ID   CRF_CANLF               Reviewed;         196 AA.
AC   P49926; Q75QJ9;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Corticoliberin;
DE   AltName: Full=Corticotropin-releasing factor;
DE            Short=CRF;
DE   AltName: Full=Corticotropin-releasing hormone;
DE   Flags: Precursor;
GN   Name=CRH;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kansaku N., Yamagishi K., Mizushima S.;
RT   "PCR cloning of dog corticotropin releasing hormone gene.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-196, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=Mongrel; TISSUE=Blood;
RX   PubMed=7969821; DOI=10.1016/0143-4179(94)90010-8;
RA   Mol J.A., van Wolferen M., Kwant M., Meloen R.;
RT   "Predicted primary and antigenic structure of canine corticotropin
RT   releasing hormone.";
RL   Neuropeptides 27:7-13(1994).
CC   -!- FUNCTION: Hormone regulating the release of corticotropin from
CC       pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial
CC       cells, hence may influence gut microbiota profile (By similarity).
CC       {ECO:0000250|UniProtKB:P06296, ECO:0000250|UniProtKB:Q8CIT0}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal
CC       extracellular domain). {ECO:0000250|UniProtKB:P06850}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06296}.
CC   -!- TISSUE SPECIFICITY: Produced by the hypothalamus.
CC       {ECO:0000269|PubMed:7969821}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB32322.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAB32322.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR   EMBL; AB162117; BAD10983.1; -; Genomic_DNA.
DR   EMBL; S74126; AAB32322.1; ALT_SEQ; Genomic_DNA.
DR   PIR; I46994; I46994.
DR   AlphaFoldDB; P49926; -.
DR   STRING; 9612.ENSCAFP00000040748; -.
DR   PaxDb; P49926; -.
DR   eggNOG; ENOG502S25G; Eukaryota.
DR   InParanoid; P49926; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..153
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006210"
FT   PEPTIDE         154..194
FT                   /note="Corticoliberin"
FT                   /id="PRO_0000006211"
FT   REGION          122..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..158
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         194
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   196 AA;  21547 MW;  A59DE46526C801F8 CRC64;
     MRLPLLLSAG VLLVVSLPCP PCRALLSRGP IPGARQAAQH PQPLDFFQLP PQPQQPQQPQ
     ARPVLYRMGE EYFLRLGNLN KSPAAPLLPA SSPVAGGSGS RLSPDEAAAN FFRALLQQLP
     LPRRQLDSPA GPAERGEENA LGSRQETPER ERRSEEPPIS LDLTFHLLRE VLEMARAEQL
     AQQAHSNRKL MEIIGK