CRGC_HUMAN
ID CRGC_HUMAN Reviewed; 174 AA.
AC P07315; Q53R50;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 198.
DE RecName: Full=Gamma-crystallin C;
DE AltName: Full=Gamma-C-crystallin;
DE AltName: Full=Gamma-crystallin 2-1;
DE AltName: Full=Gamma-crystallin 3;
GN Name=CRYGC; Synonyms=CRYG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=4065573; DOI=10.1016/0378-1119(85)90218-5;
RA den Dunnen J.T., Moormann R.J.M., Cremers F.P.M., Schoenmakers J.G.G.;
RT "Two human gamma-crystallin genes are linked and riddled with Alu-
RT repeats.";
RL Gene 38:197-204(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=4033658; DOI=10.1128/mcb.5.6.1408-1414.1985;
RA Meakin S.O., Breitman M.L., Tsui L.-C.;
RT "Structural and evolutionary relationships among five members of the human
RT gamma-crystallin gene family.";
RL Mol. Cell. Biol. 5:1408-1414(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2777080; DOI=10.1016/0378-1119(89)90223-0;
RA den Dunnen J.T., van Neck J.W., Cremers F.P.M., Lubsen N.H.,
RA Schoenmakers J.G.G.;
RT "Nucleotide sequence of the rat gamma-crystallin gene region and comparison
RT with an orthologous human region.";
RL Gene 78:201-213(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lens;
RA Petrash J.M., Mathur S., Manoharan M., Andley U.P.;
RT "Cloning and expression of human lens crystallins.";
RL Invest. Ophthalmol. Vis. Sci. 36:S882-S882(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 2-26.
RX PubMed=8999933; DOI=10.1074/jbc.272.4.2268;
RA Lampi K.J., Ma Z., Shih M., Shearer T.R., Smith J.B., Smith D.L.,
RA David L.L.;
RT "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the
RT identification of the major proteins in young human lens.";
RL J. Biol. Chem. 272:2268-2275(1997).
RN [9]
RP METHYLATION AT CYS-23, AND MASS SPECTROMETRY.
RX PubMed=12876325; DOI=10.1110/ps.0305403;
RA Lapko V.N., Smith D.L., Smith J.B.;
RT "Methylation and carbamylation of human gamma-crystallins.";
RL Protein Sci. 12:1762-1774(2003).
RN [10]
RP INVOLVEMENT IN CTRCT2.
RX PubMed=22876111;
RA Guo Y., Su D., Li Q., Yang Z., Ma Z., Ma X., Zhu S.;
RT "A nonsense mutation of CRYGC associated with autosomal dominant congenital
RT nuclear cataracts and microcornea in a Chinese pedigree.";
RL Mol. Vis. 18:1874-1880(2012).
RN [11]
RP 3D-STRUCTURE MODELING.
RX PubMed=12507494; DOI=10.1016/s0006-291x(02)02895-4;
RA Salim A., Zaidi Z.H.;
RT "Homology models of human gamma-crystallins: structural study of the
RT extensive charge network in gamma-crystallins.";
RL Biochem. Biophys. Res. Commun. 300:624-630(2003).
RN [12]
RP VARIANT CTRCT2 PRO-5.
RX PubMed=10521291; DOI=10.1086/302619;
RA Heon E., Priston M., Schorderet D.F., Billingsley G.D., Girard P.O.,
RA Lubsen N., Munier F.L.;
RT "The gamma-crystallins and human cataracts: a puzzle made clearer.";
RL Am. J. Hum. Genet. 65:1261-1267(1999).
RN [13]
RP ERRATUM OF PUBMED:10521291.
RA Heon E., Priston M., Schorderet D.F., Billingsley G.D., Girard P.O.,
RA Lubsen N., Munier F.L.;
RL Am. J. Hum. Genet. 66:753-753(2000).
RN [14]
RP INVOLVEMENT IN CTRCT2.
RX PubMed=10914683; DOI=10.1007/s004390000289;
RA Ren Z., Li A., Shastry B.S., Padma T., Ayyagari R., Scott M.H., Parks M.M.,
RA Kaiser-Kupfer M.I., Hejtmancik J.F.;
RT "A 5-base insertion in the gammaC-crystallin gene is associated with
RT autosomal dominant variable zonular pulverulent cataract.";
RL Hum. Genet. 106:531-537(2000).
