ID   CRGA_STRCO              Reviewed;          84 AA.
AC   Q9XA10;
DT   04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Cell division protein CrgA {ECO:0000255|HAMAP-Rule:MF_00631};
GN   Name=crgA {ECO:0000255|HAMAP-Rule:MF_00631}; OrderedLocusNames=SCO3854;
GN   ORFNames=SCH69.24;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=14594842; DOI=10.1128/jb.185.22.6678-6685.2003;
RA   Del Sol R., Pitman A., Herron P., Dyson P.;
RT   "The product of a developmental gene, crgA, that coordinates reproductive
RT   growth in Streptomyces belongs to a novel family of small actinomycete-
RT   specific proteins.";
RL   J. Bacteriol. 185:6678-6685(2003).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, AND INDUCTION.
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=16452438; DOI=10.1128/jb.188.4.1540-1550.2006;
RA   Del Sol R., Mullins J.G., Grantcharova N., Flardh K., Dyson P.;
RT   "Influence of CrgA on assembly of the cell division protein FtsZ during
RT   development of Streptomyces coelicolor.";
RL   J. Bacteriol. 188:1540-1550(2006).
CC   -!- FUNCTION: Involved in cell division. Coordinates growth and cell
CC       division. May act as an inhibitor of Z-ring formation.
CC       {ECO:0000255|HAMAP-Rule:MF_00631, ECO:0000269|PubMed:14594842,
CC       ECO:0000269|PubMed:16452438}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00631,
CC       ECO:0000269|PubMed:16452438}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_00631, ECO:0000269|PubMed:16452438}.
CC       Note=Localizes at discrete foci distal from growing hyphal tips.
CC   -!- INDUCTION: Expression peaks immediately before the appearance of aerial
CC       hyphae. {ECO:0000269|PubMed:16452438}.
CC   -!- DISRUPTION PHENOTYPE: Disruption causes precocious erection of aerial
CC       hyphae and early antibiotic production on glucose-containing solid
CC       media. {ECO:0000269|PubMed:14594842}.
CC   -!- SIMILARITY: Belongs to the CrgA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00631}.
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DR   EMBL; AL939118; CAB45221.1; -; Genomic_DNA.
DR   PIR; T36723; T36723.
DR   RefSeq; NP_628042.1; NC_003888.3.
DR   RefSeq; WP_003975080.1; NZ_VNID01000003.1.
DR   AlphaFoldDB; Q9XA10; -.
DR   SMR; Q9XA10; -.
DR   STRING; 100226.SCO3854; -.
DR   GeneID; 1099290; -.
DR   KEGG; sco:SCO3854; -.
DR   PATRIC; fig|100226.15.peg.3925; -.
DR   eggNOG; ENOG5032ZHR; Bacteria.
DR   HOGENOM; CLU_149126_1_0_11; -.
DR   InParanoid; Q9XA10; -.
DR   OMA; WNIVVGF; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00631; CrgA; 1.
DR   InterPro; IPR009619; CrgA.
DR   Pfam; PF06781; CrgA; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..84
FT                   /note="Cell division protein CrgA"
FT                   /id="PRO_0000216817"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00631"
FT   TOPO_DOM        52..60
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00631"
FT   TOPO_DOM        82..84
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   84 AA;  9188 MW;  917161246A1F7F33 CRC64;
     MPKSRIRKKA DYTPPPSKQA TSIKLTSRGW VAPVMLAMFV IGLAWIVVFY VTDGSLPIDS
     LGNWNIVVGF GFIAAGFGVS TQWK