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CRF_BOVIN
ID   CRF_BOVIN               Reviewed;         190 AA.
AC   Q95MI6; A6QL82;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Corticoliberin;
DE   AltName: Full=Corticotropin-releasing factor;
DE            Short=CRF;
DE   AltName: Full=Corticotropin-releasing hormone;
DE   Flags: Precursor;
GN   Name=CRH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS PRO-4; ASN-45 AND HIS-77.
RX   PubMed=15771721; DOI=10.1111/j.1365-2052.2005.01255.x;
RA   Buchanan F.C., Thue T.D., Yu P., Winkelman-Sim D.C.;
RT   "Single nucleotide polymorphisms in the corticotrophin-releasing hormone
RT   and pro-opiomelancortin genes are associated with growth and carcass yield
RT   in beef cattle.";
RL   Anim. Genet. 36:127-131(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hormone regulating the release of corticotropin from
CC       pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial
CC       cells, hence may influence gut microbiota profile (By similarity).
CC       {ECO:0000250|UniProtKB:P06296, ECO:0000250|UniProtKB:Q8CIT0}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal
CC       extracellular domain). {ECO:0000250|UniProtKB:P06850}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06296}.
CC   -!- TISSUE SPECIFICITY: Produced by the hypothalamus. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; AF340152; AAK83231.1; -; Genomic_DNA.
DR   EMBL; BC147872; AAI47873.1; -; mRNA.
DR   RefSeq; NP_001013418.2; NM_001013400.2.
DR   RefSeq; XP_005215511.1; XM_005215454.3.
DR   AlphaFoldDB; Q95MI6; -.
DR   STRING; 9913.ENSBTAP00000044298; -.
DR   PaxDb; Q95MI6; -.
DR   PRIDE; Q95MI6; -.
DR   Ensembl; ENSBTAT00000047063; ENSBTAP00000044298; ENSBTAG00000033128.
DR   GeneID; 280755; -.
DR   KEGG; bta:280755; -.
DR   CTD; 1392; -.
DR   VEuPathDB; HostDB:ENSBTAG00000033128; -.
DR   VGNC; VGNC:27707; CRH.
DR   eggNOG; ENOG502S25G; Eukaryota.
DR   GeneTree; ENSGT00940000154473; -.
DR   HOGENOM; CLU_136288_0_0_1; -.
DR   InParanoid; Q95MI6; -.
DR   OMA; HNNRKLM; -.
DR   OrthoDB; 1532326at2759; -.
DR   TreeFam; TF332956; -.
DR   Reactome; R-BTA-373080; Class B/2 (Secretin family receptors).
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000033128; Expressed in oocyte and 15 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0017045; F:corticotropin-releasing hormone activity; IBA:GO_Central.
DR   GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR   GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR   GO; GO:0006704; P:glucocorticoid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
DR   GO; GO:0030324; P:lung development; IEA:Ensembl.
DR   GO; GO:0032811; P:negative regulation of epinephrine secretion; IBA:GO_Central.
DR   GO; GO:0070093; P:negative regulation of glucagon secretion; IBA:GO_Central.
DR   GO; GO:0051461; P:positive regulation of corticotropin secretion; IEA:Ensembl.
DR   GO; GO:0051464; P:positive regulation of cortisol secretion; IBA:GO_Central.
DR   GO; GO:2000310; P:regulation of NMDA receptor activity; IEA:Ensembl.
DR   GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..147
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006208"
FT   PEPTIDE         148..188
FT                   /note="Corticoliberin"
FT                   /id="PRO_0000006209"
FT   REGION          33..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         188
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250"
FT   VARIANT         4
FT                   /note="R -> P"
FT                   /evidence="ECO:0000269|PubMed:15771721"
FT   VARIANT         45
FT                   /note="S -> N"
FT                   /evidence="ECO:0000269|PubMed:15771721"
FT   VARIANT         77
FT                   /note="D -> H"
FT                   /evidence="ECO:0000269|PubMed:15771721"
SQ   SEQUENCE   190 AA;  20777 MW;  6BD8F45F245FBCF0 CRC64;
     MRLRLLVSVG VLLVALLPSP PCRALLSRGP IPGARQASQH PQPLSFFQPP PQPQEPQALP
     TLLRVGEEYF LRLGNLDETR AAPLSPAASP LASRSSSRLS PDKVAANFFR ALLQPRRPFD
     SPAGPAERGT ENALGSRQEA PAARKRRSQE PPISLDLTFH LLREVLEMTK ADQLAQQAHN
     NRKLLDIAGK
 
 
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