ID   CRGA_RAT                Reviewed;         174 AA.
AC   P10065;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Gamma-crystallin A;
DE   AltName: Full=Gamma-A-crystallin;
DE   AltName: Full=Gamma-crystallin 1-1;
GN   Name=Cryga;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3783678; DOI=10.1016/0022-2836(86)90379-7;
RA   den Dunnen J.T., Moormann R.J.M., Lubsen N.H., Schoenmakers J.G.G.;
RT   "Concerted and divergent evolution within the rat gamma-crystallin gene
RT   family.";
RL   J. Mol. Biol. 189:37-46(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2777080; DOI=10.1016/0378-1119(89)90223-0;
RA   den Dunnen J.T., van Neck J.W., Cremers F.P.M., Lubsen N.H.,
RA   Schoenmakers J.G.G.;
RT   "Nucleotide sequence of the rat gamma-crystallin gene region and comparison
RT   with an orthologous human region.";
RL   Gene 78:201-213(1989).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC       rat lens.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; M19359; AAA40981.1; -; Genomic_DNA.
DR   PIR; A24060; A24060.
DR   RefSeq; NP_001074405.1; NM_001080936.1.
DR   AlphaFoldDB; P10065; -.
DR   SMR; P10065; -.
DR   STRING; 10116.ENSRNOP00000019963; -.
DR   PaxDb; P10065; -.
DR   Ensembl; ENSRNOT00000019963; ENSRNOP00000019963; ENSRNOG00000046343.
DR   GeneID; 684028; -.
DR   KEGG; rno:684028; -.
DR   CTD; 1418; -.
DR   RGD; 1595217; Cryga.
DR   eggNOG; ENOG502RXJY; Eukaryota.
DR   GeneTree; ENSGT00940000156190; -.
DR   HOGENOM; CLU_081883_1_1_1; -.
DR   InParanoid; P10065; -.
DR   OMA; TEDCPCI; -.
DR   OrthoDB; 1220704at2759; -.
DR   PhylomeDB; P10065; -.
DR   PRO; PR:P10065; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000014790; Expressed in kidney and 7 other tissues.
DR   Genevisible; P10065; RN.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0001654; P:eye development; ISO:RGD.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEP:RGD.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   3: Inferred from homology;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..174
FT                   /note="Gamma-crystallin A"
FT                   /id="PRO_0000057589"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..128
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          129..171
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..87
FT                   /note="Connecting peptide"
FT   CONFLICT        16
FT                   /note="C -> S (in Ref. 1; no nucleotide entry)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   174 AA;  21094 MW;  17AA5EB5FA9AB6C0 CRC64;
     MGKITFYEDR GFQGRCYECS SDCPNLQTYF SRCNSIRVDS GCWMLYERPN YQGYQYFLRR
     GDYPDYQQWM GFSDSIRSCR SIPYTSSHRI RLYERDDYRG LVSELTEDCS CIHDRFRLNE
     IYSMHVLEGS WVLYEMPNYR GRQYLLRPGD YRRYHDWGAM DAKVGSLRRV MDLY