., Bergmann M., Steger K.;
RT "Different CREM-isoform gene expression between equine and human normal and
RT impaired spermatogenesis.";
RL Theriogenology 60:1357-1369(2003).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271; SER-274 AND SER-277, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [17]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271 AND SER-277, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [18]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [19]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Transcriptional regulator that binds the cAMP response
CC element (CRE), a sequence present in many viral and cellular promoters.
CC Isoforms are either transcriptional activators or repressors. Plays a
CC role in spermatogenesis and is involved in spermatid maturation
CC (PubMed:10373550). {ECO:0000269|PubMed:10373550}.
CC -!- FUNCTION: [Isoform 6]: May play a role in the regulation of the
CC circadian clock: acts as a transcriptional repressor of the core
CC circadian component PER1 by directly binding to cAMP response elements
CC in its promoter. {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a dimer. Interacts with FHL5 (By similarity).
CC Interacts with CDC34 (PubMed:10373550). May interact with TSSK4 (By
CC similarity). {ECO:0000250, ECO:0000250|UniProtKB:P27699,
CC ECO:0000269|PubMed:10373550}.
CC -!- INTERACTION:
CC Q03060; Q9Y6K1: DNMT3A; NbExp=2; IntAct=EBI-3907794, EBI-923653;
CC Q03060-25; P46379-2: BAG6; NbExp=3; IntAct=EBI-12884642, EBI-10988864;
CC Q03060-25; O14503: BHLHE40; NbExp=3; IntAct=EBI-12884642, EBI-711810;
CC Q03060-25; P22607: FGFR3; NbExp=3; IntAct=EBI-12884642, EBI-348399;
CC Q03060-25; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-12884642, EBI-7251368;
CC Q03060-25; P84074: HPCA; NbExp=6; IntAct=EBI-12884642, EBI-12197079;
CC Q03060-25; P37235: HPCAL1; NbExp=6; IntAct=EBI-12884642, EBI-749311;
CC Q03060-25; Q9BUB5: MKNK1; NbExp=3; IntAct=EBI-12884642, EBI-73837;
CC Q03060-25; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-12884642, EBI-5662487;
CC Q03060-25; P61601: NCALD; NbExp=5; IntAct=EBI-12884642, EBI-749635;
CC Q03060-25; P62166: NCS1; NbExp=3; IntAct=EBI-12884642, EBI-746987;
CC Q03060-25; P14859-6: POU2F1; NbExp=3; IntAct=EBI-12884642, EBI-11526590;
CC Q03060-25; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-12884642, EBI-372094;
CC Q03060-25; Q01974: ROR2; NbExp=3; IntAct=EBI-12884642, EBI-6422642;
CC Q03060-25; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-12884642, EBI-6257312;
CC Q03060-25; P14678-2: SNRPB; NbExp=3; IntAct=EBI-12884642, EBI-372475;
CC Q03060-25; P09234: SNRPC; NbExp=3; IntAct=EBI-12884642, EBI-766589;
CC Q03060-25; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-12884642, EBI-2514383;
CC Q03060-25; O95231: VENTX; NbExp=3; IntAct=EBI-12884642, EBI-10191303;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=29;
CC Name=1; Synonyms=CREM-BCEFGgammaHIbeta;
CC IsoId=Q03060-5; Sequence=Displayed;
CC Name=2; Synonyms=Beta, CREM-BCEFGHIbeta;
CC IsoId=Q03060-1; Sequence=VSP_059705, VSP_059715;
CC Name=3; Synonyms=CREM-BCEFGIalpha, Tau;
CC IsoId=Q03060-6; Sequence=VSP_059705, VSP_059715, VSP_059717;
CC Name=4; Synonyms=Alpha, CREM-BEFHIb, CREM-gamma;
CC IsoId=Q03060-2; Sequence=VSP_059705, VSP_059708, VSP_059709;
CC Name=5; Synonyms=CREM-theta2tau-gamma, CREM-theta2EFGHIb;
