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CREM_MOUSE
ID   CREM_MOUSE              Reviewed;         357 AA.
AC   P27699; P27698; Q5XTP8; Q5XTP9; Q5XTQ0; Q5XTQ1; Q5XTQ2; Q5XTQ3; Q99JF1;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 179.
DE   RecName: Full=cAMP-responsive element modulator;
DE   AltName: Full=Inducible cAMP early repressor;
DE            Short=ICER;
GN   Name=Crem;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11), ALTERNATIVE PROMOTER USAGE,
RP   SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=8252624; DOI=10.1016/0092-8674(93)90532-u;
RA   Molina C.A., Foulkes N.S., Lalli E., Sassone-Corsi P.;
RT   "Inducibility and negative autoregulation of CREM: an alternative promoter
RT   directs the expression of ICER, an early response repressor.";
RL   Cell 75:875-886(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-357 (ISOFORMS 2; 3 AND 4).
RX   PubMed=1847666; DOI=10.1016/0092-8674(91)90503-q;
RA   Foulkes N.S., Borrelli E., Sassone-Corsi P.;
RT   "CREM gene: use of alternative DNA-binding domains generates multiple
RT   antagonists of cAMP-induced transcription.";
RL   Cell 64:739-749(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 11-357 (ISOFORMS 5; 6; 7; 8; 9 AND 10).
RC   TISSUE=Osteoblast;
RX   PubMed=16059773; DOI=10.1007/s00223-005-0003-1;
RA   Liu F., Huang Y.-F., Kream B.E.;
RT   "Identification of novel cAMP responsive element modulator (CREM) isoforms
RT   expressed by osteoblasts.";
RL   Calcif. Tissue Int. 77:91-95(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 17-357 (ISOFORM 1).
RX   PubMed=1370576; DOI=10.1038/355080a0;
RA   Foulkes N.S., Mellstroem B., Benusiglio E., Sassone-Corsi P.;
RT   "Developmental switch of CREM function during spermatogenesis: from
RT   antagonist to activator.";
RL   Nature 355:80-84(1992).
RN   [6]
RP   INTERACTION WITH FHL5.
RX   PubMed=10086359; DOI=10.1038/18237;
RA   Fimia G.M., De Cesare D., Sassone-Corsi P.;
RT   "CBP-independent activation of CREM and CREB by the LIM-only protein ACT.";
RL   Nature 398:165-169(1999).
RN   [7]
RP   FUNCTION, AND INTERACTION WITH CREB3L4.
RX   PubMed=16595651; DOI=10.1074/jbc.m602051200;
RA   Nagamori I., Yomogida K., Adams P.D., Sassone-Corsi P., Nojima H.;
RT   "Transcription factors, cAMP-responsive element modulator (CREM) and
RT   Tisp40, act in concert in postmeiotic transcriptional regulation.";
RL   J. Biol. Chem. 281:15073-15081(2006).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284; SER-287 AND SER-290, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [9]
RP   FUNCTION (ISOFORM 11), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION,
RP   AND INDUCTION.
RX   PubMed=23443664; DOI=10.1074/jbc.m112.445692;
RA   Zmrzljak U.P., Korencic A., Kosir R., Golicnik M., Sassone-Corsi P.,
RA   Rozman D.;
RT   "Inducible cAMP early repressor regulates the Period 1 gene of the hepatic
RT   and adrenal clocks.";
RL   J. Biol. Chem. 288:10318-10327(2013).
RN   [10]
RP   INTERACTION WITH TSSK4, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-116, AND
RP   MUTAGENESIS OF SER-116.
RX   PubMed=26940607; DOI=10.1080/09168451.2016.1146067;
RA   Fu G., Wei Y., Wang X., Yu L.;
RT   "Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate
RT   Crem at Ser-117.";
RL   Biosci. Biotechnol. Biochem. 80:1088-1094(2016).
CC   -!- FUNCTION: Transcriptional regulator that binds the cAMP response
CC       element (CRE), a sequence present in many viral and cellular promoters.
