ID   CRF2_CATCO              Reviewed;         162 AA.
AC   P25308;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Corticoliberin-2;
DE   AltName: Full=Corticotropin-releasing factor 2;
DE            Short=CRF 2;
DE   AltName: Full=Corticotropin-releasing hormone 2;
DE   Flags: Precursor;
GN   Name=crf2;
OS   Catostomus commersonii (White sucker) (Cyprinus commersonnii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Catostomoidei; Catostomidae; Catostomus.
OX   NCBI_TaxID=7971;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT PHE-160.
RC   TISSUE=Hypothalamus;
RX   PubMed=1726976;
RA   Morley S.D., Schonrock C., Richter D., Okawara Y., Lederis K.;
RT   "Corticotropin-releasing factor (CRF) gene family in the brain of the
RT   teleost fish Catostomus commersoni (white sucker): molecular analysis
RT   predicts distinct precursors for two CRFs and one urotensin I peptide.";
RL   Mol. Mar. Biol. Biotechnol. 1:48-57(1991).
CC   -!- FUNCTION: This hormone from hypothalamus regulates the release of
CC       corticotropin from pituitary gland.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; X58784; CAA41589.1; -; mRNA.
DR   PIR; S14597; S14597.
DR   AlphaFoldDB; P25308; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT   PROPEP          25..119
FT                   /id="PRO_0000006228"
FT   PEPTIDE         120..160
FT                   /note="Corticoliberin-2"
FT                   /id="PRO_0000006229"
FT   REGION          57..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         160
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:1726976"
SQ   SEQUENCE   162 AA;  18605 MW;  FB4E72E8987ABDD4 CRC64;
     MRLNFLVTTM ALLVAFPPPY ECRAIDSSSN QPVTDPDEER QSPAVLARMG EEYFIRLGNR
     NKNSPRSPPD TYPEASQYSK RALQLQLTQR VLEGKVGNVG RWDGNYALRA LDSEERERRS
     EEPPISLDLT FHLLREVLEM ARAEQLVQQA HSNRKMMEIF GK