CC IsoId=Q03060-7; Sequence=VSP_059704, VSP_059715;
CC Name=6; Synonyms=CREM2alpha-a, IcergammaHIalpha, ICER1, ICERI;
CC IsoId=Q03060-8; Sequence=VSP_059701, VSP_059717;
CC Name=7; Synonyms=CREM2alpha-b, IcerHIalpha, ICERIgamma;
CC IsoId=Q03060-9; Sequence=VSP_059698, VSP_059717;
CC Name=8; Synonyms=CREM 2beta-a, IcergammaHIbeta, ICERII;
CC IsoId=Q03060-10; Sequence=VSP_059701;
CC Name=9; Synonyms=CREM 2beta-b, IcerHIbeta, ICERIIgamma;
CC IsoId=Q03060-11; Sequence=VSP_059698;
CC Name=10; Synonyms=CREMtheta1tau2beta, CREM-theta1EFGHIbeta;
CC IsoId=Q03060-12; Sequence=VSP_059703, VSP_059715;
CC Name=11; Synonyms=CREM-theta1beta, CREM-theta1EFHIbeta;
CC IsoId=Q03060-13; Sequence=VSP_059703, VSP_059712, VSP_059716;
CC Name=12; Synonyms=CREM-theta2beta, CREM-theta2EFHIb, CREM-theta2-gamma;
CC IsoId=Q03060-14; Sequence=VSP_059704, VSP_059712, VSP_059716;
CC Name=13; Synonyms=CREM-BEFGgammaHIbeta;
CC IsoId=Q03060-15; Sequence=VSP_059705, VSP_059708;
CC Name=14; Synonyms=CREM-tau2-gamma, CREM-BEFGHIbeta;
CC IsoId=Q03060-16; Sequence=VSP_059705, VSP_059708, VSP_059715;
CC Name=15; Synonyms=CREM-BGHIbeta;
CC IsoId=Q03060-17; Sequence=VSP_059705, VSP_059707, VSP_059715;
CC Name=16; Synonyms=CREM-deltaC-G, CREM-BgammaHIbeta;
CC IsoId=Q03060-19; Sequence=VSP_059705, VSP_059706;
CC Name=17; Synonyms=CREM-BHIbeta;
CC IsoId=Q03060-20; Sequence=VSP_059705, VSP_059710;
CC Name=18; Synonyms=CREM-BHIalpha;
CC IsoId=Q03060-21; Sequence=VSP_059705, VSP_059710, VSP_059717;
CC Name=19; Synonyms=CREM-theta1tau2gamma, CREM-theta1EFGgammaHIbeta;
CC IsoId=Q03060-22; Sequence=VSP_059703;
CC Name=20;
CC IsoId=Q03060-23; Sequence=VSP_059699, VSP_059717;
CC Name=21;
CC IsoId=Q03060-24; Sequence=VSP_059697, VSP_059717;
CC Name=22;
CC IsoId=Q03060-25; Sequence=VSP_059708, VSP_059713, VSP_059714;
CC Name=23;
CC IsoId=Q03060-26; Sequence=VSP_059705, VSP_059708, VSP_059711,
CC VSP_059717;
CC Name=24;
CC IsoId=Q03060-27; Sequence=VSP_059697;
CC Name=25;
CC IsoId=Q03060-28; Sequence=VSP_059702, VSP_059715;
CC Name=26;
CC IsoId=Q03060-29; Sequence=VSP_059700;
CC Name=27;
CC IsoId=Q03060-30; Sequence=VSP_059708, VSP_059709;
CC Name=28;
CC IsoId=Q03060-31; Sequence=VSP_059705, VSP_059708, VSP_059715,
CC VSP_059717;
CC Name=29;
CC IsoId=Q03060-32; Sequence=VSP_059705, VSP_059708, VSP_059709,
CC VSP_059717;
CC -!- TISSUE SPECIFICITY: Expressed in testes (round spermatids) (at protein
CC level). Isoform 14 is the major activator form in testes.
CC {ECO:0000269|PubMed:11044457, ECO:0000269|PubMed:14511788,
CC ECO:0000269|PubMed:16143638}.
CC -!- PTM: Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be
CC degraded by the proteasome. {ECO:0000269|PubMed:10373550}.
CC -!- PTM: Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4
CC in vitro. {ECO:0000250|UniProtKB:P27699, ECO:0000250|UniProtKB:Q01147}.
CC -!- MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.
CC -!- MISCELLANEOUS: [Isoform 2]: Produced by alternative splicing of isoform
CC 1. Activator. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform
CC 1. Activator. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform
CC 1. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 5]: Produced by alternative promoter usage.
CC Activator. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 6]: Produced by alternative promoter usage.