CC       Isoforms are either transcriptional activators or repressors. Isoform
CC       2, isoform 3 and isoform 4 are repressors, while isoform 1 is an
CC       activator. Plays a role in spermatogenesis and is involved in spermatid
CC       maturation. Binding of isoform 1 (activator) to CRE is increased by
CC       CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE
CC       and may recruit HIRA to CRE to regulate histone exchange
CC       (PubMed:16595651). {ECO:0000269|PubMed:16595651}.
CC   -!- FUNCTION: [Isoform 11]: Plays a role in the regulation of the circadian
CC       clock: acts as a transcriptional repressor of the core circadian
CC       component PER1 by directly binding to cAMP response elements in its
CC       promoter. {ECO:0000269|PubMed:16595651, ECO:0000269|PubMed:23443664}.
CC   -!- SUBUNIT: Binds DNA as a dimer (By similarity). Interacts with CDC34 (By
CC       similarity). Interacts with FHL5 (PubMed:10086359). May interact with
CC       TSSK4 (PubMed:26940607). Isoform 1 forms a heterodimer with CREB3L4
CC       (PubMed:16595651). {ECO:0000250|UniProtKB:Q03060,
CC       ECO:0000269|PubMed:10086359, ECO:0000269|PubMed:16595651,
CC       ECO:0000269|PubMed:26940607}.
CC   -!- INTERACTION:
CC       P27699; O09106: Hdac1; NbExp=3; IntAct=EBI-8744406, EBI-301912;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23443664,
CC       ECO:0000269|PubMed:8252624}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 11]: Cytoplasm. Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage, Alternative splicing; Named isoforms=11;
CC       Name=1; Synonyms=CREM-BCEFGgammaHIbeta, Tau;
CC         IsoId=P27699-1; Sequence=Displayed;
CC       Name=2; Synonyms=Alpha;
CC         IsoId=P27699-2; Sequence=VSP_000602, VSP_000603, VSP_000604,
CC                                  VSP_000607;
CC       Name=3; Synonyms=Beta;
CC         IsoId=P27699-3; Sequence=VSP_000602, VSP_000603, VSP_000604;
CC       Name=4; Synonyms=Gamma;
CC         IsoId=P27699-4; Sequence=VSP_000602, VSP_000605, VSP_000606;
CC       Name=5; Synonyms=Tau Alpha Gamma;
CC         IsoId=P27699-5; Sequence=VSP_038016, VSP_000607;
CC       Name=6; Synonyms=Tau 2 Alpha;
CC         IsoId=P27699-6; Sequence=VSP_000602, VSP_000607;
CC       Name=7; Synonyms=Tau 1 Alpha;
CC         IsoId=P27699-7; Sequence=VSP_000603, VSP_000604, VSP_000607;
CC       Name=8; Synonyms=Tau 1 Alpha Gamma;
CC         IsoId=P27699-8; Sequence=VSP_000605, VSP_000606, VSP_000607;
CC       Name=9; Synonyms=Tau 1 Gamma;
CC         IsoId=P27699-9; Sequence=VSP_000605, VSP_000606;
CC       Name=10; Synonyms=Alpha Gamma;
CC         IsoId=P27699-10; Sequence=VSP_000602, VSP_000605, VSP_000606,
CC                                   VSP_000607;
CC       Name=11; Synonyms=Icer Gamma;
CC         IsoId=P27699-11; Sequence=VSP_055987, VSP_000607;
CC   -!- TISSUE SPECIFICITY: Expressed in the testis.
CC       {ECO:0000269|PubMed:26940607}.
CC   -!- DEVELOPMENTAL STAGE: In premeiotic germ cells, expressed at low amounts
CC       in the antagonist form. Subsequently, during spermatogenesis, isoform 1
CC       (activator) is generated exclusively and in extremely high amounts.
CC   -!- INDUCTION: Isoform 11 is expressed in a circadian manner in the adrenal
CC       gland with an expression peak at ZT20 (at protein level). It is induced
CC       by cAMP in an immediate-early fashion and can repress its own
CC       production via a negative autoregulatory mechanism.
