ID   CRGA_MYCTO              Reviewed;          93 AA.
AC   P9WP56; L0T422; P67376; P71581;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Cell division protein CrgA {ECO:0000255|HAMAP-Rule:MF_00631};
GN   Name=crgA {ECO:0000255|HAMAP-Rule:MF_00631}; OrderedLocusNames=MT0014;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Involved in cell division. Plays an important role in septal
CC       peptidoglycan synthesis and cell shape morphogenesis. May facilitate
CC       the recruitment of the peptidoglycan synthesis machinery to poles and
CC       septal zones and coordinate peptidoglycan synthesis at these sites (By
CC       similarity). {ECO:0000255|HAMAP-Rule:MF_00631}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00631};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00631}.
CC       Note=Localizes to midcell sites in an FtsZ-dependent manner and
CC       colocalizes with FtsZ. Localizes at septa, at poles and on membranes
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CrgA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00631}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK44236.1; -; Genomic_DNA.
DR   PIR; A70699; A70699.
DR   RefSeq; WP_003400344.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WP56; -.
DR   BMRB; P9WP56; -.
DR   SMR; P9WP56; -.
DR   EnsemblBacteria; AAK44236; AAK44236; MT0014.
DR   GeneID; 45423970; -.
DR   KEGG; mtc:MT0014; -.
DR   PATRIC; fig|83331.31.peg.15; -.
DR   HOGENOM; CLU_149126_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_00631; CrgA; 1.
DR   InterPro; IPR009619; CrgA.
DR   Pfam; PF06781; CrgA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Cell shape; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..93
FT                   /note="Cell division protein CrgA"
FT                   /id="PRO_0000427010"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00631"
FT   TOPO_DOM        52..69
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00631"
FT   TOPO_DOM        91..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   93 AA;  10430 MW;  3D656B59FF629690 CRC64;
     MPKSKVRKKN DFTVSAVSRT PMKVKVGPSS VWFVSLFIGL MLIGLIWLMV FQLAAIGSQA
     PTALNWMAQL GPWNYAIAFA FMITGLLLTM RWH