ID   CRF_XENLA               Reviewed;         162 AA.
AC   P49188; Q0GGT6;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Corticoliberin;
DE   AltName: Full=Corticotropin-releasing factor;
DE            Short=CRF;
DE   AltName: Full=Corticotropin-releasing hormone;
DE   Flags: Precursor;
GN   Name=crh;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1448118; DOI=10.1210/mend.6.10.1448118;
RA   Stenzel-Poore M.P., Heldwein K.A., Stenzel P., Lee S., Vale W.W.;
RT   "Characterization of the genomic corticotropin-releasing factor (CRF) gene
RT   from Xenopus laevis: two members of the CRF family exist in amphibians.";
RL   Mol. Endocrinol. 6:1716-1724(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Yao M., Stenzel-Poore M.P., Denver R.J.;
RT   "Structural and functional analysis of corticotropin-releasing factor genes
RT   of the South African clawed frog, Xenopus laevis.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This hormone from hypothalamus regulates the release of
CC       corticotropin from pituitary gland. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; S50096; AAB24277.1; -; Genomic_DNA.
DR   EMBL; DQ865136; ABI24191.1; -; Genomic_DNA.
DR   PIR; A45362; A45362.
DR   RefSeq; NP_001165681.1; NM_001172210.1.
DR   AlphaFoldDB; P49188; -.
DR   GeneID; 100337609; -.
DR   KEGG; xla:100337609; -.
DR   CTD; 100337609; -.
DR   Xenbase; XB-GENE-6464312; crh.L.
DR   OrthoDB; 1532326at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 100337609; Expressed in internal ear and 1 other tissue.
DR   GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..119
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006222"
FT   PEPTIDE         120..160
FT                   /note="Corticoliberin"
FT                   /id="PRO_0000006223"
FT   REGION          91..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         160
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   162 AA;  17880 MW;  02E6906ACA0636CB CRC64;
     MKFQLWVSTG ILLVSLLPCH ECRAFIKSPA SSPGALLPAL SNSQPFLLRM GEEYFLRLGN
     LHKHSPGSFP EASAGNFVRA VQQLQAQQWS SQPGMRAASL DGADSPYSAQ EDPTEKAKRA
     EEPPISLDLT FHLLREVLEM ARAEQIAQQA HSNRKLMDII GK