RN [15]
RP VARIANT CTRCT2 TRP-168, AND VARIANT HIS-48.
RX PubMed=12011157; DOI=10.1136/jmg.39.5.352;
RA Santhiya S.T., Shyam Manohar M., Rawlley D., Vijayalakshmi P.,
RA Namperumalsamy P., Gopinath P.M., Loester J., Graw J.;
RT "Novel mutations in the gamma-crystallin genes cause autosomal dominant
RT congenital cataracts.";
RL J. Med. Genet. 39:352-358(2002).
RN [16]
RP CHARACTERIZATION OF VARIANT CTRCT2 PRO-5.
RX PubMed=12601044; DOI=10.1167/iovs.02-0950;
RA Fu L., Liang J.J.-N.;
RT "Alteration of protein-protein interactions of congenital cataract
RT crystallin mutants.";
RL Invest. Ophthalmol. Vis. Sci. 44:1155-1159(2003).
RN [17]
RP VARIANT CTRCT2 TRP-168.
RX PubMed=18587492;
RA Devi R.R., Yao W., Vijayalakshmi P., Sergeev Y.V., Sundaresan P.,
RA Hejtmancik J.F.;
RT "Crystallin gene mutations in Indian families with inherited pediatric
RT cataract.";
RL Mol. Vis. 14:1157-1170(2008).
RN [18]
RP VARIANT HIS-48.
RX PubMed=21423869;
RA Kumar M., Agarwal T., Khokhar S., Kumar M., Kaur P., Roy T.S., Dada R.;
RT "Mutation screening and genotype phenotype correlation of alpha-crystallin,
RT gamma-crystallin and GJA8 gene in congenital cataract.";
RL Mol. Vis. 17:693-707(2011).
RN [19]
RP VARIANT CTRCT2 CYS-129.
RX PubMed=22052681; DOI=10.1002/humu.21648;
RA Li X.Q., Cai H.C., Zhou S.Y., Yang J.H., Xi Y.B., Gao X.B., Zhao W.J.,
RA Li P., Zhao G.Y., Tong Y., Bao F.C., Ma Y., Wang S., Yan Y.B., Lu C.L.,
RA Ma X.;
RT "A novel mutation impairing the tertiary structure and stability of gammaC-
RT crystallin (CRYGC) leads to cataract formation in humans and zebrafish
RT lens.";
RL Hum. Mutat. 33:391-401(2012).
RN [20]
RP VARIANTS CTRCT2 HIS-48 AND 144-TYR--TYR-174 DEL.
RX PubMed=29386872;
RA Sun Z., Zhou Q., Li H., Yang L., Wu S., Sui R.;
RT "Mutations in crystallin genes result in congenital cataract associated
RT with other ocular abnormalities.";
RL Mol. Vis. 23:977-986(2017).
RN [21]
RP VARIANT CTRCT2 PHE-78.
RX PubMed=29914532; DOI=10.1186/s13023-018-0828-0;
RA Li J., Leng Y., Han S., Yan L., Lu C., Luo Y., Zhang X., Cao L.;
RT "Clinical and genetic characteristics of Chinese patients with familial or
RT sporadic pediatric cataract.";
RL Orphanet J. Rare Dis. 13:94-94(2018).
RN [22]
RP VARIANT CTRCT2 PRO-5.
RX PubMed=33243271; DOI=10.1186/s13023-020-01613-3;
RA Berry V., Ionides A., Pontikos N., Georgiou M., Yu J., Ocaka L.A.,
RA Moore A.T., Quinlan R.A., Michaelides M.;
RT "The genetic landscape of crystallins in congenital cataract.";
RL Orphanet J. Rare Dis. 15:333-333(2020).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- INTERACTION:
CC P07315; P02489: CRYAA; NbExp=3; IntAct=EBI-6875941, EBI-6875961;
CC P07315; P02511: CRYAB; NbExp=3; IntAct=EBI-6875941, EBI-739060;
CC P07315; Q9C029: TRIM7; NbExp=3; IntAct=EBI-6875941, EBI-2813981;
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- MASS SPECTROMETRY: Mass=20747; Mass_error=0.2; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:12876325};
CC -!- DISEASE: Cataract 2, multiple types (CTRCT2) [MIM:604307]: An
CC opacification of the crystalline lens of the eye that frequently
CC results in visual impairment or blindness. Opacities vary in
CC morphology, are often confined to a portion of the lens, and may be
CC static or progressive. CTRCT2 includes Coppock-like cataract, among
CC others. Coppock-like cataract is a congenital pulverulent disk-like
CC opacity involving the embryonic nucleus with many tiny white dots in
CC the lamellar portion of the lens. It is usually bilateral and
CC dominantly inherited. In some cases, CTRCT2 is associated with
CC microcornea without any other systemic anomaly or dysmorphism.