CC Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 7]: Produced by alternative splicing of isoform
CC 6. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 8]: Produced by alternative splicing of isoform
CC 6. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 9]: Produced by alternative splicing of isoform
CC 6. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 10]: Produced by alternative promoter usage.
CC Activator. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 11]: Produced by alternative splicing of
CC isoform 10. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 12]: Produced by alternative splicing of
CC isoform 5. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 13]: Produced by alternative splicing of
CC isoform 1. Activator. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 14]: Produced by alternative splicing of
CC isoform 1. Activator. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 15]: Produced by alternative splicing of
CC isoform 1. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 16]: Produced by alternative splicing of
CC isoform 1. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 17]: Produced by alternative splicing of
CC isoform 1. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 18]: Produced by alternative splicing of
CC isoform 1. Repressor. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 19]: Produced by alternative splicing of
CC isoform 10. Activator. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 24]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 25]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 26]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 27]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 28]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 29]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB03751.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AAF68266.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; D14825; BAA03562.1; -; mRNA.
DR EMBL; D14826; BAA03564.1; -; mRNA.
DR EMBL; D14826; BAA03565.1; -; mRNA.
DR EMBL; D14826; BAA03566.1; -; mRNA.
DR EMBL; D14826; BAA03567.1; -; mRNA.
DR EMBL; U44836; AAB03751.1; ALT_SEQ; mRNA.
DR EMBL; AF069065; AAC19383.1; -; mRNA.
DR EMBL; AY292864; AAP44115.1; -; mRNA.
DR EMBL; AK289379; BAF82068.1; -; mRNA.
DR EMBL; AK290612; BAF83301.1; -; mRNA.
DR EMBL; AK291566; BAF84255.1; -; mRNA.
DR EMBL; AK301906; BAG63333.1; -; mRNA.
DR EMBL; AL117336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL157783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW85917.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW85918.1; -; Genomic_DNA.
DR EMBL; BC017117; AAH17117.1; -; mRNA.
DR EMBL; BC066342; AAH66342.1; -; mRNA.
DR EMBL; BC090051; AAH90051.1; -; mRNA.
DR EMBL; AF213899; AAF68266.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AF212158; AAF68266.2; JOINED; Genomic_DNA.
DR EMBL; AF213897; AAF68266.2; JOINED; Genomic_DNA.
DR EMBL; AF213898; AAF68266.2; JOINED; Genomic_DNA.
DR EMBL; AF417234; AAN32656.1; -; mRNA.
DR EMBL; S68271; AAC60616.2; -; mRNA.
DR EMBL; S68134; AAC60617.2; -; mRNA.
DR EMBL; Z15159; CAA78858.1; -; mRNA.
DR EMBL; AF217318; AAF66158.2; -; Genomic_DNA.
DR EMBL; AF214665; AAF66158.2; JOINED; Genomic_DNA.
DR EMBL; AF217318; AAF68682.1; -; Genomic_DNA.
DR EMBL; AF214665; AAF68682.1; JOINED; Genomic_DNA.
DR CCDS; CCDS31181.1; -. [Q03060-32]
DR CCDS; CCDS53517.1; -. [Q03060-10]
DR CCDS; CCDS53518.1; -. [Q03060-9]
DR CCDS; CCDS53519.1; -. [Q03060-11]
DR CCDS; CCDS53520.1; -. [Q03060-27]
DR CCDS; CCDS53521.1; -. [Q03060-23]
DR CCDS; CCDS58074.1; -. [Q03060-22]
DR CCDS; CCDS58075.1; -. [Q03060-28]
DR CCDS; CCDS58076.1; -. [Q03060-29]
DR CCDS; CCDS7180.1; -. [Q03060-16]
DR CCDS; CCDS7181.1; -. [Q03060-31]
DR CCDS; CCDS7182.1; -. [Q03060-26]
DR CCDS; CCDS7183.1; -. [Q03060-30]
DR CCDS; CCDS7184.1; -. [Q03060-25]
DR CCDS; CCDS7185.1; -. [Q03060-12]
DR CCDS; CCDS7186.1; -. [Q03060-7]
DR CCDS; CCDS7187.1; -. [Q03060-8]
DR CCDS; CCDS7188.1; -. [Q03060-24]
DR PIR; JC2087; JC2087.
DR PIR; JC6135; JC6135.
DR PIR; JX0307; JX0307.
DR PIR; S26685; S26685.
DR RefSeq; NP_001254491.1; NM_001267562.1.
