CRGD_RAT
ID CRGD_RAT Reviewed; 174 AA.
AC P10067;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Gamma-crystallin D;
DE AltName: Full=Gamma-D-crystallin;
DE AltName: Full=Gamma-crystallin 2-2;
GN Name=Crygd;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=3783678; DOI=10.1016/0022-2836(86)90379-7;
RA den Dunnen J.T., Moormann R.J.M., Lubsen N.H., Schoenmakers J.G.G.;
RT "Concerted and divergent evolution within the rat gamma-crystallin gene
RT family.";
RL J. Mol. Biol. 189:37-46(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2777080; DOI=10.1016/0378-1119(89)90223-0;
RA den Dunnen J.T., van Neck J.W., Cremers F.P.M., Lubsen N.H.,
RA Schoenmakers J.G.G.;
RT "Nucleotide sequence of the rat gamma-crystallin gene region and comparison
RT with an orthologous human region.";
RL Gene 78:201-213(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Lens;
RX PubMed=7849105; DOI=10.1016/0300-9084(94)90115-5;
RA Ooki K., Amuro N., Shimizu Y., Okazaki T.;
RT "High level expression of rat gamma-D-crystallin in Escherichia coli.";
RL Biochimie 76:398-403(1994).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=27517863; DOI=10.1371/journal.pone.0161140;
RA Hartwich H., Rosengauer E., Ruettiger L., Wilms V., Waterholter S.K.,
RA Nothwang H.G.;
RT "Functional Role of gamma-Crystallin N in the Auditory Hindbrain.";
RL PLoS ONE 11:E0161140-E0161140(2016).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- TISSUE SPECIFICITY: Detected in the superior olivary complex and fibers
CC of the ventral aoustic stria of the auditory hindbrain.
CC {ECO:0000269|PubMed:27517863}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC rat lens.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; M19359; AAA40984.1; -; Genomic_DNA.
DR EMBL; X57169; CAA40458.1; -; mRNA.
DR PIR; D24060; D24060.
DR RefSeq; NP_149086.1; NM_033095.1.
DR AlphaFoldDB; P10067; -.
DR SMR; P10067; -.
DR STRING; 10116.ENSRNOP00000060248; -.
DR PhosphoSitePlus; P10067; -.
DR PaxDb; P10067; -.
DR Ensembl; ENSRNOT00000050886; ENSRNOP00000051301; ENSRNOG00000032219.
DR GeneID; 24278; -.
DR KEGG; rno:24278; -.
DR UCSC; RGD:2422; rat.
DR CTD; 1421; -.
DR RGD; 2422; Crygd.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000163272; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; P10067; -.
DR OMA; YRGQMME; -.
DR OrthoDB; 1220704at2759; -.
DR PhylomeDB; P10067; -.
DR PRO; PR:P10067; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000032219; Expressed in Ammon's horn and 3 other tissues.
DR ExpressionAtlas; P10067; baseline and differential.
DR Genevisible; P10067; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005212; F:structural constituent of eye lens; IMP:RGD.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; ISO:RGD.
DR GO; GO:0001654; P:eye development; ISO:RGD.
DR GO; GO:0002088; P:lens development in camera-type eye; IEP:RGD.
DR GO; GO:0070306; P:lens fiber cell differentiation; IDA:RGD.
DR GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR GO; GO:0007601; P:visual perception; ISO:RGD.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin D"
FT /id="PRO_0000057592"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
SQ SEQUENCE 174 AA; 21104 MW; 21C08F0B859A71F7 CRC64;
MGKITFYEDR GFQGRHYECS TDHSNLQPYF SRCNSVRVDS GCWMLYEQPN FTGCQYFLRR
GDYPDYQQWM GFSDSVRSCR LIPHAGSHRI RLYEREDYRG QMVEFTEDCP SLQDRFHFNE
IYSLNVLEGC WVLYEMTNYR GRQYLLRPGE YRRYHDWGAM NARVGSLRRV MDFY