ID   CRG3_XENLA              Reviewed;         175 AA.
AC   P55940;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Gamma-crystallin-3;
DE   AltName: Full=Gamma-3-CRY;
DE   AltName: Full=Gamma-crystallin III;
GN   Name=cryg3; Synonyms=gcry3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8514186; DOI=10.1016/0378-1119(93)90562-h;
RA   Smolich B.D., Tarkington S.K., Saha M.S., Stathakis D.G., Grainger R.M.;
RT   "Characterization of Xenopus laevis gamma-crystallin-encoding genes.";
RL   Gene 128:189-195(1993).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M99581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; JN0682; JN0682.
DR   RefSeq; NP_001165551.1; NM_001172080.1.
DR   AlphaFoldDB; P55940; -.
DR   SMR; P55940; -.
DR   GeneID; 100337557; -.
DR   KEGG; xla:100337557; -.
DR   CTD; 100337557; -.
DR   Xenbase; XB-GENE-22169743; crygbl.1.S.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 100337557; Expressed in camera-type eye and 3 other tissues.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   3: Inferred from homology;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..175
FT                   /note="Gamma-crystallin-3"
FT                   /id="PRO_0000057603"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          89..129
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          130..172
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..88
FT                   /note="Connecting peptide"
SQ   SEQUENCE   175 AA;  21514 MW;  A333B00B0D60A087 CRC64;
     MGKIFFYEDK NFQGRSYECN SDCSDLSSYF NRCNSIRVES GNWILYEQPS YRGHQYYLWK
     GEYPDFQRWM GFNDSIRSCR MSPYHQGQYK MRISERGDFQ GQNMEFFEDC PNTYDRFRFR
     DIHSCNVFDG NWMFYEEPNY RGRQYYLRPG EYRRYSDWGA SSARIGSFRR VHHIF