CRF6_ARATH
ID CRF6_ARATH Reviewed; 315 AA.
AC Q9M374;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Ethylene-responsive transcription factor CRF6;
DE AltName: Full=Protein CYTOKININ RESPONSE FACTOR 6;
GN Name=CRF6; Synonyms=ERF067; OrderedLocusNames=At3g61630;
GN ORFNames=F15G16.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP FUNCTION, INDUCTION BY CYTOKININS, AND SUBCELLULAR LOCATION.
RX PubMed=16832061; DOI=10.1073/pnas.0602038103;
RA Rashotte A.M., Mason M.G., Hutchison C.E., Ferreira F.J., Schaller G.E.,
RA Kieber J.J.;
RT "A subset of Arabidopsis AP2 transcription factors mediates cytokinin
RT responses in concert with a two-component pathway.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11081-11085(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
CC -!- FUNCTION: Component of the cytokinin signaling pathway involved in
CC cotyledons, leaves, and embryos development. Probably acts as a
CC transcriptional activator. Binds to the GCC-box pathogenesis-related
CC promoter element. May be involved in the regulation of gene expression
CC by stress factors and by components of stress signal transduction
CC pathways (By similarity). {ECO:0000250, ECO:0000269|PubMed:16832061}.
CC -!- INTERACTION:
CC Q9M374; Q9SUQ2: CRF2; NbExp=4; IntAct=EBI-5568101, EBI-5567273;
CC Q9M374; Q9FK12: CRF3; NbExp=3; IntAct=EBI-5568101, EBI-5567993;
CC Q9M374; Q9SUE3: CRF4; NbExp=4; IntAct=EBI-5568101, EBI-5567027;
CC Q9M374; O82339: CRF5; NbExp=3; IntAct=EBI-5568101, EBI-5567180;
CC Q9M374; Q8W4I5: ERF069; NbExp=3; IntAct=EBI-5568101, EBI-5568301;
CC Q9M374; Q9C995: ERF070; NbExp=3; IntAct=EBI-5568101, EBI-5568333;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16832061}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00366, ECO:0000269|PubMed:16832061}.
CC Note=Relocalization from the cytoplasm into the nucleus is induced by
CC cytokinins.
CC -!- INDUCTION: By cytokinins. {ECO:0000269|PubMed:16832061}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
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DR EMBL; AL132959; CAB71093.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80234.1; -; Genomic_DNA.
DR EMBL; BX822244; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T47955; T47955.
DR RefSeq; NP_191722.1; NM_116028.4.
DR AlphaFoldDB; Q9M374; -.
DR SMR; Q9M374; -.
DR BioGRID; 10650; 24.
DR IntAct; Q9M374; 21.
DR STRING; 3702.AT3G61630.1; -.
DR PaxDb; Q9M374; -.
DR PRIDE; Q9M374; -.
DR EnsemblPlants; AT3G61630.1; AT3G61630.1; AT3G61630.
DR GeneID; 825336; -.
DR Gramene; AT3G61630.1; AT3G61630.1; AT3G61630.
DR KEGG; ath:AT3G61630; -.
DR Araport; AT3G61630; -.
DR TAIR; locus:2076720; AT3G61630.
DR eggNOG; ENOG502RYD1; Eukaryota.
DR HOGENOM; CLU_062946_1_0_1; -.
DR InParanoid; Q9M374; -.
DR OMA; NLEHDYG; -.
DR OrthoDB; 1430404at2759; -.
DR PhylomeDB; Q9M374; -.
DR PRO; PR:Q9M374; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M374; baseline and differential.
DR Genevisible; Q9M374; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0048825; P:cotyledon development; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; Cytokinin signaling pathway; Cytoplasm; DNA-binding;
KW Ethylene signaling pathway; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..315
FT /note="Ethylene-responsive transcription factor CRF6"
FT /id="PRO_0000290403"
FT DNA_BIND 104..161
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT CONFLICT 61
FT /note="R -> S (in Ref. 3; BX822244)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="H -> N (in Ref. 3; BX822244)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 35573 MW; 2FD164568E84D3E0 CRC64;
MERRTRRVKF TENRTVTNVA ATPSNGSPRL VRITVTDPFA TDSSSDDDDN NNVTVVPRVK
RYVKEIRFCQ GESSSSTAAR KGKHKEEESV VVEDDVSTSV KPKKYRGVRQ RPWGKFAAEI
RDPSSRTRIW LGTFVTAEEA AIAYDRAAIH LKGPKALTNF LTPPTPTPVI DLQTVSACDY
GRDSRQSLHS PTSVLRFNVN EETEHEIEAI ELSPERKSTV IKEEEESSAG LVFPDPYLLP
DLSLAGECFW DTEIAPDLLF LDEETKIQST LLPNTEVSKQ GENETEDFEF GLIDDFESSP
WDVDHFFDHH HHSFD
