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CREN7_SACS2
ID   CREN7_SACS2             Reviewed;          60 AA.
AC   Q97ZE3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Chromatin protein Cren7;
GN   Name=creN7; OrderedLocusNames=SSO6901;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [2]
RP   FUNCTION IN DNA-BINDING, SUBUNIT, AND STRUCTURE BY NMR.
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=18096617; DOI=10.1093/nar/gkm1128;
RA   Guo L., Feng Y., Zhang Z., Yao H., Luo Y., Wang J., Huang L.;
RT   "Biochemical and structural characterization of Cren7, a novel chromatin
RT   protein conserved among Crenarchaea.";
RL   Nucleic Acids Res. 36:1129-1137(2008).
CC   -!- FUNCTION: A highly abundant probable chromatin protein, it binds
CC       double-strand DNA without sequence specificity; there is approximately
CC       1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils,
CC       increases DNA stability against thermal denaturation. Binding does not
CC       require protein methylation. Binds single-strand DNA weakly.
CC       {ECO:0000269|PubMed:18096617}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:18096617}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Methylated at multiple sites, to varying extents. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Cren7 family. {ECO:0000305}.
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DR   EMBL; AE006641; AAK41249.1; -; Genomic_DNA.
DR   PIR; B90249; B90249.
DR   RefSeq; WP_009992425.1; NC_002754.1.
DR   PDB; 2JTM; NMR; -; A=1-60.
DR   PDB; 3KXT; X-ray; 1.60 A; A=6-60.
DR   PDB; 3LWH; X-ray; 1.90 A; A=1-60.
DR   PDB; 3LWI; X-ray; 2.30 A; A/B=1-60.
DR   PDB; 4R55; X-ray; 1.80 A; A=1-60.
DR   PDB; 4R56; X-ray; 2.30 A; A/B=1-60.
DR   PDB; 5K07; X-ray; 2.00 A; A=1-60.
DR   PDB; 5K17; X-ray; 2.10 A; A/B=1-60.
DR   PDB; 5WVW; X-ray; 1.80 A; A/B=1-60.
DR   PDB; 5WVY; X-ray; 2.00 A; A/B=1-60.
DR   PDB; 5WVZ; X-ray; 2.30 A; A/B=1-60.
DR   PDB; 5WWC; X-ray; 1.90 A; A/B=1-60.
DR   PDB; 6A2H; X-ray; 2.30 A; A=1-60.
DR   PDB; 6A2I; X-ray; 2.40 A; A/B=1-60.
DR   PDBsum; 2JTM; -.
DR   PDBsum; 3KXT; -.
DR   PDBsum; 3LWH; -.
DR   PDBsum; 3LWI; -.
DR   PDBsum; 4R55; -.
DR   PDBsum; 4R56; -.
DR   PDBsum; 5K07; -.
DR   PDBsum; 5K17; -.
DR   PDBsum; 5WVW; -.
DR   PDBsum; 5WVY; -.
DR   PDBsum; 5WVZ; -.
DR   PDBsum; 5WWC; -.
DR   PDBsum; 6A2H; -.
DR   PDBsum; 6A2I; -.
DR   AlphaFoldDB; Q97ZE3; -.
DR   SMR; Q97ZE3; -.
DR   STRING; 273057.SSO6901; -.
DR   EnsemblBacteria; AAK41249; AAK41249; SSO6901.
DR   GeneID; 44129907; -.
DR   KEGG; sso:SSO6901; -.
DR   PATRIC; fig|273057.12.peg.974; -.
DR   eggNOG; arCOG04114; Archaea.
DR   HOGENOM; CLU_2911298_0_0_2; -.
DR   OMA; LAPEKAW; -.
DR   EvolutionaryTrace; Q97ZE3; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.610; -; 1.
DR   HAMAP; MF_01387; Chromatin_Cren7; 1.
DR   InterPro; IPR038647; Cren7_sf.
DR   InterPro; IPR020906; dsDNA-bd_Cren7.
DR   Pfam; PF11520; Cren7; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA-binding; Methylation; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..60
FT                   /note="Chromatin protein Cren7"
FT                   /id="PRO_0000345178"
FT   STRAND          8..11
FT                   /evidence="ECO:0007829|PDB:3KXT"
FT   STRAND          17..20
FT                   /evidence="ECO:0007829|PDB:3KXT"
FT   STRAND          23..28
FT                   /evidence="ECO:0007829|PDB:3KXT"
FT   STRAND          36..42
FT                   /evidence="ECO:0007829|PDB:3KXT"
FT   TURN            44..46
FT                   /evidence="ECO:0007829|PDB:3KXT"
FT   STRAND          49..53
FT                   /evidence="ECO:0007829|PDB:3KXT"
SQ   SEQUENCE   60 AA;  6663 MW;  665BC5BE3FA53C8D CRC64;
     MSSGKKPVKV KTPAGKEAEL VPEKVWALAP KGRKGVKIGL FKDPETGKYF RHKLPDDYPI
 
 
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