CRF_PIG
ID CRF_PIG Reviewed; 191 AA.
AC P06296; O62637; Q0ZLZ2; Q8HZV1;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Corticoliberin;
DE AltName: Full=Corticotropin-releasing factor;
DE Short=CRF;
DE AltName: Full=Corticotropin-releasing hormone;
DE Flags: Precursor;
GN Name=CRH;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9734873; DOI=10.2527/1998.7682205x;
RA Mimmack M.L., Parrott R.F., Vellucci S.V.;
RT "Molecular cloning of the porcine corticotropin-releasing factor gene.";
RL J. Anim. Sci. 76:2205-2206(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12030933; DOI=10.1046/j.1365-2052.2002.t01-3-00876.x;
RA Wimmers K., Murani E., Ponsuksili S., Schellander K.;
RT "Sequence variation and linkage mapping of the porcine corticotropin
RT releasing hormone (CRH) gene.";
RL Anim. Genet. 33:233-234(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16483545; DOI=10.1016/j.bbrc.2006.01.143;
RA Murani E., Muraniova M., Ponsuksili S., Schellander K., Wimmers K.;
RT "Molecular characterization and evidencing of the porcine CRH gene as a
RT functional-positional candidate for growth and body composition.";
RL Biochem. Biophys. Res. Commun. 342:394-405(2006).
RN [4]
RP PROTEIN SEQUENCE OF 149-189, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=3878520; DOI=10.1073/pnas.82.24.8762;
RA Patthy M., Horvath J., Mason-Garcia M., Szoke B., Schlesinger D.H.,
RA Schally A.V.;
RT "Isolation and amino acid sequence of corticotropin-releasing factor from
RT pig hypothalami.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:8762-8766(1985).
CC -!- FUNCTION: Hormone regulating the release of corticotropin from
CC pituitary gland (PubMed:3878520). Induces NLRP6 in intestinal
CC epithelial cells, hence may influence gut microbiota profile (By
CC similarity). {ECO:0000250|UniProtKB:Q8CIT0,
CC ECO:0000269|PubMed:3878520}.
CC -!- SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal
CC extracellular domain). {ECO:0000250|UniProtKB:P06850}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3878520}.
CC -!- TISSUE SPECIFICITY: Produced by the hypothalamus.
CC {ECO:0000269|PubMed:3878520}.
CC -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC factor/urotensin I family. {ECO:0000305}.
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DR EMBL; Y15159; CAA75424.1; -; Genomic_DNA.
DR EMBL; AF440229; AAN40888.1; -; Genomic_DNA.
DR EMBL; DQ358705; ABD34973.1; -; Genomic_DNA.
DR PIR; A01404; RHPGCE.
DR RefSeq; NP_001106533.1; NM_001113062.1.
DR RefSeq; XP_013852166.1; XM_013996712.1.
DR AlphaFoldDB; P06296; -.
DR STRING; 9823.ENSSSCP00000006626; -.
DR PaxDb; P06296; -.
DR PRIDE; P06296; -.
DR Ensembl; ENSSSCT00000006811; ENSSSCP00000006626; ENSSSCG00000006215.
DR Ensembl; ENSSSCT00000090438; ENSSSCP00000067099; ENSSSCG00000006215.
DR Ensembl; ENSSSCT00015020175; ENSSSCP00015007900; ENSSSCG00015015252.
DR Ensembl; ENSSSCT00015020200; ENSSSCP00015007907; ENSSSCG00015015252.
DR Ensembl; ENSSSCT00025029486; ENSSSCP00025012531; ENSSSCG00025021688.
DR Ensembl; ENSSSCT00025029504; ENSSSCP00025012539; ENSSSCG00025021688.
DR Ensembl; ENSSSCT00030046261; ENSSSCP00030020829; ENSSSCG00030033445.
DR Ensembl; ENSSSCT00030046286; ENSSSCP00030020845; ENSSSCG00030033445.
DR Ensembl; ENSSSCT00035023013; ENSSSCP00035008526; ENSSSCG00035017872.
DR Ensembl; ENSSSCT00035023017; ENSSSCP00035008528; ENSSSCG00035017872.
DR Ensembl; ENSSSCT00040039833; ENSSSCP00040016691; ENSSSCG00040029641.
DR Ensembl; ENSSSCT00040039880; ENSSSCP00040016712; ENSSSCG00040029641.