DR RefSeq; NP_001254493.1; NM_001267564.1. [Q03060-22]
DR RefSeq; NP_001254496.1; NM_001267567.1. [Q03060-28]
DR RefSeq; NP_001254499.1; NM_001267570.1. [Q03060-29]
DR RefSeq; NP_001872.3; NM_001881.3. [Q03060-25]
DR RefSeq; NP_853549.1; NM_181571.2. [Q03060-16]
DR RefSeq; NP_874386.1; NM_182717.1. [Q03060-8]
DR RefSeq; NP_874387.1; NM_182718.1. [Q03060-11]
DR RefSeq; NP_874388.1; NM_182719.1. [Q03060-10]
DR RefSeq; NP_874389.1; NM_182720.1. [Q03060-9]
DR RefSeq; NP_874390.1; NM_182721.1. [Q03060-24]
DR RefSeq; NP_874392.1; NM_182723.1. [Q03060-23]
DR RefSeq; NP_874393.1; NM_182724.1. [Q03060-27]
DR RefSeq; NP_877570.1; NM_182769.2. [Q03060-7]
DR RefSeq; NP_877571.1; NM_182770.2.
DR RefSeq; NP_877572.1; NM_182771.1. [Q03060-12]
DR RefSeq; NP_877573.1; NM_182772.1.
DR RefSeq; NP_898829.1; NM_183011.1. [Q03060-31]
DR RefSeq; NP_898830.1; NM_183012.1. [Q03060-32]
DR RefSeq; NP_898831.1; NM_183013.2. [Q03060-26]
DR RefSeq; NP_898883.1; NM_183060.2. [Q03060-30]
DR RefSeq; XP_006717441.1; XM_006717378.3. [Q03060-16]
DR RefSeq; XP_006717442.1; XM_006717379.3. [Q03060-31]
DR RefSeq; XP_006717445.1; XM_006717382.3. [Q03060-2]
DR RefSeq; XP_006717446.1; XM_006717383.3. [Q03060-32]
DR RefSeq; XP_011517626.1; XM_011519324.2. [Q03060-15]
DR RefSeq; XP_011517627.1; XM_011519325.2. [Q03060-15]
DR RefSeq; XP_016871211.1; XM_017015722.1. [Q03060-30]
DR AlphaFoldDB; Q03060; -.
DR SMR; Q03060; -.
DR BioGRID; 107780; 44.
DR IntAct; Q03060; 33.
DR MINT; Q03060; -.
DR GlyGen; Q03060; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q03060; -.
DR PhosphoSitePlus; Q03060; -.
DR BioMuta; CREM; -.
DR DMDM; 259016392; -.
DR EPD; Q03060; -.
DR jPOST; Q03060; -.
DR MassIVE; Q03060; -.
DR MaxQB; Q03060; -.
DR PeptideAtlas; Q03060; -.
DR PRIDE; Q03060; -.
DR ProteomicsDB; 12335; -.
DR ProteomicsDB; 19066; -.
DR ProteomicsDB; 1908; -.
DR ProteomicsDB; 20564; -.
DR ProteomicsDB; 58163; -. [Q03060-5]
DR ProteomicsDB; 58164; -. [Q03060-1]
DR ProteomicsDB; 58165; -. [Q03060-10]
DR ProteomicsDB; 58166; -. [Q03060-11]
DR ProteomicsDB; 58167; -. [Q03060-12]
DR ProteomicsDB; 58168; -. [Q03060-13]
DR ProteomicsDB; 58169; -. [Q03060-14]
DR ProteomicsDB; 58170; -. [Q03060-15]
DR ProteomicsDB; 58171; -. [Q03060-16]
DR ProteomicsDB; 58172; -. [Q03060-17]
DR ProteomicsDB; 58173; -. [Q03060-19]
DR ProteomicsDB; 58174; -. [Q03060-2]
DR ProteomicsDB; 58175; -. [Q03060-20]
DR ProteomicsDB; 58176; -. [Q03060-21]
DR ProteomicsDB; 58177; -. [Q03060-22]
DR ProteomicsDB; 58178; -. [Q03060-23]
DR ProteomicsDB; 58179; -. [Q03060-24]
DR ProteomicsDB; 58180; -. [Q03060-25]
DR ProteomicsDB; 58181; -. [Q03060-6]
DR ProteomicsDB; 58182; -. [Q03060-7]
DR ProteomicsDB; 58183; -. [Q03060-8]
DR ProteomicsDB; 58184; -. [Q03060-9]
DR ProteomicsDB; 65804; -.