CC       {ECO:0000269|PubMed:23443664, ECO:0000269|PubMed:8252624}.
CC   -!- PTM: Stimulated by phosphorylation (By similarity). Phosphorylated on
CC       Ser-116 by TSSK4 in vitro. {ECO:0000250|UniProtKB:Q01147,
CC       ECO:0000269|PubMed:26940607}.
CC   -!- PTM: Ubiquitinated by CDC34 and RAD6B in order to be degraded by the
CC       proteasome. {ECO:0000250}.
CC   -!- MISCELLANEOUS: CREM-null deficient mice display male infertility: while
CC       spermatogonia differentiate normally into round spermatids, all the
CC       elongating spermatids are eliminated by apoptosis during
CC       spermiogenesis.
CC   -!- MISCELLANEOUS: [Isoform 11]: Produced by alternative promoter usage.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA17495.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAA17496.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAA17497.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAV28551.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAV28552.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAV28553.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAV28554.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAV28555.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAV28556.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ311667; CAC34846.1; -; mRNA.
DR   EMBL; AC117589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M60285; AAA17495.1; ALT_INIT; mRNA.
DR   EMBL; M60285; AAA17496.1; ALT_INIT; mRNA.
DR   EMBL; M60285; AAA17497.1; ALT_INIT; mRNA.
DR   EMBL; AY738715; AAV28551.1; ALT_INIT; mRNA.
DR   EMBL; AY738716; AAV28552.1; ALT_INIT; mRNA.
DR   EMBL; AY738717; AAV28553.1; ALT_INIT; mRNA.
DR   EMBL; AY738718; AAV28554.1; ALT_INIT; mRNA.
DR   EMBL; AY738719; AAV28555.1; ALT_INIT; mRNA.
DR   EMBL; AY738721; AAV28556.1; ALT_INIT; mRNA.
DR   CCDS; CCDS29031.2; -. [P27699-2]
DR   CCDS; CCDS50214.1; -. [P27699-7]
DR   CCDS; CCDS50215.1; -. [P27699-1]
DR   CCDS; CCDS70862.1; -. [P27699-6]
DR   CCDS; CCDS70863.1; -. [P27699-8]
DR   CCDS; CCDS70864.1; -. [P27699-5]
DR   PIR; A37944; A37944.
DR   PIR; B37944; B37944.
DR   PIR; C37944; C37944.
DR   PIR; S20827; S20827.
DR   RefSeq; NP_001104320.1; NM_001110850.2. [P27699-10]
DR   RefSeq; NP_001104324.2; NM_001110854.1.
DR   RefSeq; NP_001104325.2; NM_001110855.1.
DR   RefSeq; NP_001104326.1; NM_001110856.2. [P27699-7]
DR   RefSeq; NP_001104327.1; NM_001110857.2. [P27699-3]
DR   RefSeq; NP_001104328.1; NM_001110858.2. [P27699-4]
DR   RefSeq; NP_001104329.1; NM_001110859.2. [P27699-1]
DR   RefSeq; NP_001258432.1; NM_001271503.1. [P27699-9]
DR   RefSeq; NP_001258433.1; NM_001271504.1. [P27699-8]
DR   RefSeq; NP_001258434.1; NM_001271505.1. [P27699-6]
DR   RefSeq; NP_001258435.1; NM_001271506.1. [P27699-5]
DR   RefSeq; NP_038526.2; NM_013498.3. [P27699-2]
DR   RefSeq; XP_006525618.1; XM_006525555.3. [P27699-1]
DR   RefSeq; XP_006525619.1; XM_006525556.3. [P27699-5]
DR   RefSeq; XP_006525624.1; XM_006525561.3. [P27699-6]
DR   RefSeq; XP_006525628.1; XM_006525565.3. [P27699-7]
DR   RefSeq; XP_006525630.1; XM_006525567.3. [P27699-8]
DR   RefSeq; XP_006525631.1; XM_006525568.3. [P27699-9]
DR   RefSeq; XP_006525636.1; XM_006525573.3. [P27699-2]
DR   RefSeq; XP_006525637.1; XM_006525574.3. [P27699-3]
DR   RefSeq; XP_006525638.1; XM_006525575.3. [P27699-10]
DR   RefSeq; XP_006525639.1; XM_006525576.3. [P27699-4]
DR   AlphaFoldDB; P27699; -.