DR Ensembl; ENSSSCT00045018533; ENSSSCP00045012779; ENSSSCG00045010902.
DR Ensembl; ENSSSCT00045018560; ENSSSCP00045012796; ENSSSCG00045010902.
DR Ensembl; ENSSSCT00050023611; ENSSSCP00050009950; ENSSSCG00050017351.
DR Ensembl; ENSSSCT00050023618; ENSSSCP00050009952; ENSSSCG00050017351.
DR Ensembl; ENSSSCT00055021798; ENSSSCP00055017255; ENSSSCG00055011116.
DR Ensembl; ENSSSCT00055021821; ENSSSCP00055017271; ENSSSCG00055011116.
DR Ensembl; ENSSSCT00060070263; ENSSSCP00060030326; ENSSSCG00060051620.
DR Ensembl; ENSSSCT00060070268; ENSSSCP00060030328; ENSSSCG00060051620.
DR Ensembl; ENSSSCT00065094580; ENSSSCP00065041366; ENSSSCG00065068899.
DR Ensembl; ENSSSCT00065094586; ENSSSCP00065041369; ENSSSCG00065068899.
DR Ensembl; ENSSSCT00070040731; ENSSSCP00070034176; ENSSSCG00070020495.
DR GeneID; 100127468; -.
DR KEGG; ssc:100127468; -.
DR CTD; 1392; -.
DR VGNC; VGNC:86992; CRH.
DR eggNOG; ENOG502S25G; Eukaryota.
DR GeneTree; ENSGT00940000154473; -.
DR HOGENOM; CLU_136288_0_0_1; -.
DR InParanoid; P06296; -.
DR OMA; HNNRKLM; -.
DR OrthoDB; 1532326at2759; -.
DR TreeFam; TF332956; -.
DR Reactome; R-SSC-373080; Class B/2 (Secretin family receptors).
DR Reactome; R-SSC-418555; G alpha (s) signalling events.
DR Proteomes; UP000008227; Chromosome 4.
DR Proteomes; UP000314985; Chromosome 4.
DR Bgee; ENSSSCG00000006215; Expressed in occipital cortex and 16 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0017045; F:corticotropin-releasing hormone activity; IBA:GO_Central.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR GO; GO:0006704; P:glucocorticoid biosynthetic process; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0032811; P:negative regulation of epinephrine secretion; IBA:GO_Central.
DR GO; GO:0070093; P:negative regulation of glucagon secretion; IBA:GO_Central.
DR GO; GO:0051461; P:positive regulation of corticotropin secretion; IEA:Ensembl.
DR GO; GO:0051464; P:positive regulation of cortisol secretion; IBA:GO_Central.
DR GO; GO:2000310; P:regulation of NMDA receptor activity; IEA:Ensembl.
DR GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
DR InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR InterPro; IPR000187; CRF.
DR InterPro; IPR003620; Urocortin_CRF.
DR PANTHER; PTHR15035; PTHR15035; 1.
DR Pfam; PF00473; CRF; 1.
DR PRINTS; PR01612; CRFFAMILY.
DR SMART; SM00039; CRF; 1.
DR PROSITE; PS00511; CRF; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..148
FT /evidence="ECO:0000269|PubMed:3878520"
FT /id="PRO_0000006216"
FT PEPTIDE 149..189
FT /note="Corticoliberin"
FT /id="PRO_0000006217"
FT REGION 115..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 189
FT /note="Isoleucine amide"
FT /evidence="ECO:0000250|UniProtKB:P06850"
FT CONFLICT 7
FT /note="V -> A (in Ref. 2; AAN40888)"
FT /evidence="ECO:0000305"
FT CONFLICT 39..40
FT /note="QH -> HS (in Ref. 1; CAA75424)"
FT /evidence="ECO:0000305"
FT CONFLICT 79
FT /note="S -> N (in Ref. 1; CAA75424)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="P -> R (in Ref. 1; CAA75424)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="I -> F (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 191 AA; 20997 MW; 587E58F516AB9006 CRC64;
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VLGARQAPQH PQALDFLQPQ QQPQQPQPRP
VLLRMGEEYF LRLGNLNKSP AAPLSPASSP LTGSSGNRPD EVAANFFRAL LQQLPLPRRP
LDSPSGPAER GAENALSSRQ EAPERERRSE EPPISLDLTF HLLREVLEMA RAEQLAQQAH
SNRKLMEIIG K