DR ProteomicsDB; 65805; -.
DR ProteomicsDB; 8870; -.
DR Antibodypedia; 4333; 434 antibodies from 36 providers.
DR DNASU; 1390; -.
DR Ensembl; ENST00000337656.8; ENSP00000337138.4; ENSG00000095794.20. [Q03060-31]
DR Ensembl; ENST00000342105.7; ENSP00000341875.3; ENSG00000095794.20. [Q03060-7]
DR Ensembl; ENST00000345491.7; ENSP00000265372.5; ENSG00000095794.20. [Q03060-16]
DR Ensembl; ENST00000348787.6; ENSP00000345384.2; ENSG00000095794.20. [Q03060-30]
DR Ensembl; ENST00000354759.7; ENSP00000346804.3; ENSG00000095794.20. [Q03060-26]
DR Ensembl; ENST00000356917.9; ENSP00000349387.5; ENSG00000095794.20. [Q03060-9]
DR Ensembl; ENST00000361599.8; ENSP00000354593.4; ENSG00000095794.20. [Q03060-12]
DR Ensembl; ENST00000374726.7; ENSP00000363858.3; ENSG00000095794.20. [Q03060-25]
DR Ensembl; ENST00000374728.7; ENSP00000363860.3; ENSG00000095794.20. [Q03060-30]
DR Ensembl; ENST00000374734.7; ENSP00000363866.3; ENSG00000095794.20. [Q03060-32]
DR Ensembl; ENST00000395887.7; ENSP00000379225.3; ENSG00000095794.20. [Q03060-22]
DR Ensembl; ENST00000429130.7; ENSP00000393538.2; ENSG00000095794.20. [Q03060-5]
DR Ensembl; ENST00000439705.5; ENSP00000409220.2; ENSG00000095794.20. [Q03060-26]
DR Ensembl; ENST00000463314.5; ENSP00000418336.1; ENSG00000095794.20. [Q03060-28]
DR Ensembl; ENST00000468236.5; ENSP00000419810.1; ENSG00000095794.20. [Q03060-29]
DR Ensembl; ENST00000473940.5; ENSP00000420681.1; ENSG00000095794.20. [Q03060-8]
DR Ensembl; ENST00000474931.5; ENSP00000417562.1; ENSG00000095794.20. [Q03060-24]
DR Ensembl; ENST00000479070.5; ENSP00000420511.1; ENSG00000095794.20. [Q03060-15]
DR Ensembl; ENST00000487763.5; ENSP00000417807.1; ENSG00000095794.20. [Q03060-10]
DR Ensembl; ENST00000488328.5; ENSP00000417460.1; ENSG00000095794.20. [Q03060-11]
DR Ensembl; ENST00000488741.5; ENSP00000419075.1; ENSG00000095794.20. [Q03060-23]
DR Ensembl; ENST00000489321.5; ENSP00000419924.1; ENSG00000095794.20. [Q03060-25]
DR Ensembl; ENST00000490511.1; ENSP00000417327.1; ENSG00000095794.20. [Q03060-27]
DR Ensembl; ENST00000685392.1; ENSP00000509489.1; ENSG00000095794.20. [Q03060-31]
DR Ensembl; ENST00000686585.1; ENSP00000510546.1; ENSG00000095794.20. [Q03060-16]
DR GeneID; 1390; -.
DR KEGG; hsa:1390; -.
DR MANE-Select; ENST00000685392.1; ENSP00000509489.1; NM_183011.2; NP_898829.1. [Q03060-31]
DR UCSC; uc001ixx.4; human. [Q03060-5]
DR CTD; 1390; -.
DR DisGeNET; 1390; -.
DR GeneCards; CREM; -.
DR HGNC; HGNC:2352; CREM.
DR HPA; ENSG00000095794; Tissue enhanced (testis).
DR MIM; 123812; gene.
DR neXtProt; NX_Q03060; -.
DR OpenTargets; ENSG00000095794; -.
DR PharmGKB; PA26871; -.
DR VEuPathDB; HostDB:ENSG00000095794; -.
DR GeneTree; ENSGT00940000156952; -.
DR HOGENOM; CLU_142602_0_0_1; -.
DR InParanoid; Q03060; -.
DR OMA; MSKCSRK; -.