DR   SMR; P27699; -.
DR   BioGRID; 198877; 6.
DR   IntAct; P27699; 3.
DR   MINT; P27699; -.
DR   STRING; 10090.ENSMUSP00000121233; -.
DR   iPTMnet; P27699; -.
DR   PhosphoSitePlus; P27699; -.
DR   MaxQB; P27699; -.
DR   PaxDb; P27699; -.
DR   PRIDE; P27699; -.
DR   ProteomicsDB; 284124; -. [P27699-1]
DR   ProteomicsDB; 284125; -. [P27699-2]
DR   ProteomicsDB; 284126; -. [P27699-3]
DR   ProteomicsDB; 284127; -. [P27699-4]
DR   ProteomicsDB; 284128; -. [P27699-5]
DR   ProteomicsDB; 284129; -. [P27699-6]
DR   ProteomicsDB; 284130; -. [P27699-7]
DR   ProteomicsDB; 284131; -. [P27699-8]
DR   ProteomicsDB; 284132; -. [P27699-9]
DR   ProteomicsDB; 284133; -. [P27699-10]
DR   ProteomicsDB; 284134; -. [P27699-11]
DR   Antibodypedia; 4333; 434 antibodies from 36 providers.
DR   DNASU; 12916; -.
DR   Ensembl; ENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889. [P27699-5]
DR   Ensembl; ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889. [P27699-6]
DR   Ensembl; ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889. [P27699-1]
DR   Ensembl; ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889. [P27699-2]
DR   Ensembl; ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889. [P27699-8]
DR   Ensembl; ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889. [P27699-7]
DR   GeneID; 12916; -.
DR   KEGG; mmu:12916; -.
DR   UCSC; uc008dxp.2; mouse. [P27699-8]
DR   UCSC; uc008dxq.2; mouse. [P27699-9]
DR   UCSC; uc008dxr.2; mouse. [P27699-5]
DR   UCSC; uc008dxs.2; mouse. [P27699-6]
DR   UCSC; uc033hfn.1; mouse. [P27699-1]
DR   UCSC; uc033hfo.1; mouse. [P27699-4]
DR   UCSC; uc033hfp.1; mouse. [P27699-7]
DR   UCSC; uc033hfq.1; mouse. [P27699-2]
DR   UCSC; uc033hfr.1; mouse. [P27699-3]
DR   UCSC; uc033hfs.1; mouse. [P27699-10]
DR   CTD; 1390; -.
DR   MGI; MGI:88495; Crem.
DR   VEuPathDB; HostDB:ENSMUSG00000063889; -.
DR   eggNOG; KOG3584; Eukaryota.
DR   GeneTree; ENSGT00940000156952; -.
DR   InParanoid; P27699; -.
DR   OrthoDB; 957343at2759; -.
DR   PhylomeDB; P27699; -.
DR   TreeFam; TF106464; -.
DR   BioGRID-ORCS; 12916; 1 hit in 69 CRISPR screens.
DR   ChiTaRS; Crem; mouse.
DR   PRO; PR:P27699; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; P27699; protein.
DR   Bgee; ENSMUSG00000063889; Expressed in spermatid and 229 other tissues.
DR   ExpressionAtlas; P27699; baseline and differential.
DR   Genevisible; P27699; MM.
DR   GO; GO:1990589; C:ATF4-CREB1 transcription factor complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0032922; P:circadian regulation of gene expression; IMP:UniProtKB.
DR   GO; GO:0007623; P:circadian rhythm; IEP:UniProtKB.
