ID   CRG5_XENLA              Reviewed;         132 AA.
AC   Q06255;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Gamma-crystallin-5;
DE   AltName: Full=Gamma-5-CRY;
DE   AltName: Full=Gamma-crystallin V;
DE   Flags: Fragment;
GN   Name=cryg5; Synonyms=gcry5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8514186; DOI=10.1016/0378-1119(93)90562-h;
RA   Smolich B.D., Tarkington S.K., Saha M.S., Stathakis D.G., Grainger R.M.;
RT   "Characterization of Xenopus laevis gamma-crystallin-encoding genes.";
RL   Gene 128:189-195(1993).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; M99583; AAA49694.1; -; Genomic_DNA.
DR   PIR; PN0546; PN0546.
DR   AlphaFoldDB; Q06255; -.
DR   SMR; Q06255; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 3.
PE   3: Inferred from homology;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           <1..132
FT                   /note="Gamma-crystallin-5"
FT                   /id="PRO_0000057605"
FT   DOMAIN          <1..40
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          46..86
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          87..129
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          41..45
FT                   /note="Connecting peptide"
FT   NON_TER         1
SQ   SEQUENCE   132 AA;  16461 MW;  CBA97C33E2F75377 CRC64;
     ILYEQPSYRG HQYYLWKGEY PDFQRWMGFN DSIRSCRMSP YHQGQYKMRI YERGDFQGQN
     MEFFEDCPNT YDRFRFRDIH SCNVFDGNWM FYEEPNYRGR QYYLRPGEYR RYSDWGASSA
     RIGSFRRVHH LV