ID   CRFA1_CONTE             Reviewed;          62 AA.
AC   P0DM26;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Conorfamide-Tx1 {ECO:0000250|UniProtKB:P0DOZ7, ECO:0000303|PubMed:30243794};
DE            Short=CNF-Tx1 {ECO:0000303|PubMed:30243794};
DE   AltName: Full=Cono-RFamide-Tx1 {ECO:0000250|UniProtKB:P0DOZ7, ECO:0000303|PubMed:30243794};
DE   Flags: Precursor;
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SYNTHESIS OF 27-46.
RX   PubMed=30243794; DOI=10.1016/j.toxicon.2018.09.002;
RA   Espino S.S., Robinson S.D., Safavi-Hemami H., Gajewiak J., Yang W.,
RA   Olivera B.M., Liu Q.;
RT   "Conopeptides promote itch through human itch receptor hMgprX1.";
RL   Toxicon 154:28-34(2018).
CC   -!- FUNCTION: This peptide does not show activity on human and mouse
CC       sensory neuron-specific G-protein coupled receptors MRGPRX1.
CC       {ECO:0000269|PubMed:30243794}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:30243794}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30243794}.
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DM26; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..26
FT                   /evidence="ECO:0000305|PubMed:30243794"
FT                   /id="PRO_0000446244"
FT   PEPTIDE         27..46
FT                   /note="Conorfamide-Tx1"
FT                   /evidence="ECO:0000305|PubMed:30243794"
FT                   /id="PRO_0000446245"
FT   PROPEP          47..62
FT                   /evidence="ECO:0000305|PubMed:30243794"
FT                   /id="PRO_0000446246"
FT   MOD_RES         46
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P0DOZ7"
SQ   SEQUENCE   62 AA;  7007 MW;  127FDC6DB6EB8171 CRC64;
     MSGRGFLLLA LLLLVTVEAT KVEKNKPGVL DIPVKSNSDD DSIFRYGRRD MQSPLLSERL
     RF