DR   GO; GO:0006687; P:glycosphingolipid metabolic process; IMP:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR   GO; GO:0051591; P:response to cAMP; IDA:UniProtKB.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR003102; Coactivator_CBP_pKID.
DR   InterPro; IPR001630; Leuzip_CREB.
DR   PANTHER; PTHR45879; PTHR45879; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   Pfam; PF02173; pKID; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
DR   PROSITE; PS50953; KID; 1.
PE   1: Evidence at protein level;
KW   Activator; Alternative promoter usage; Alternative splicing;
KW   Biological rhythms; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..357
FT                   /note="cAMP-responsive element modulator"
FT                   /id="PRO_0000076608"
FT   DOMAIN          101..160
FT                   /note="KID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00312"
FT   DOMAIN          299..357
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          20..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..325
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          327..348
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:26940607"
FT   MOD_RES         142
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q03060"
FT   MOD_RES         284
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         287
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         290
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   VAR_SEQ         1..245
FT                   /note="MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHMQTGQISVPTL
FT                   AQVSVAGSGTGRGSPAVTLVQLPSGQTVQVQGVIQTPHPSVIQSPQIQTVQVATIAETD
FT                   DSADSEVIDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMAV
FT                   PTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSA
FT                   DGTQQFFVPGSQVVVQ -> MAVTGDET (in isoform 11)"
FT                   /evidence="ECO:0000303|PubMed:8252624"
FT                   /id="VSP_055987"
FT   VAR_SEQ         55..103
FT                   /note="Missing (in isoform 2, isoform 3, isoform 4, isoform
FT                   6 and isoform 10)"
FT                   /evidence="ECO:0000303|PubMed:16059773,
FT                   ECO:0000303|PubMed:1847666"
FT                   /id="VSP_000602"
FT   VAR_SEQ         183..257
FT                   /note="Missing (in isoform 4, isoform 8, isoform 9 and
FT                   isoform 10)"
FT                   /evidence="ECO:0000303|PubMed:16059773,
FT                   ECO:0000303|PubMed:1847666"
FT                   /id="VSP_000605"
FT   VAR_SEQ         183..245
FT                   /note="Missing (in isoform 2, isoform 3 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:16059773,
FT                   ECO:0000303|PubMed:1847666"
FT                   /id="VSP_000603"
FT   VAR_SEQ         246..257
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:16059773"
FT                   /id="VSP_038016"
FT   VAR_SEQ         246
FT                   /note="D -> N (in isoform 2, isoform 3 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:16059773,
FT                   ECO:0000303|PubMed:1847666"
FT                   /id="VSP_000604"
FT   VAR_SEQ         258
FT                   /note="A -> T (in isoform 4, isoform 8, isoform 9 and
FT                   isoform 10)"
FT                   /evidence="ECO:0000303|PubMed:16059773,
FT                   ECO:0000303|PubMed:1847666"
FT                   /id="VSP_000606"
FT   VAR_SEQ         314..357
FT                   /note="KECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD -> RECR
FT                   RKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKAE (in isoform 2,
FT                   isoform 5, isoform 6, isoform 7, isoform 8, isoform 10 and
FT                   isoform 11)"
FT                   /evidence="ECO:0000303|PubMed:16059773,
FT                   ECO:0000303|PubMed:1847666, ECO:0000303|PubMed:8252624"
FT                   /id="VSP_000607"
FT   MUTAGEN         116
FT                   /note="S->M: Loss of in vitro phosphorylation by TSSK4."
FT                   /evidence="ECO:0000269|PubMed:26940607"
SQ   SEQUENCE   357 AA;  38516 MW;  0B387B7247113088 CRC64;
     MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVSVAGS
     GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ TVQVATIAET DDSADSEVID
     SHKRREILSR RPSYRKILNE LSSDVPGIPK IEEEKSEEEG TPPNIATMAV PTSIYQTSTG
     QYIAIAQGGT IQISNPGSDG VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS
     QVVVQDEETD LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR
     KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD ICSPKTD
 
 
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