ID   CRG2_RHIAS              Reviewed;          30 AA.
AC   P19865;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Gamma-II crystallin;
DE   Flags: Fragment;
OS   Rhizoprionodon acutus (Milk shark) (Scoliodon walbeemii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Carcharhinidae;
OC   Rhizoprionodon.
OX   NCBI_TaxID=34770;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Lens;
RX   PubMed=2261977; DOI=10.1016/0014-5793(90)81451-s;
RA   Chiou S.-H., Chen S.-W., Itoh T., Kaji H., Samejima T.;
RT   "Comparison of the gamma-crystallins isolated from eye lenses of shark and
RT   carp. Unique secondary and tertiary structure of shark gamma-crystallin.";
RL   FEBS Lett. 275:111-113(1990).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   AlphaFoldDB; P19865; -.
DR   SMR; P19865; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 1.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Eye lens protein; Repeat.
FT   CHAIN           1..>30
FT                   /note="Gamma-II crystallin"
FT                   /id="PRO_0000057579"
FT   DOMAIN          1..>30
FT                   /note="Beta/gamma crystallin 'Greek key'"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   NON_TER         30
SQ   SEQUENCE   30 AA;  3543 MW;  229E65B93CD7F68E CRC64;
     GKITFYEDRN FQGRCYECST DCPDLSPYFS