ID   CRGA_STRAW              Reviewed;          84 AA.
AC   Q93JL8;
DT   04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Cell division protein CrgA {ECO:0000255|HAMAP-Rule:MF_00631};
GN   Name=crgA {ECO:0000255|HAMAP-Rule:MF_00631}; Synonyms=whiP;
GN   OrderedLocusNames=SAV_4331;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RA   Pitman A., Herron P., Dyson P.;
RT   "Improved Tn1792 transposon mutagenesis resulting from cointegrate
RT   resolution in Streptomyces avermitilis.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
RN   [4]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=14594842; DOI=10.1128/jb.185.22.6678-6685.2003;
RA   Del Sol R., Pitman A., Herron P., Dyson P.;
RT   "The product of a developmental gene, crgA, that coordinates reproductive
RT   growth in Streptomyces belongs to a novel family of small actinomycete-
RT   specific proteins.";
RL   J. Bacteriol. 185:6678-6685(2003).
CC   -!- FUNCTION: Involved in cell division. Coordinates growth and cell
CC       division. Required for the formation of the sporulation septa.
CC       {ECO:0000255|HAMAP-Rule:MF_00631, ECO:0000269|PubMed:14594842}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00631};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00631}.
CC   -!- DISRUPTION PHENOTYPE: Inactivation of the gene abolishes most
CC       sporulation septation in aerial hyphae. {ECO:0000269|PubMed:14594842}.
CC   -!- SIMILARITY: Belongs to the CrgA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00631}.
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DR   EMBL; AJ320280; CAC47962.1; -; Genomic_DNA.
DR   EMBL; BA000030; BAC72043.1; -; Genomic_DNA.
DR   RefSeq; WP_010985756.1; NZ_JZJK01000079.1.
DR   AlphaFoldDB; Q93JL8; -.
DR   SMR; Q93JL8; -.
DR   STRING; 227882.SAV_4331; -.
DR   DNASU; 1210957; -.
DR   EnsemblBacteria; BAC72043; BAC72043; SAVERM_4331.
DR   KEGG; sma:SAVERM_4331; -.
DR   eggNOG; ENOG5032ZHR; Bacteria.
DR   HOGENOM; CLU_149126_1_0_11; -.
DR   OMA; WNIVVGF; -.
DR   OrthoDB; 2085550at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00631; CrgA; 1.
DR   InterPro; IPR009619; CrgA.
DR   Pfam; PF06781; CrgA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..84
FT                   /note="Cell division protein CrgA"
FT                   /id="PRO_0000216816"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00631"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00631"
SQ   SEQUENCE   84 AA;  9227 MW;  4141A1C777308091 CRC64;
     MPKSRIRKKA DYTPPPSKQA TNIKLGSRGW VAPVMLAMFL IGLAWIVVFY VTDGSLPIDA
     LDNWNIVVGF GFIAAGFGVS TQWK