ID   CREST_XENLA             Reviewed;         403 AA.
AC   Q6DDK1;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Calcium-responsive transactivator;
DE   AltName: Full=ss18-like protein 1;
GN   Name=ss18l1; Synonyms=crest;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator which may be required for calcium-
CC       dependent dendritic growth and branching in cortical neurons.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       bodies. {ECO:0000250}.
CC   -!- DOMAIN: The MFD (multi-functional domain) domain is involved in
CC       transcription transactivation, nuclear body targeting and dimerization.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SS18 family. {ECO:0000305}.
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DR   EMBL; BC077557; AAH77557.1; -; mRNA.
DR   RefSeq; NP_001087101.1; NM_001093632.1.
DR   AlphaFoldDB; Q6DDK1; -.
DR   SMR; Q6DDK1; -.
DR   DNASU; 446990; -.
DR   GeneID; 446990; -.
DR   KEGG; xla:446990; -.
DR   CTD; 446990; -.
DR   Xenbase; XB-GENE-993778; ss18l1.S.
DR   OMA; XPAQGAP; -.
DR   OrthoDB; 1442230at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 446990; Expressed in brain and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   InterPro; IPR044779; SS18.
DR   InterPro; IPR007726; SS18_N.
DR   PANTHER; PTHR23107; PTHR23107; 1.
DR   Pfam; PF05030; SSXT; 1.
PE   2: Evidence at transcript level;
KW   Activator; Calcium; Chromatin regulator; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..403
FT                   /note="Calcium-responsive transactivator"
FT                   /id="PRO_0000391348"
FT   REGION          1..148
FT                   /note="N-terminal auto-inhibitory domain"
FT   REGION          72..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..238
FT                   /note="Methionine-rich intra-molecular domain"
FT                   /evidence="ECO:0000250"
FT   REGION          152..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..324
FT                   /note="MFD domain"
FT                   /evidence="ECO:0000250"
FT   REGION          318..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..403
FT                   /note="Necessary for nuclear localization"
FT                   /evidence="ECO:0000250"
FT   MOTIF           50..53
FT                   /note="SH2-binding"
FT                   /evidence="ECO:0000255"
FT   MOTIF           360..363
FT                   /note="SH2-binding"
FT                   /evidence="ECO:0000255"
FT   MOTIF           378..386
FT                   /note="SH3-binding"
FT                   /evidence="ECO:0000255"
FT   MOTIF           398..401
FT                   /note="SH2-binding"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        241..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  44217 MW;  D285EC20AB8EC2FC CRC64;
     MSVAFASARP RGKGEVTQQT IQKMLDENHH LIQCIMDYQS KGKTAECTQY QQILHRNLVY
     LATIADSNQN MQSLLPAPPT QNMNLGPGGM SQTGPSQTLH SQGNLSEALG SSLPPSSIMQ
     GQISNGPNHV SMQQSGQTTL PTTTMSMAVS THGSAPGYSH TVPSSQNVPM QNQGSIGNYV
     SRANMNMPSN PVTMMHQQAT SSHYTSAQAG SQHYQGQPSI AMMNQSSQGS SMMGQRPLGP
     YRPSQQGSSQ QYLGQEEYYS EQYGHSQGSS EAMTPQYYTD AGHGDYSYQQ SSYGEQSYER
     TFEDSSQHYY EGGNAQYSQQ QTGYQQGSGQ QQAYSQQQYS NQQNYPGQQQ GYVPAQGASS
     QYSGYQQGQG QQYASYRTSQ TTSTAQQQRP YGYEQGQYGN YQQ