CRF1_ARATH
ID CRF1_ARATH Reviewed; 287 AA.
AC O82503;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Ethylene-responsive transcription factor CRF1;
DE AltName: Full=Protein CYTOKININ RESPONSE FACTOR 1;
GN Name=CRF1; Synonyms=ERF063; OrderedLocusNames=At4g11140;
GN ORFNames=F2P3.5, T22B4.120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pan Y., Gong W., Liu D., Fu Q., Mei W.-Q., Song W.-Q., Ma L.-G., Luo J.-C.,
RA Deng X.-W., Zhu Y.-X.;
RT "Molecular cloning, expression, phylogenetic and functional
RT characterization of the Arabidopsis AP2/EREBP transcription factor
RT family.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16832061; DOI=10.1073/pnas.0602038103;
RA Rashotte A.M., Mason M.G., Hutchison C.E., Ferreira F.J., Schaller G.E.,
RA Kieber J.J.;
RT "A subset of Arabidopsis AP2 transcription factors mediates cytokinin
RT responses in concert with a two-component pathway.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11081-11085(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
CC -!- FUNCTION: Component of the cytokinin signaling pathway involved in
CC cotyledons, leaves, and embryos development. Probably acts as a
CC transcriptional activator. Binds to the GCC-box pathogenesis-related
CC promoter element. May be involved in the regulation of gene expression
CC by stress factors and by components of stress signal transduction
CC pathways (By similarity). {ECO:0000250, ECO:0000269|PubMed:16832061}.
CC -!- INTERACTION:
CC O82503; Q9SHJ1: At1g06460; NbExp=3; IntAct=EBI-5567050, EBI-25516773;
CC O82503; A0A178VXZ1: At2g32600; NbExp=3; IntAct=EBI-5567050, EBI-25521884;
CC O82503; Q9SUQ2: CRF2; NbExp=3; IntAct=EBI-5567050, EBI-5567273;
CC O82503; Q9FK12: CRF3; NbExp=3; IntAct=EBI-5567050, EBI-5567993;
CC O82503; Q9SUE3: CRF4; NbExp=4; IntAct=EBI-5567050, EBI-5567027;
CC O82503; O82339: CRF5; NbExp=3; IntAct=EBI-5567050, EBI-5567180;
CC O82503; Q9FMC8: OFP13; NbExp=3; IntAct=EBI-5567050, EBI-15204858;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16832061}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00366, ECO:0000269|PubMed:16832061}.
CC Note=Relocalization from the cytoplasm into the nucleus is induced by
CC cytokinins.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
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DR EMBL; AY560849; AAT44916.1; -; mRNA.
DR EMBL; AF080120; AAC35537.1; -; Genomic_DNA.
DR EMBL; AL049876; CAB43049.1; -; Genomic_DNA.
DR EMBL; AL161531; CAB81215.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82977.1; -; Genomic_DNA.
DR EMBL; BT025176; ABE77414.1; -; mRNA.
DR PIR; T01919; T01919.
DR RefSeq; NP_192852.1; NM_117184.4.
DR AlphaFoldDB; O82503; -.
DR SMR; O82503; -.
DR BioGRID; 12014; 22.
DR IntAct; O82503; 22.
DR STRING; 3702.AT4G11140.1; -.
DR PaxDb; O82503; -.
DR PRIDE; O82503; -.
DR EnsemblPlants; AT4G11140.1; AT4G11140.1; AT4G11140.
DR GeneID; 826715; -.
DR Gramene; AT4G11140.1; AT4G11140.1; AT4G11140.
DR KEGG; ath:AT4G11140; -.
DR Araport; AT4G11140; -.
DR TAIR; locus:2136078; AT4G11140.
DR eggNOG; ENOG502R7AV; Eukaryota.
DR HOGENOM; CLU_062946_1_0_1; -.
DR InParanoid; O82503; -.
DR OMA; ISIEPCA; -.
DR OrthoDB; 1269518at2759; -.
DR PhylomeDB; O82503; -.
DR PRO; PR:O82503; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O82503; baseline and differential.
DR Genevisible; O82503; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0048825; P:cotyledon development; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; Cytokinin signaling pathway; Cytoplasm; DNA-binding;
KW Ethylene signaling pathway; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..287
FT /note="Ethylene-responsive transcription factor CRF1"
FT /id="PRO_0000297918"
FT DNA_BIND 86..143
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
SQ SEQUENCE 287 AA; 31545 MW; 2EB60595A2F11CF4 CRC64;
METEKKVSLP RILRISVTDP YATDSSSDEE EEVDFDALST KRRRVKKYVK EVVLDSVVSD
KEKPMKKKRK KRVVTVPVVV TTATRKFRGV RQRPWGKWAA EIRDPSRRVR VWLGTFDTAE
EAAIVYDNAA IQLRGPNAEL NFPPPPVTEN VEEASTEVKG VSDFIIGGGE CLRSPVSVLE
SPFSGESTAV KEEFVGVSTA EIVVKKEPSF NGSDFSAPLF SDDDVFGFST SMSESFGGDL
FGDNLFADMS FGSGFGFGSG SGFSSWHVED HFQDIGDLFG SDPVLTV
