CRGC_MACMU
ID CRGC_MACMU Reviewed; 174 AA.
AC A3RLD8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Gamma-crystallin C;
DE AltName: Full=Gamma-C-crystallin;
GN Name=CRYGC;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lens;
RA Wistow G.;
RT "Rhesus monkey gammaC-crystallin.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; EF426305; ABO14690.1; -; mRNA.
DR RefSeq; NP_001076433.1; NM_001082964.1.
DR AlphaFoldDB; A3RLD8; -.
DR SMR; A3RLD8; -.
DR STRING; 9544.ENSMMUP00000015388; -.
DR Ensembl; ENSMMUT00000087819; ENSMMUP00000070892; ENSMMUG00000056938.
DR GeneID; 709553; -.
DR KEGG; mcc:709553; -.
DR CTD; 1420; -.
DR VEuPathDB; HostDB:ENSMMUG00000056938; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000159232; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; A3RLD8; -.
DR OMA; YEREEYK; -.
DR Proteomes; UP000006718; Chromosome 12.
DR Bgee; ENSMMUG00000056938; Expressed in liver and 2 other tissues.
DR ExpressionAtlas; A3RLD8; baseline.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Methylation; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin C"
FT /id="PRO_0000289609"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT MOD_RES 23
FT /note="S-methylcysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 174 AA; 20730 MW; 4D50B9AE32B09CC5 CRC64;
MGKITLYEDK AFQGRSYEST TDCPNLQTYL SRCNSIRVES GCWMLYERPN YQGQQYLLRR
GEYPDYQQWM GLSDSIRSCC LIPQTGSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE
IRSLHVLEGC WVLYELPNYR GRQYLLRPQE YRRCQDWGAM DAKAGSLRRV VDLY