CRGD_BOVIN
ID CRGD_BOVIN Reviewed; 174 AA.
AC P08209; Q28089;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=Gamma-crystallin D;
DE AltName: Full=Gamma-D-crystallin;
DE AltName: Full=Gamma-crystallin IIIB;
GN Name=CRYGD;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Lens;
RX PubMed=7925695; DOI=10.1006/exer.1994.1052;
RA Hay R.E., Andley U.P., Petrash J.M.;
RT "Expression of recombinant bovine gamma B-, gamma C- and gamma D-
RT crystallins and correlation with native proteins.";
RL Exp. Eye Res. 58:573-584(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-157.
RC TISSUE=Lens;
RX PubMed=3606621; DOI=10.1016/0006-291x(87)90729-7;
RA Hay R.E., Woods W.D., Church R.L., Petrash J.M.;
RT "cDNA clones encoding bovine gamma-crystallins.";
RL Biochem. Biophys. Res. Commun. 146:332-338(1987).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
RX PubMed=15299634; DOI=10.1107/s0907444996000352;
RA Chirgadze Y.N., Driessen H.P.C., Wright G., Slingsby C., Hay R.E.,
RA Lindley P.F.;
RT "Structure of bovine eye lens gammaD (gammaIIIb)-crystallin at 1.95 A.";
RL Acta Crystallogr. D 52:712-721(1996).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; L27070; AAA98995.1; -; mRNA.
DR EMBL; M16895; AAB59282.1; -; mRNA.
DR PIR; B29655; B29655.
DR RefSeq; NP_776716.1; NM_174291.2.
DR PDB; 1ELP; X-ray; 1.95 A; A/B=2-174.
DR PDBsum; 1ELP; -.
DR AlphaFoldDB; P08209; -.
DR PCDDB; P08209; -.
DR SMR; P08209; -.
DR STRING; 9913.ENSBTAP00000029019; -.
DR PaxDb; P08209; -.
DR PRIDE; P08209; -.
DR GeneID; 281723; -.
DR KEGG; bta:281723; -.
DR CTD; 1421; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR InParanoid; P08209; -.
DR OrthoDB; 1220704at2759; -.
DR EvolutionaryTrace; P08209; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Eye lens protein;
KW Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin D"
FT /id="PRO_0000057582"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT CONFLICT 76
FT /note="V -> I (in Ref. 2; AAB59282)"
FT /evidence="ECO:0000305"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:1ELP"
FT HELIX 10..12
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 13..21
FT /evidence="ECO:0007829|PDB:1ELP"
FT TURN 27..29
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 34..41
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 43..49
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 53..58
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 60..65
FT /evidence="ECO:0007829|PDB:1ELP"
FT HELIX 66..69
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 78..81
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 89..95
FT /evidence="ECO:0007829|PDB:1ELP"
FT TURN 96..98
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 99..107
FT /evidence="ECO:0007829|PDB:1ELP"
FT HELIX 112..115
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 123..129
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 131..136
FT /evidence="ECO:0007829|PDB:1ELP"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 140..146
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 148..153
FT /evidence="ECO:0007829|PDB:1ELP"
FT HELIX 154..157
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 160..163
FT /evidence="ECO:0007829|PDB:1ELP"
FT STRAND 166..169
FT /evidence="ECO:0007829|PDB:1ELP"
SQ SEQUENCE 174 AA; 20866 MW; 6B13F1A266AA4BBF CRC64;
MGKITFYEDR GFQGRHYECS SDHSNLQPYL GRCNSVRVDS GCWMIYEQPN YLGPQYFLRR
GDYPDYQQWM GLNDSVRSCR LIPHAGSHRL RLYEREDYRG QMIEITEDCS SLQDRFHFNE
IHSLNVLEGS WVLYELPNYR GRQYLLRPGE YRRYHDWGAM NAKVGSLRRV IDIY
