ID   CRGB_CANLF              Reviewed;         175 AA.
AC   A3RLE1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Gamma-crystallin B;
DE   AltName: Full=Gamma-B-crystallin;
GN   Name=CRYGB;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RT   "Dog gammaB-crystallin.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; EF426308; ABO14693.1; -; mRNA.
DR   RefSeq; NP_001104269.1; NM_001110799.1.
DR   AlphaFoldDB; A3RLE1; -.
DR   SMR; A3RLE1; -.
DR   STRING; 9615.ENSCAFP00000052047; -.
DR   PaxDb; A3RLE1; -.
DR   Ensembl; ENSCAFT00030020950; ENSCAFP00030018273; ENSCAFG00030011216.
DR   Ensembl; ENSCAFT00040048307; ENSCAFP00040042190; ENSCAFG00040025842.
DR   Ensembl; ENSCAFT00845040802; ENSCAFP00845031945; ENSCAFG00845023028.
DR   GeneID; 488497; -.
DR   KEGG; cfa:488497; -.
DR   CTD; 1419; -.
DR   VEuPathDB; HostDB:ENSCAFG00845023028; -.
DR   eggNOG; ENOG502RXJY; Eukaryota.
DR   GeneTree; ENSGT00940000159232; -.
DR   HOGENOM; CLU_081883_1_1_1; -.
DR   InParanoid; A3RLE1; -.
DR   OMA; PPHTGAY; -.
DR   OrthoDB; 1220704at2759; -.
DR   Proteomes; UP000002254; Chromosome 37.
DR   Bgee; ENSCAFG00000032653; Expressed in spinal cord and 5 other tissues.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..175
FT                   /note="Gamma-crystallin B"
FT                   /id="PRO_0000289594"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          89..129
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          130..172
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..88
FT                   /note="Connecting peptide"
SQ   SEQUENCE   175 AA;  21102 MW;  C67C0AEC3D548988 CRC64;
     MGKITFYEDR GFQGRCYECS SDCPNLQPYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR
     GDYPDYQQWL GFSDSIRSCR LIPQHSGTFR MRIYERDDFR GQMSEITDDC LSLQDRFHLN
     EIHSLNVLDG CWVLYEMPSY RGRQYLLRPG EYRRYLDWGA MNAKVGSLRR VMDFY