ID   CRGD_MACFL              Reviewed;         174 AA.
AC   Q5EF39;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Gamma-crystallin D;
DE   AltName: Full=Gamma-D-crystallin;
GN   Name=CRYGD;
OS   Macropus fuliginosus (Western gray kangaroo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Macropus.
OX   NCBI_TaxID=9316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=15853812; DOI=10.1111/j.1742-4658.2005.04655.x;
RA   Wistow G., Wyatt K., David L., Gao C., Bateman O., Bernstein S.,
RA   Tomarev S., Segovia L., Slingsby C., Vihtelic T.;
RT   "Gamma-N-crystallin and the evolution of the betagamma-crystallin
RT   superfamily in vertebrates.";
RL   FEBS J. 272:2276-2291(2005).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; AY898645; AAW82717.1; -; mRNA.
DR   AlphaFoldDB; Q5EF39; -.
DR   SMR; Q5EF39; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat; Sensory transduction.
FT   CHAIN           1..174
FT                   /note="Gamma-crystallin D"
FT                   /id="PRO_0000289608"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..128
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          129..171
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..87
FT                   /note="Connecting peptide"
SQ   SEQUENCE   174 AA;  20974 MW;  76F0EDA855436162 CRC64;
     MGKITFYEDR GFQGRCYECS SDHVNLQSYF SRCNSIRVDS GCWMIYERPN YSGYQYYLRR
     GEYPDYQDWM GFNDSIKSCR IIPYSGSHKM RLYEREDYKG QMMELTDDCS CVQDRFHLNE
     IHSLNVLDGC WILYEMPNYR GRQFLLRPGE YRRYLDWGAM NAKVGSLRRV IDVY