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CRGD_RAT
ID   CRGD_RAT                Reviewed;         174 AA.
AC   P10067;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Gamma-crystallin D;
DE   AltName: Full=Gamma-D-crystallin;
DE   AltName: Full=Gamma-crystallin 2-2;
GN   Name=Crygd;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3783678; DOI=10.1016/0022-2836(86)90379-7;
RA   den Dunnen J.T., Moormann R.J.M., Lubsen N.H., Schoenmakers J.G.G.;
RT   "Concerted and divergent evolution within the rat gamma-crystallin gene
RT   family.";
RL   J. Mol. Biol. 189:37-46(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2777080; DOI=10.1016/0378-1119(89)90223-0;
RA   den Dunnen J.T., van Neck J.W., Cremers F.P.M., Lubsen N.H.,
RA   Schoenmakers J.G.G.;
RT   "Nucleotide sequence of the rat gamma-crystallin gene region and comparison
RT   with an orthologous human region.";
RL   Gene 78:201-213(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Lens;
RX   PubMed=7849105; DOI=10.1016/0300-9084(94)90115-5;
RA   Ooki K., Amuro N., Shimizu Y., Okazaki T.;
RT   "High level expression of rat gamma-D-crystallin in Escherichia coli.";
RL   Biochimie 76:398-403(1994).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=27517863; DOI=10.1371/journal.pone.0161140;
RA   Hartwich H., Rosengauer E., Ruettiger L., Wilms V., Waterholter S.K.,
RA   Nothwang H.G.;
RT   "Functional Role of gamma-Crystallin N in the Auditory Hindbrain.";
RL   PLoS ONE 11:E0161140-E0161140(2016).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- TISSUE SPECIFICITY: Detected in the superior olivary complex and fibers
CC       of the ventral aoustic stria of the auditory hindbrain.
CC       {ECO:0000269|PubMed:27517863}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC       rat lens.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; M19359; AAA40984.1; -; Genomic_DNA.
DR   EMBL; X57169; CAA40458.1; -; mRNA.
DR   PIR; D24060; D24060.
DR   RefSeq; NP_149086.1; NM_033095.1.
DR   AlphaFoldDB; P10067; -.
DR   SMR; P10067; -.
DR   STRING; 10116.ENSRNOP00000060248; -.
DR   PhosphoSitePlus; P10067; -.
DR   PaxDb; P10067; -.
DR   Ensembl; ENSRNOT00000050886; ENSRNOP00000051301; ENSRNOG00000032219.
DR   GeneID; 24278; -.
DR   KEGG; rno:24278; -.
DR   UCSC; RGD:2422; rat.
DR   CTD; 1421; -.
DR   RGD; 2422; Crygd.
DR   eggNOG; ENOG502RXJY; Eukaryota.
DR   GeneTree; ENSGT00940000163272; -.
DR   HOGENOM; CLU_081883_1_1_1; -.
DR   InParanoid; P10067; -.
DR   OMA; YRGQMME; -.
DR   OrthoDB; 1220704at2759; -.
DR   PhylomeDB; P10067; -.
DR   PRO; PR:P10067; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000032219; Expressed in Ammon's horn and 3 other tissues.
DR   ExpressionAtlas; P10067; baseline and differential.
DR   Genevisible; P10067; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005212; F:structural constituent of eye lens; IMP:RGD.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; ISO:RGD.
DR   GO; GO:0001654; P:eye development; ISO:RGD.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEP:RGD.
DR   GO; GO:0070306; P:lens fiber cell differentiation; IDA:RGD.
DR   GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR   GO; GO:0007601; P:visual perception; ISO:RGD.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..174
FT                   /note="Gamma-crystallin D"
FT                   /id="PRO_0000057592"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..128
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          129..171
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..87
FT                   /note="Connecting peptide"
SQ   SEQUENCE   174 AA;  21104 MW;  21C08F0B859A71F7 CRC64;
     MGKITFYEDR GFQGRHYECS TDHSNLQPYF SRCNSVRVDS GCWMLYEQPN FTGCQYFLRR
     GDYPDYQQWM GFSDSVRSCR LIPHAGSHRI RLYEREDYRG QMVEFTEDCP SLQDRFHFNE
     IYSLNVLEGC WVLYEMTNYR GRQYLLRPGE YRRYHDWGAM NARVGSLRRV MDFY
 
 
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