ID   CRG1_RANTE              Reviewed;         133 AA.
AC   P02530;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Gamma-crystallin 1;
DE   AltName: Full=Gamma-crystallin I;
DE   Flags: Fragment;
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6982831; DOI=10.1016/0014-5793(82)80942-3;
RA   Tomarev S.I., Krayev A.S., Skryabin K.G., Bayev A.A., Gause G.G. Jr.;
RT   "The nucleotide sequence of a cloned cDNA corresponding to one of the
RT   gamma-crystallins from the eye lens of the frog Rana temporaria.";
RL   FEBS Lett. 146:314-318(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tomarev S.I., Krayev A.S., Skryabin K.G., Gause G.G. Jr., Bayev A.A.;
RT   "Presence of internal duplication in mRNA coding one of the gamma-
RT   crystallins of the crystalline lens of the eye of the frog Rana
RT   temporaria.";
RL   Dokl. Biochem. 263:117-120(1982).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- MISCELLANEOUS: There are at least four genes coding for non-identical
CC       gamma crystallins in this multigene family.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; M24189; AAA49522.1; -; mRNA.
DR   EMBL; J00927; AAA49515.1; -; mRNA.
DR   EMBL; J00928; AAA49520.1; -; mRNA.
DR   PIR; A02936; CYFGG.
DR   AlphaFoldDB; P02530; -.
DR   SMR; P02530; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 3.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat.
FT   CHAIN           <1..133
FT                   /note="Gamma-crystallin 1"
FT                   /id="PRO_0000057572"
FT   DOMAIN          <1..41
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          47..87
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..130
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          42..46
FT                   /note="Connecting peptide"
FT   NON_TER         1
SQ   SEQUENCE   133 AA;  16569 MW;  65653149B2C4195E CRC64;
     WMLYEHPNYT GHQYFLRRGE YPDFQQWMGL NDSIRSCRVI PQHRGSFRLR IYEREEFRGQ
     MMEFTEDCPQ VHEEFNYHDI HSCNVLEGHW ILYEQPNYRG RQYYLRPGEY RRYTEWGAVT
     PRVGAFRRVQ EMF