CC Microcornea is defined by a corneal diameter inferior to 10 mm in both
CC meridians in an otherwise normal eye. {ECO:0000269|PubMed:10521291,
CC ECO:0000269|PubMed:10914683, ECO:0000269|PubMed:12011157,
CC ECO:0000269|PubMed:12601044, ECO:0000269|PubMed:18587492,
CC ECO:0000269|PubMed:22052681, ECO:0000269|PubMed:22876111,
CC ECO:0000269|PubMed:29386872, ECO:0000269|PubMed:29914532,
CC ECO:0000269|PubMed:33243271}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Eye disease Crystallin, gamma-C (CRYGC); Note=Leiden
CC Open Variation Database (LOVD);
CC URL="https://databases.lovd.nl/shared/genes/CRYGC";
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DR EMBL; M11973; AAA52114.1; -; Genomic_DNA.
DR EMBL; M11972; AAA52114.1; JOINED; Genomic_DNA.
DR EMBL; K03004; AAA52111.1; -; Genomic_DNA.
DR EMBL; K03003; AAA52111.1; JOINED; Genomic_DNA.
DR EMBL; M19364; AAA52110.1; -; Genomic_DNA.
DR EMBL; U66582; AAC50899.1; -; mRNA.
DR EMBL; AC093698; AAY24042.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70433.1; -; Genomic_DNA.
DR EMBL; BC074954; AAH74954.1; -; mRNA.
DR EMBL; BC074955; AAH74955.1; -; mRNA.
DR CCDS; CCDS2379.1; -.
DR PIR; B24520; CYHUG2.
DR RefSeq; NP_066269.1; NM_020989.3.
DR RefSeq; XP_011508964.1; XM_011510662.1.
DR PDB; 2NBR; NMR; -; A=2-174.
DR PDBsum; 2NBR; -.
DR AlphaFoldDB; P07315; -.
DR SMR; P07315; -.
DR BioGRID; 107810; 36.
DR IntAct; P07315; 6.
DR MINT; P07315; -.
DR STRING; 9606.ENSP00000282141; -.
DR ChEMBL; CHEMBL4296285; -.
DR iPTMnet; P07315; -.
DR PhosphoSitePlus; P07315; -.
DR BioMuta; CRYGC; -.
DR DMDM; 117464; -.
DR MassIVE; P07315; -.
DR PaxDb; P07315; -.
DR PeptideAtlas; P07315; -.
DR PRIDE; P07315; -.
DR ProteomicsDB; 51985; -.
DR Antibodypedia; 34194; 176 antibodies from 27 providers.
DR DNASU; 1420; -.
DR Ensembl; ENST00000282141.4; ENSP00000282141.3; ENSG00000163254.5.
DR Ensembl; ENST00000646204.2; ENSP00000496418.1; ENSG00000285011.2.
DR GeneID; 1420; -.
DR KEGG; hsa:1420; -.
DR MANE-Select; ENST00000282141.4; ENSP00000282141.3; NM_020989.4; NP_066269.1.
DR UCSC; uc002vco.4; human.
DR CTD; 1420; -.
DR DisGeNET; 1420; -.
DR GeneCards; CRYGC; -.
DR HGNC; HGNC:2410; CRYGC.
DR HPA; ENSG00000163254; Tissue enriched (testis).
DR MalaCards; CRYGC; -.
DR MIM; 123680; gene.
DR MIM; 604307; phenotype.
DR neXtProt; NX_P07315; -.
DR OpenTargets; ENSG00000163254; -.
DR Orphanet; 1377; Cataract-microcornea syndrome.
DR Orphanet; 441452; Early-onset lamellar cataract.
DR Orphanet; 98991; Early-onset nuclear cataract.
