CRGC_BOVIN
ID CRGC_BOVIN Reviewed; 174 AA.
AC Q28088; A3RLE3;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Gamma-crystallin C;
DE AltName: Full=Gamma-C-crystallin;
DE AltName: Full=Gamma-crystallin IIIA;
GN Name=CRYGC;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Lens;
RX PubMed=7925695; DOI=10.1006/exer.1994.1052;
RA Hay R.E., Andley U.P., Petrash J.M.;
RT "Expression of recombinant bovine gamma B-, gamma C- and gamma D-
RT crystallins and correlation with native proteins.";
RL Exp. Eye Res. 58:573-584(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lens;
RA Wistow G.;
RT "Cow gammaC-crystallin.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; L27069; AAB59263.1; -; mRNA.
DR EMBL; EF426310; ABO14695.1; -; mRNA.
DR PIR; I45881; I45881.
DR RefSeq; NP_001013613.1; NM_001013595.1.
DR AlphaFoldDB; Q28088; -.
DR SMR; Q28088; -.
DR BioGRID; 159038; 3.
DR STRING; 9913.ENSBTAP00000019664; -.
DR PaxDb; Q28088; -.
DR PRIDE; Q28088; -.
DR Ensembl; ENSBTAT00000019664; ENSBTAP00000019664; ENSBTAG00000014783.
DR GeneID; 281722; -.
DR KEGG; bta:281722; -.
DR CTD; 1420; -.
DR VEuPathDB; HostDB:ENSBTAG00000014783; -.
DR VGNC; VGNC:27741; CRYGC.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000159232; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; Q28088; -.
DR OMA; YEMPNYL; -.
DR OrthoDB; 1220704at2759; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000014783; Expressed in cumulus cell and 1 other tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Eye lens protein; Methylation;
KW Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin C"
FT /id="PRO_0000057583"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT MOD_RES 23
FT /note="S-methylcysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 174 AA; 20874 MW; 24146C987A34A31E CRC64;
MGKITFYEDR GFQGRCYQCS SDCPNLQPYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR
GDYPDYQQWM GFNDSIRSCC LISDTSSHRL RLYEREDQKG LIAELSEDCP CIQDRFRLSE
VRSLHVLEGC WVLYEMPNYR GRQYLLRPQE YRRYQDWGAV DAKAGSLRRV VDLY