DR OrthoDB; 957343at2759; -.
DR PhylomeDB; Q03060; -.
DR TreeFam; TF106464; -.
DR PathwayCommons; Q03060; -.
DR Reactome; R-HSA-400253; Circadian Clock. [Q03060-6]
DR SignaLink; Q03060; -.
DR SIGNOR; Q03060; -.
DR BioGRID-ORCS; 1390; 15 hits in 1105 CRISPR screens.
DR ChiTaRS; CREM; human.
DR GeneWiki; CAMP_responsive_element_modulator; -.
DR GenomeRNAi; 1390; -.
DR Pharos; Q03060; Tbio.
DR PRO; PR:Q03060; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q03060; protein.
DR Bgee; ENSG00000095794; Expressed in left testis and 196 other tissues.
DR ExpressionAtlas; Q03060; baseline and differential.
DR Genevisible; Q03060; HS.
DR GO; GO:1990589; C:ATF4-CREB1 transcription factor complex; IBA:GO_Central.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0008140; F:cAMP response element binding protein binding; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IMP:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR003102; Coactivator_CBP_pKID.
DR InterPro; IPR001630; Leuzip_CREB.
DR PANTHER; PTHR45879; PTHR45879; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF02173; pKID; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS50953; KID; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative promoter usage; Alternative splicing;
KW Biological rhythms; Cytoplasm; Developmental protein; Differentiation;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW Spermatogenesis; Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..345
FT /note="cAMP-responsive element modulator"
FT /id="PRO_0000076607"
FT DOMAIN 88..147
FT /note="KID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00312"
FT DOMAIN 286..345
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 287..312
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 314..335
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT MOD_RES 102
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P27699"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 271
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18220336,
FT ECO:0007744|PubMed:18669648"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18220336"
FT MOD_RES 277
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18220336,
FT ECO:0007744|PubMed:18669648"
FT VAR_SEQ 1..244
FT /note="MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGS
FT PAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKR
FT REILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYI
FT AIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQV
FT VVQDEETELAPSHMA -> MNRTQELSGQLS (in isoform 21 and isoform
FT 24)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_059697"
FT VAR_SEQ 1..244
FT /note="MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGS
FT PAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKR
FT REILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYI
FT AIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQV
FT VVQDEETELAPSHMA -> MAVTGDDT (in isoform 7 and isoform 9)"
FT /evidence="ECO:0000303|PubMed:8206879"
FT /id="VSP_059698"
FT VAR_SEQ 1..242
FT /note="Missing (in isoform 20)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_059699"
FT VAR_SEQ 1..232
FT /note="MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGS
FT PAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKR
FT REILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYI
FT AIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQV
FT VVQ -> MNRTQELSGQLS (in isoform 26)"
FT /id="VSP_059700"
FT VAR_SEQ 1..232
FT /note="MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGS
FT PAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKR
FT REILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYI
FT AIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQV
FT VVQ -> MAVTGDDT (in isoform 6 and isoform 8)"
FT /evidence="ECO:0000303|PubMed:8206879,
FT ECO:0000303|PubMed:8622971, ECO:0000303|Ref.4"
FT /id="VSP_059701"
FT VAR_SEQ 1..195
FT /note="Missing (in isoform 25)"
FT /id="VSP_059702"
FT VAR_SEQ 1..89
FT /note="MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGS
