CRGC_RAT
ID CRGC_RAT Reviewed; 174 AA.
AC P02529;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=Gamma-crystallin C;
DE AltName: Full=Gamma-C-crystallin;
DE AltName: Full=Gamma-crystallin 2-1;
GN Name=Crygc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=3783678; DOI=10.1016/0022-2836(86)90379-7;
RA den Dunnen J.T., Moormann R.J.M., Lubsen N.H., Schoenmakers J.G.G.;
RT "Concerted and divergent evolution within the rat gamma-crystallin gene
RT family.";
RL J. Mol. Biol. 189:37-46(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2777080; DOI=10.1016/0378-1119(89)90223-0;
RA den Dunnen J.T., van Neck J.W., Cremers F.P.M., Lubsen N.H.,
RA Schoenmakers J.G.G.;
RT "Nucleotide sequence of the rat gamma-crystallin gene region and comparison
RT with an orthologous human region.";
RL Gene 78:201-213(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-174.
RX PubMed=6294661; DOI=10.1073/pnas.79.22.6876;
RA Moormann R.J.M., den Dunnen J.T., Bloemendal H., Schoenmakers J.G.G.;
RT "Extensive intragenic sequence homology in two distinct rat lens gamma-
RT crystallin cDNAs suggests duplications of a primordial gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:6876-6880(1982).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC rat lens.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; M19359; AAA40983.1; -; Genomic_DNA.
DR EMBL; J00717; AAA40986.1; -; mRNA.
DR PIR; A02934; CYRTG2.
DR PIR; C24060; C24060.
DR PIR; I83432; I83432.
DR RefSeq; NP_001075129.1; NM_001081660.1.
DR AlphaFoldDB; P02529; -.
DR SMR; P02529; -.
DR STRING; 10116.ENSRNOP00000020078; -.
DR iPTMnet; P02529; -.
DR PhosphoSitePlus; P02529; -.
DR PaxDb; P02529; -.
DR GeneID; 24277; -.
DR KEGG; rno:24277; -.
DR UCSC; RGD:2421; rat.
DR CTD; 1420; -.
DR RGD; 2421; Crygc.
DR InParanoid; P02529; -.
DR OrthoDB; 1220704at2759; -.
DR PhylomeDB; P02529; -.
DR PRO; PR:P02529; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR GO; GO:0001654; P:eye development; ISO:RGD.
DR GO; GO:0002088; P:lens development in camera-type eye; IEP:RGD.
DR GO; GO:0007601; P:visual perception; ISO:RGD.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Methylation; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin C"
FT /id="PRO_0000057591"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT MOD_RES 23
FT /note="S-methylcysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 16
FT /note="C -> S (in Ref. 1; no nucleotide entry and 3;
FT AAA40986)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="I -> V (in Ref. 1; no nucleotide entry and 3;
FT AAA40986)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="H -> R (in Ref. 3; AAA40986)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="H -> Q (in Ref. 3; AAA40986)"
FT /evidence="ECO:0000305"
FT CONFLICT 169..170
FT /note="RV -> SA (in Ref. 3; AAA40986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 174 AA; 20951 MW; ADB5D16DF57BC13B CRC64;
MGKITFYEDR GFQGRCYECS SDCPNLQTYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR
GDYPDYQQWM GFSDSIRSCR LIPHTGSHRM RLYEKEDHKG VMMELSEDCS CIQDRFHLSE
VRSLHVLEGC WVLYEMPNYR GRQYLLRPQE YRRYHDWGAV DAKAGSLRRV VDLY
