ID   CRGC_CANLF              Reviewed;         174 AA.
AC   A3RLE2;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Gamma-crystallin C;
DE   AltName: Full=Gamma-C-crystallin;
GN   Name=CRYGC;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Wistow G.;
RT   "Dog gammaC-crystallin.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; EF426309; ABO14694.1; -; mRNA.
DR   RefSeq; NP_001076069.1; NM_001082600.1.
DR   AlphaFoldDB; A3RLE2; -.
DR   SMR; A3RLE2; -.
DR   STRING; 9612.ENSCAFP00000037656; -.
DR   PaxDb; A3RLE2; -.
DR   Ensembl; ENSCAFT00030020807; ENSCAFP00030018149; ENSCAFG00030011216.
DR   Ensembl; ENSCAFT00040048300; ENSCAFP00040042184; ENSCAFG00040025842.
DR   GeneID; 100126770; -.
DR   CTD; 1420; -.
DR   eggNOG; ENOG502RXJY; Eukaryota.
DR   HOGENOM; CLU_081883_1_1_1; -.
DR   InParanoid; A3RLE2; -.
DR   OMA; YEMPNYL; -.
DR   Proteomes; UP000002254; Unplaced.
DR   Bgee; ENSCAFG00000013590; Expressed in occipital cortex and 28 other tissues.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Methylation; Reference proteome; Repeat.
FT   CHAIN           1..174
FT                   /note="Gamma-crystallin C"
FT                   /id="PRO_0000289595"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..128
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          129..171
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..87
FT                   /note="Connecting peptide"
FT   MOD_RES         23
FT                   /note="S-methylcysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   174 AA;  20898 MW;  EE54C71A660B46BF CRC64;
     MGKITFYEDR GFQGRHYECS SDCPNLQPYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR
     GDYPDYQQWL GFSDSIRSCC LIPQTSSHRL RLYEREDHKG LMVELSEDCS CIQDRFHLSE
     VRSVHVLEGC WVLYEMPNYL GRQYLLRPQE YRRYHDWGAM DAKAGSLRRV VDLY