CRGB_MOUSE
ID CRGB_MOUSE Reviewed; 175 AA.
AC P04344; Q61593; Q6PHP7;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 4.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Gamma-crystallin B;
DE AltName: Full=Gamma-B-crystallin;
DE AltName: Full=Gamma-crystallin 3;
GN Name=Crygb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=102 X C3H; TISSUE=Liver;
RX PubMed=8293998; DOI=10.1016/0378-1119(93)90458-f;
RA Graw J., Liebstein A., Pietrowski D., Schmitt-John T., Werner T.;
RT "Genomic sequences of murine gamma B- and gamma C-crystallin-encoding
RT genes: promoter analysis and complete evolutionary pattern of mouse, rat
RT and human gamma-crystallins.";
RL Gene 136:145-156(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lens;
RA Wistow G.;
RT "Mouse gammaB-crystallin.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 38-175.
RX PubMed=6096855; DOI=10.1073/pnas.81.24.7762;
RA Breitman M.L., Lok S., Wistow G., Piatigorsky J., Treton J.A., Gold R.J.M.,
RA Tsui L.-C.;
RT "Gamma-crystallin family of the mouse lens: structural and evolutionary
RT relationships.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:7762-7766(1984).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC mouse lens.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; Z22573; CAA80296.1; -; Genomic_DNA.
DR EMBL; EF426303; ABO14688.1; -; mRNA.
DR EMBL; AK143110; BAE25271.1; -; mRNA.
DR EMBL; AC101869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC158958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC056455; AAH56455.1; -; mRNA.
DR EMBL; K02585; AAA37474.1; -; mRNA.
DR CCDS; CCDS15013.1; -.
DR PIR; I48359; CYMSG3.
DR RefSeq; NP_658906.1; NM_144761.2.
DR AlphaFoldDB; P04344; -.
DR SMR; P04344; -.
DR STRING; 10090.ENSMUSP00000027090; -.
DR iPTMnet; P04344; -.
DR PhosphoSitePlus; P04344; -.
DR PaxDb; P04344; -.
DR PRIDE; P04344; -.
DR ProteomicsDB; 284012; -.
DR Antibodypedia; 34195; 67 antibodies from 16 providers.
DR DNASU; 12965; -.
DR Ensembl; ENSMUST00000027090; ENSMUSP00000027090; ENSMUSG00000073658.
DR GeneID; 12965; -.
DR KEGG; mmu:12965; -.
DR UCSC; uc007bhj.2; mouse.
DR CTD; 1419; -.
DR MGI; MGI:88522; Crygb.
DR VEuPathDB; HostDB:ENSMUSG00000073658; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000159232; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; P04344; -.
DR OMA; AYRMKIY; -.
DR OrthoDB; 1220704at2759; -.
DR PhylomeDB; P04344; -.
DR BioGRID-ORCS; 12965; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Crygb; mouse.
DR PRO; PR:P04344; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P04344; protein.
DR Bgee; ENSMUSG00000073658; Expressed in lens of camera-type eye and 37 other tissues.
DR Genevisible; P04344; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005212; F:structural constituent of eye lens; IDA:MGI.
DR GO; GO:0001654; P:eye development; IMP:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
DR GO; GO:0070307; P:lens fiber cell development; IMP:MGI.
DR GO; GO:0070309; P:lens fiber cell morphogenesis; IMP:MGI.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..175
FT /note="Gamma-crystallin B"
FT /id="PRO_0000057596"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 89..129
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 130..172
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..88
FT /note="Connecting peptide"
FT CONFLICT 80
FT /note="C -> R (in Ref. 1; CAA80296 and 6; AAA37474)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="E -> M (in Ref. 6; AAA37474)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 175 AA; 21086 MW; 1E39B15A0AAB175D CRC64;
MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN YQGHQYFLRR
GEYPDYQQWM GFSDSIRSCC LIPQHSGTYR MRIYEKDDFR GQMSEITDDC LSLQDRFHFS
EIHSLNVMEG CWVLYEMPSY RGRQYLLRPG EYRRYLDWGA ANAKVGSFRR VMDFY
