ID   CRG2_RANTE              Reviewed;         169 AA.
AC   P02531;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Gamma-crystallin 2;
DE   AltName: Full=Gamma-crystallin II;
DE   Flags: Fragment;
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-168.
RX   PubMed=6610602; DOI=10.1016/0378-1119(84)90074-x;
RA   Tomarev S.I., Zinovieva R.D., Chalovka P., Krayev A.S., Skryabin K.G.,
RA   Gause G.G. Jr.;
RT   "Multiple genes coding for the frog eye lens gamma-crystallins.";
RL   Gene 27:301-308(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-168.
RA   Tomarev S.I., Zinovieva R.D., Dolgilevich S.M., Krayev A.S., Skryabin K.G.,
RA   Gause G.G. Jr.;
RT   "Gamma crystallins of the eye lens of the grass frog are coded by a family
RT   of multiple nonallelic genes.";
RL   Dokl. Biochem. 273:388-391(1984).
RN   [3]
RP   SEQUENCE REVISION TO 169.
RA   Tomarev S.I.;
RL   Submitted (SEP-1985) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- MISCELLANEOUS: There are at least four genes coding for non-identical
CC       gamma crystallins in this multigene family.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; K02264; AAA49516.1; -; mRNA.
DR   EMBL; X00775; CAA25351.1; -; mRNA.
DR   PIR; A02937; CYFGG2.
DR   PIR; T01783; T01783.
DR   AlphaFoldDB; P02531; -.
DR   SMR; P02531; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat.
FT   CHAIN           <1..169
FT                   /note="Gamma-crystallin 2"
FT                   /id="PRO_0000057573"
FT   DOMAIN          <1..34
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          35..77
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          83..123
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          124..166
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          78..82
FT                   /note="Connecting peptide"
FT   NON_TER         1
SQ   SEQUENCE   169 AA;  20160 MW;  EE0774A6111E4ADB CRC64;
     YEDRNFQGRC YECSGDCADL HSYFSRCNSI KVDSGCWMLY ERPNFLGHQY FLKKGEYPDY
     QQWMGFSDSV RSCKVIPQQK GPHKMKIYEK EELKGQMLEV LEDCPSVFEL FKNHDINSCN
     VLEGHWIFYE QPNYRGRQYF LKPGEYKRFS DWGSLNARVS SFRRVLDSC