CRGC_MOUSE
ID CRGC_MOUSE Reviewed; 174 AA.
AC Q61597; Q03739;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Gamma-crystallin C;
DE AltName: Full=Gamma-C-crystallin;
GN Name=Crygc; Synonyms=Gammab-cry;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=102 X C3H; TISSUE=Liver;
RX PubMed=8293998; DOI=10.1016/0378-1119(93)90458-f;
RA Graw J., Liebstein A., Pietrowski D., Schmitt-John T., Werner T.;
RT "Genomic sequences of murine gamma B- and gamma C-crystallin-encoding
RT genes: promoter analysis and complete evolutionary pattern of mouse, rat
RT and human gamma-crystallins.";
RL Gene 136:145-156(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 8-158.
RC STRAIN=CD-1; TISSUE=Eye;
RX PubMed=1623964; DOI=10.1016/0014-4835(92)90034-p;
RA Goring D.R., Breitman M.L., Tsui L.-C.;
RT "Temporal regulation of six crystallin transcripts during mouse lens
RT development.";
RL Exp. Eye Res. 54:785-795(1992).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC mouse lens.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; Z22574; CAA80297.1; -; Genomic_DNA.
DR EMBL; BC056454; AAH56454.1; -; mRNA.
DR EMBL; M64544; AAA53524.1; -; mRNA.
DR CCDS; CCDS15012.1; -.
DR PIR; I48360; S33526.
DR PIR; I49614; I49614.
DR RefSeq; NP_031801.1; NM_007775.2.
DR PDB; 2V2U; X-ray; 1.90 A; A/B=2-174.
DR PDBsum; 2V2U; -.
DR AlphaFoldDB; Q61597; -.
DR SMR; Q61597; -.
DR STRING; 10090.ENSMUSP00000109698; -.
DR PhosphoSitePlus; Q61597; -.
DR PaxDb; Q61597; -.
DR PRIDE; Q61597; -.
DR ProteomicsDB; 284168; -.
DR Antibodypedia; 34194; 176 antibodies from 27 providers.
DR DNASU; 12966; -.
DR Ensembl; ENSMUST00000027089; ENSMUSP00000027089; ENSMUSG00000025952.
DR GeneID; 12966; -.
DR KEGG; mmu:12966; -.
DR UCSC; uc007bhi.2; mouse.
DR CTD; 1420; -.
DR MGI; MGI:88523; Crygc.
DR VEuPathDB; HostDB:ENSMUSG00000025952; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000159232; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; Q61597; -.
DR BioGRID-ORCS; 12966; 1 hit in 72 CRISPR screens.
DR EvolutionaryTrace; Q61597; -.
DR PRO; PR:Q61597; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q61597; protein.
DR Bgee; ENSMUSG00000025952; Expressed in lens of camera-type eye and 45 other tissues.
DR ExpressionAtlas; Q61597; baseline and differential.
DR Genevisible; Q61597; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0043010; P:camera-type eye development; IMP:MGI.
DR GO; GO:0001654; P:eye development; IMP:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; ISO:MGI.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Eye lens protein; Methylation; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin C"
FT /id="PRO_0000057597"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT MOD_RES 23
FT /note="S-methylcysteine"
FT /evidence="ECO:0000250"
FT VARIANT 11
FT /note="S -> G (in strain: CD-1)"
FT VARIANT 14
FT /note="G -> A (in strain: CD-1)"
FT VARIANT 154..155
FT /note="FQ -> YH (in strain: CD-1)"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:2V2U"
FT TURN 10..12
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 13..21
FT /evidence="ECO:0007829|PDB:2V2U"
FT TURN 27..29
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 35..48
FT /evidence="ECO:0007829|PDB:2V2U"
FT TURN 49..51
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 52..58
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 60..65
FT /evidence="ECO:0007829|PDB:2V2U"
FT HELIX 66..69
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 78..82
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 89..95
FT /evidence="ECO:0007829|PDB:2V2U"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 99..107
FT /evidence="ECO:0007829|PDB:2V2U"
FT HELIX 112..115
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 123..129
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 131..136
FT /evidence="ECO:0007829|PDB:2V2U"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 140..146
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 148..153
FT /evidence="ECO:0007829|PDB:2V2U"
FT HELIX 154..156
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 160..163
FT /evidence="ECO:0007829|PDB:2V2U"
FT STRAND 166..169
FT /evidence="ECO:0007829|PDB:2V2U"
SQ SEQUENCE 174 AA; 20917 MW; ECEF819F051D431D CRC64;
MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN YQGHQYFLRR
GEYPDYQQWM GFSDSIRSCR LIPHAGSHRM RLYEKEDHKG VMMELSEDCS CIQDRFHLSE
VRSLQVLEGC WVLYEMPNYR GRQYLLRPQE YRRFQDWGSV DAKAGSLRRV VDLY
