CRERF_MOUSE
ID CRERF_MOUSE Reviewed; 640 AA.
AC Q8CDG5; B8JJI1; Q14DI2; Q8C8N7; Q9CTQ7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=CREB3 regulatory factor;
DE AltName: Full=Luman recruitment factor;
DE Short=LRF;
GN Name=Crebrf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=18391022; DOI=10.1128/mcb.01439-07;
RA Audas T.E., Li Y., Liang G., Lu R.;
RT "A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation
RT of the unfolded protein response.";
RL Mol. Cell. Biol. 28:3952-3966(2008).
CC -!- FUNCTION: Acts as a negative regulator of the endoplasmic reticulum
CC stress response or unfolded protein response (UPR). Represses the
CC transcriptional activity of CREB3 during the UPR. Recruits CREB3 into
CC nuclear foci (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via leucine-zipper domain) with CREB3 (via leucine-
CC zipper domain); the interaction promotes CREB3 degradation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with
CC CREB3 in nuclear foci. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in intestin, testis, heart and
CC kidney, weakly in brain adipose, colon, liver, lung and skeletal.
CC {ECO:0000269|PubMed:18391022}.
CC -!- PTM: Probably degraded by the proteasome. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bZIP family. CREBRF subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK020796; BAB32214.1; -; mRNA.
DR EMBL; AK030092; BAC26779.1; -; mRNA.
DR EMBL; AK044760; BAC32070.1; -; mRNA.
DR EMBL; CT025550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113191; AAI13192.1; -; mRNA.
DR EMBL; BC113192; AAI13193.1; -; mRNA.
DR CCDS; CCDS37516.1; -.
DR RefSeq; NP_084146.1; NM_029870.2.
DR RefSeq; XP_006525177.1; XM_006525114.2.
DR RefSeq; XP_011245019.2; XM_011246717.2.
DR RefSeq; XP_017173212.1; XM_017317723.1.
DR AlphaFoldDB; Q8CDG5; -.
DR STRING; 10090.ENSMUSP00000059102; -.
DR iPTMnet; Q8CDG5; -.
DR PhosphoSitePlus; Q8CDG5; -.
DR EPD; Q8CDG5; -.
DR MaxQB; Q8CDG5; -.
DR PaxDb; Q8CDG5; -.
DR PeptideAtlas; Q8CDG5; -.
DR PRIDE; Q8CDG5; -.
DR ProteomicsDB; 278034; -.
DR Antibodypedia; 28933; 28 antibodies from 12 providers.
DR DNASU; 77128; -.
DR Ensembl; ENSMUST00000062519; ENSMUSP00000059102; ENSMUSG00000048249.
DR GeneID; 77128; -.
DR KEGG; mmu:77128; -.
DR UCSC; uc008bej.1; mouse.
DR CTD; 153222; -.
DR MGI; MGI:1924378; Crebrf.
DR VEuPathDB; HostDB:ENSMUSG00000048249; -.
DR eggNOG; ENOG502QTAK; Eukaryota.
DR GeneTree; ENSGT00390000007125; -.
DR HOGENOM; CLU_031769_0_0_1; -.
DR InParanoid; Q8CDG5; -.
DR OMA; ECETVHS; -.
DR OrthoDB; 252839at2759; -.
DR PhylomeDB; Q8CDG5; -.
DR TreeFam; TF330810; -.
DR Reactome; R-MMU-8874211; CREB3 factors activate genes.
DR BioGRID-ORCS; 77128; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Crebrf; mouse.
DR PRO; PR:Q8CDG5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8CDG5; protein.
DR Bgee; ENSMUSG00000048249; Expressed in vestibular membrane of cochlear duct and 245 other tissues.
DR ExpressionAtlas; Q8CDG5; baseline and differential.
DR Genevisible; Q8CDG5; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016604; C:nuclear body; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0042711; P:maternal behavior; IMP:MGI.
DR GO; GO:1900102; P:negative regulation of endoplasmic reticulum unfolded protein response; ISS:UniProtKB.
DR GO; GO:1900170; P:negative regulation of glucocorticoid mediated signaling pathway; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0032388; P:positive regulation of intracellular transport; ISS:UniProtKB.
DR GO; GO:1902213; P:positive regulation of prolactin signaling pathway; IMP:MGI.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; ISS:UniProtKB.
DR GO; GO:0051222; P:positive regulation of protein transport; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR039165; CREBRF.
DR PANTHER; PTHR21552; PTHR21552; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation; Transport; Unfolded protein response.
FT CHAIN 1..640
FT /note="CREB3 regulatory factor"
FT /id="PRO_0000299307"
FT DOMAIN 522..585
FT /note="bZIP"
FT REGION 308..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..533
FT /note="Basic motif"
FT /evidence="ECO:0000250"
FT REGION 534..541
FT /note="Leucine-zipper"
FT /evidence="ECO:0000250"
FT COMPBIAS 308..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..406
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="F -> V (in Ref. 3; AAI13192)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 640 AA; 72598 MW; FE02C532FA34E1DE CRC64;
MPQPSVSGMD PPFGDAFRSH TFSEQTLMST DLLANSSDPD FMYELDREMN YQQNPRDNFL
SLEDCKDIEN LETFTDVLDN EDALTSNWEQ WDTYCEDLTK YTKLTSCDIW GTKEVDYLGL
DDFSSPYQDE EVISKTPTLA QLNSEDSQSV SDSLYYPDSL FSVKQNPLPP SSFPSKKITN
RAAAPVCSSK TLQAEVPSSD CVQKASKPTS STQIMVKTNM YHNEKVNFHV ECKDYVKKAK
VKINPVQQGR PLLSQVHIDA AKENTCYCGA VAKRQERRGV EPHQGRGTPA LPFKETQELL
LSPLTQDSPG LVATAESGSL SASTSVSDSS QKKEEHNYSL FVSDNMREQP TKYSPEDDED
DEDEFDDEDH DEGFGSEHEL SENEEEEEEE EDYEDDRDDD ISDTFSEPGY ENDSVEDLKE
MTSISSRKRG KRRYFWEYSE QLTPSQQERI LRPSEWNRDT LPSNMYQKNG LHHGKYAVKK
SRRTDVEDLT PNPKKLLQIG NELRKLNKVI SDLTPVSELP LTARPRSRKE KNKLASRACR
LKKKAQYEAN KVKLWGLNTE YDNLLFVINS IKQDIVNRVQ NPREEREPSM GQKLEILIKD
TLGLPVAGQT SEFVNQVLGK TAEGNPTGGL VGLRIPASKV
