CRGA_MOUSE
ID CRGA_MOUSE Reviewed; 174 AA.
AC P04345;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Gamma-crystallin A;
DE AltName: Full=Gamma-A-crystallin;
DE AltName: Full=Gamma-crystallin 4;
GN Name=Cryga;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6096855; DOI=10.1073/pnas.81.24.7762;
RA Breitman M.L., Lok S., Wistow G., Piatigorsky J., Treton J.A., Gold R.J.M.,
RA Tsui L.-C.;
RT "Gamma-crystallin family of the mouse lens: structural and evolutionary
RT relationships.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:7762-7766(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6330674; DOI=10.1093/nar/12.11.4517;
RA Lok S., Tsui L.-C., Shinohara T., Piatigorsky J., Gold R., Breitman M.L.;
RT "Analysis of the mouse gamma-crystallin gene family: assignment of multiple
RT cDNAs to discrete genomic sequences and characterization of a
RT representative gene.";
RL Nucleic Acids Res. 12:4517-4529(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC mouse lens.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; X00635; CAA25266.1; -; Genomic_DNA.
DR EMBL; X00654; CAA25275.1; -; Genomic_DNA.
DR EMBL; BC056430; AAH56430.1; -; mRNA.
DR CCDS; CCDS15014.1; -.
DR PIR; A02935; CYMSG4.
DR PIR; I48353; I48353.
DR RefSeq; NP_031800.1; NM_007774.3.
DR AlphaFoldDB; P04345; -.
DR SMR; P04345; -.
DR STRING; 10090.ENSMUSP00000058548; -.
DR PaxDb; P04345; -.
DR PRIDE; P04345; -.
DR ProteomicsDB; 283954; -.
DR Antibodypedia; 54429; 18 antibodies from 11 providers.
DR DNASU; 12964; -.
DR Ensembl; ENSMUST00000061497; ENSMUSP00000058548; ENSMUSG00000044429.
DR GeneID; 12964; -.
DR KEGG; mmu:12964; -.
DR UCSC; uc007bhk.1; mouse.
DR CTD; 1418; -.
DR MGI; MGI:88521; Cryga.
DR VEuPathDB; HostDB:ENSMUSG00000044429; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000156190; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; P04345; -.
DR OMA; TEDCPCI; -.
DR OrthoDB; 1220704at2759; -.
DR PhylomeDB; P04345; -.
DR BioGRID-ORCS; 12964; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Cryga; mouse.
DR PRO; PR:P04345; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P04345; protein.
DR Bgee; ENSMUSG00000044429; Expressed in lens of camera-type eye and 15 other tissues.
DR Genevisible; P04345; MM.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IMP:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin A"
FT /id="PRO_0000057595"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
SQ SEQUENCE 174 AA; 21149 MW; 169758B24919D632 CRC64;
MGKITFYEDR GFQGRCYECS SDCPNLQTYF SRCNSIRVDS GCWMLYERPN YQGYQYFLRR
GDYPDYQQWM GFSDSIRSCR SIPYTSSHRI RLYERDDYRG LVSELMDDCS CIHDRFRLHE
IYSMHVLEGC WVLYEMPNYR GRQYLLRPGD YRRYHDWGAM DAKVGSLRRV MDLY
