ID   CRG12_LITCT             Reviewed;         177 AA.
AC   Q91321;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Gamma-crystallin M1-2;
DE            Short=Gamma M1-2;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=8838595; DOI=10.1007/bf01886816;
RA   Lu S.-F., Pan F.-M., Chiou S.-H.;
RT   "Characterization of gamma-crystallin from the eye lens of bullfrog:
RT   complexity of gamma-crystallin multigene family as revealed by sequence
RT   comparison among different amphibian species.";
RL   J. Protein Chem. 15:103-113(1996).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; X86081; CAA60036.1; -; mRNA.
DR   PIR; S52843; S52843.
DR   AlphaFoldDB; Q91321; -.
DR   SMR; Q91321; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat.
FT   CHAIN           1..177
FT                   /note="Gamma-crystallin M1-2"
FT                   /id="PRO_0000057571"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          91..131
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          132..174
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..90
FT                   /note="Connecting peptide"
SQ   SEQUENCE   177 AA;  20850 MW;  209015159EEA7277 CRC64;
     MGKIIFYEDR NFQGRSYECS NDNPDLQPNF NACNSVRVEN GCWMIYERPN YMGHQYFLKR
     GEYPDYQQCQ GLNDSPQSSR LLSQNLGIGT NKLRVYERGD SKGEMMEFLE DCPNVYDRFC
     SHEIHSCNVL DGYWIFYELP NYKGKQYLLR PGEYKRFTDW GSQTAKVGSF RRVIGIC