FT PAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQ -> MWWHQHNLCFRRPIEEDY
FT SSGDVEEK (in isoform 10, isoform 11 and isoform 19)"
FT /evidence="ECO:0000303|PubMed:12397208"
FT /id="VSP_059703"
FT VAR_SEQ 1..89
FT /note="MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGS
FT PAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQ -> M (in isoform 5
FT and isoform 12)"
FT /id="VSP_059704"
FT VAR_SEQ 1
FT /note="M -> MSKCARKKYIKTNPRQM (in isoform 2, isoform 3,
FT isoform 4, isoform 13, isoform 14, isoform 15, isoform 16,
FT isoform 17, isoform 18, isoform 23, isoform 28 and isoform
FT 29)"
FT /evidence="ECO:0000303|PubMed:1461747,
FT ECO:0000303|PubMed:7916662, ECO:0000303|PubMed:8206879"
FT /id="VSP_059705"
FT VAR_SEQ 42..232
FT /note="Missing (in isoform 16)"
FT /id="VSP_059706"
FT VAR_SEQ 42..169
FT /note="Missing (in isoform 15)"
FT /id="VSP_059707"
FT VAR_SEQ 42..90
FT /note="Missing (in isoform 4, isoform 13, isoform 14,
FT isoform 22, isoform 23, isoform 27, isoform 28 and isoform
FT 29)"
FT /evidence="ECO:0000303|PubMed:1461747,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8206879"
FT /id="VSP_059708"
FT VAR_SEQ 170..245
FT /note="IAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQ
FT FFVPGSQVVVQDEETELAPSHMAA -> T (in isoform 4, isoform 27 and
FT isoform 29)"
FT /id="VSP_059709"
FT VAR_SEQ 170..244
FT /note="Missing (in isoform 17 and isoform 18)"
FT /id="VSP_059710"
FT VAR_SEQ 170..233
FT /note="IAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQ
FT FFVPGSQVVVQD -> N (in isoform 23)"
FT /evidence="ECO:0000303|PubMed:8206879"
FT /id="VSP_059711"
FT VAR_SEQ 170..232
FT /note="Missing (in isoform 11 and isoform 12)"
FT /evidence="ECO:0000303|PubMed:12397208"
FT /id="VSP_059712"
FT VAR_SEQ 170..186
FT /note="IAIAQGGTIQISNPGSD -> SMYAAIRYDTVLALSLL (in isoform
FT 22)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_059713"
FT VAR_SEQ 187..345
FT /note="Missing (in isoform 22)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_059714"
FT VAR_SEQ 233..244
FT /note="Missing (in isoform 2, isoform 3, isoform 5, isoform
FT 10, isoform 14, isoform 15, isoform 25 and isoform 28)"
FT /evidence="ECO:0000303|PubMed:12397208,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:7916662, ECO:0000303|Ref.5"
FT /id="VSP_059715"
FT VAR_SEQ 245
FT /note="A -> T (in isoform 12 and isoform 11)"
FT /evidence="ECO:0000303|PubMed:1461747"
FT /id="VSP_059716"
FT VAR_SEQ 301..345
FT /note="KECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY -> REC
FT RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKVE (in isoform 3,
FT isoform 6, isoform 7, isoform 18, isoform 20, isoform 21,
FT isoform 23, isoform 28 and isoform 29)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:7916662, ECO:0000303|PubMed:8206879,
FT ECO:0000303|Ref.4"
FT /id="VSP_059717"
FT VARIANT 254
FT /note="Q -> R (in dbSNP:rs1804604)"
FT /evidence="ECO:0000269|PubMed:8622971"
FT /id="VAR_055561"
FT CONFLICT 33
FT /note="N -> I (in Ref. 11; AAC60616/AAC60617)"
FT /evidence="ECO:0000305"
FT CONFLICT 39
FT /note="A -> R (in Ref. 1; CAA78858)"
FT /evidence="ECO:0000305"
FT CONFLICT 41..45
FT /note="VSVAG -> CSELR (in Ref. 11; AAC60616/AAC60617)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="H -> R (in Ref. 2; BAA03562 and 4; BAA03564/
FT BAA03565/BAA03566/BAA03567)"
FT /evidence="ECO:0000305"
FT CONFLICT Q03060-8:7
FT /note="D -> E (in Ref. 4; AAC19383)"
FT /evidence="ECO:0000305"
FT CONFLICT Q03060-8:112
FT /note="K -> R (in Ref. 4; AAC19383)"
FT /evidence="ECO:0000305"
FT CONFLICT Q03060-10:7
FT /note="D -> E (in Ref. 3; AAB03751)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 37006 MW; 4DDEE62904CDD0E6 CRC64;
MTMETVESQH DGSITASLTE SKSAHVQTQT GQNSIPALAQ VSVAGSGTRR GSPAVTLVQL
PSGQTIHVQG VIQTPQPWVI QSSEIHTVQV AAIAETDESA ESEGVIDSHK RREILSRRPS
YRKILNELSS DVPGVPKIEE ERSEEEGTPP SIATMAVPTS IYQTSTGQYI AIAQGGTIQI
SNPGSDGVQG LQALTMTNSG APPPGATIVQ YAAQSADGTQ QFFVPGSQVV VQDEETELAP
SHMAAATGDM PTYQIRAPTA ALPQGVVMAA SPGSLHSPQQ LAEEATRKRE LRLMKNREAA
KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS PKTDY
