CRGD_MOUSE
ID CRGD_MOUSE Reviewed; 174 AA.
AC P04342; O89027; Q6PGI0;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Gamma-crystallin D;
DE AltName: Full=Gamma-D-crystallin;
DE AltName: Full=Gamma-crystallin 1;
GN Name=Crygd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6096855; DOI=10.1073/pnas.81.24.7762;
RA Breitman M.L., Lok S., Wistow G., Piatigorsky J., Treton J.A., Gold R.J.M.,
RA Tsui L.-C.;
RT "Gamma-crystallin family of the mouse lens: structural and evolutionary
RT relationships.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:7762-7766(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-105.
RC STRAIN=102 X C3H;
RX PubMed=9782080; DOI=10.1006/geno.1998.5417;
RA Klopp N., Favor J., Loester J., Lutz R.B., Neuhaeuser-Klaus A.,
RA Prescott A., Pretsch W., Quinlan R.A., Sandilands A., Vrensen G.F.J.M.,
RA Graw J.;
RT "Three murine cataract mutants (Cat2) are defective in different gamma-
RT crystallin genes.";
RL Genomics 52:152-158(1998).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=27517863; DOI=10.1371/journal.pone.0161140;
RA Hartwich H., Rosengauer E., Ruettiger L., Wilms V., Waterholter S.K.,
RA Nothwang H.G.;
RT "Functional Role of gamma-Crystallin N in the Auditory Hindbrain.";
RL PLoS ONE 11:E0161140-E0161140(2016).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- TISSUE SPECIFICITY: Detected in the superior olivary complex of the
CC auditory hindbrain. {ECO:0000269|PubMed:27517863}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC mouse lens.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; K02583; AAA37475.1; -; mRNA.
DR EMBL; AK136286; BAE22915.1; -; mRNA.
DR EMBL; AC158958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057013; AAH57013.1; -; mRNA.
DR EMBL; BC132116; AAI32117.1; -; mRNA.
DR EMBL; BC132118; AAI32119.1; -; mRNA.
DR EMBL; AJ224342; CAA11908.1; -; Genomic_DNA.
DR CCDS; CCDS35599.1; -.
DR PIR; A02932; CYMSG1.
DR RefSeq; NP_031802.2; NM_007776.2.
DR AlphaFoldDB; P04342; -.
DR SMR; P04342; -.
DR STRING; 10090.ENSMUSP00000045327; -.
DR PhosphoSitePlus; P04342; -.
DR PaxDb; P04342; -.
DR PRIDE; P04342; -.
DR ProteomicsDB; 284169; -.
DR DNASU; 12967; -.
DR Ensembl; ENSMUST00000045028; ENSMUSP00000045327; ENSMUSG00000067299.
DR GeneID; 12967; -.
DR KEGG; mmu:12967; -.
DR UCSC; uc007bhg.2; mouse.
DR CTD; 1421; -.
DR MGI; MGI:88524; Crygd.
DR VEuPathDB; HostDB:ENSMUSG00000067299; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000163272; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; P04342; -.
DR OMA; YRGQMME; -.
DR OrthoDB; 1220704at2759; -.
DR PhylomeDB; P04342; -.
DR BioGRID-ORCS; 12967; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Crygd; mouse.
DR PRO; PR:P04342; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P04342; protein.
DR Bgee; ENSMUSG00000067299; Expressed in epithelium of lens and 50 other tissues.
DR ExpressionAtlas; P04342; baseline and differential.
DR Genevisible; P04342; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005212; F:structural constituent of eye lens; IDA:MGI.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; ISO:MGI.
DR GO; GO:0001654; P:eye development; IMP:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
DR GO; GO:0070306; P:lens fiber cell differentiation; IMP:MGI.
DR GO; GO:0007601; P:visual perception; ISO:MGI.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin D"
FT /id="PRO_0000057598"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT CONFLICT 32
FT /note="R -> H (in Ref. 1; AAA37475)"
FT /evidence="ECO:0000305"
FT CONFLICT 52
FT /note="T -> A (in Ref. 1; AAA37475 and 5; CAA11908)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="M -> V (in Ref. 1; AAA37475 and 5; CAA11908)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="R -> K (in Ref. 1; AAA37475)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 174 AA; 21118 MW; 1AFC29C0269B35A1 CRC64;
MGKITFYEDR GFQGRHYECS TDHSNLQPYF SRCNSVRVDS GCWMLYEQPN FTGCQYFLRR
GDYPDYQQWM GFSDSVRSCR LIPHAGSHRI RLYEREEYRG QMIEFTEDCP SLQDRFHFNE
IYSLNVLEGC WVLYDMTNYR GRQYLLRPGE YRRYHDWGAM NARVGSLRRV MDFY