DR Orphanet; 98984; Pulverulent cataract.
DR PharmGKB; PA26917; -.
DR VEuPathDB; HostDB:ENSG00000163254; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000159232; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; P07315; -.
DR OMA; YEREEYK; -.
DR OrthoDB; 1220704at2759; -.
DR PhylomeDB; P07315; -.
DR PathwayCommons; P07315; -.
DR SignaLink; P07315; -.
DR SIGNOR; P07315; -.
DR BioGRID-ORCS; 1420; 16 hits in 1072 CRISPR screens.
DR GeneWiki; CRYGC; -.
DR GenomeRNAi; 1420; -.
DR Pharos; P07315; Tbio.
DR PRO; PR:P07315; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P07315; protein.
DR Bgee; ENSG00000163254; Expressed in testis and 8 other tissues.
DR ExpressionAtlas; P07315; baseline and differential.
DR Genevisible; P07315; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IMP:UniProtKB.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Cataract; Direct protein sequencing; Disease variant;
KW Eye lens protein; Methylation; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8999933"
FT CHAIN 2..174
FT /note="Gamma-crystallin C"
FT /id="PRO_0000057587"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT MOD_RES 23
FT /note="S-methylcysteine"
FT /evidence="ECO:0000269|PubMed:12876325"
FT VARIANT 5
FT /note="T -> P (in CTRCT2; reduces protein-protein
FT interactions in vivo; dbSNP:rs104893618)"
FT /evidence="ECO:0000269|PubMed:10521291,
FT ECO:0000269|PubMed:12601044, ECO:0000269|PubMed:33243271"
FT /id="VAR_021142"
FT VARIANT 6
FT /note="F -> L (in dbSNP:rs2242072)"
FT /id="VAR_038432"
FT VARIANT 48
FT /note="R -> H (in dbSNP:rs61751949)"
FT /evidence="ECO:0000269|PubMed:12011157,
FT ECO:0000269|PubMed:21423869, ECO:0000269|PubMed:29386872"
FT /id="VAR_021143"
FT VARIANT 78
FT /note="S -> F (in CTRCT2; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:29914532"
FT /id="VAR_084798"
FT VARIANT 129
FT /note="G -> C (in CTRCT2; dbSNP:rs137853924)"
FT /evidence="ECO:0000269|PubMed:22052681"
FT /id="VAR_067212"
FT VARIANT 144..174
FT /note="Missing (in CTRCT2; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:29386872"
FT /id="VAR_084799"
FT VARIANT 168
FT /note="R -> W (in CTRCT2; congenital lamellar cataract;
FT unknown pathological significance; dbSNP:rs28931604)"
FT /evidence="ECO:0000269|PubMed:12011157,
FT ECO:0000269|PubMed:18587492"
FT /id="VAR_021144"
FT STRAND 4..9
FT /evidence="ECO:0007829|PDB:2NBR"
FT TURN 10..12
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 13..21
FT /evidence="ECO:0007829|PDB:2NBR"
FT TURN 27..29
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 34..38
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 40..48
FT /evidence="ECO:0007829|PDB:2NBR"
FT TURN 49..51
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 52..58
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 60..65
FT /evidence="ECO:0007829|PDB:2NBR"
FT HELIX 66..69
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 78..82
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 89..95
FT /evidence="ECO:0007829|PDB:2NBR"
FT TURN 96..98
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 99..105
FT /evidence="ECO:0007829|PDB:2NBR"
FT HELIX 112..115
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 122..129
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 131..136
FT /evidence="ECO:0007829|PDB:2NBR"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 140..146
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 148..151
FT /evidence="ECO:0007829|PDB:2NBR"
FT TURN 154..158
FT /evidence="ECO:0007829|PDB:2NBR"
FT STRAND 165..169
FT /evidence="ECO:0007829|PDB:2NBR"
SQ SEQUENCE 174 AA; 20879 MW; B01DC167171A7668 CRC64;
MGKITFYEDR AFQGRSYETT TDCPNLQPYF SRCNSIRVES GCWMLYERPN YQGQQYLLRR
GEYPDYQQWM GLSDSIRSCC LIPQTVSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE
IRSLHVLEGC WVLYELPNYR GRQYLLRPQE YRRCQDWGAM DAKAGSLRRV VDLY
